Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice
Dietary fish intake has proven to have health benefits in humans. n-3 polyunsaturated fatty acids (PUFAs) in fish oil (FO), especially, may provide protection against age-related cognitive disorders. Owing to the unique benefits of n-3 PUFAs, other nutrients, such as fish protein (FP), have not been...
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ftpubmed:oai:pubmedcentral.nih.gov:9658838 2023-05-15T13:09:24+02:00 Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice Murakami, Yuki Hosomi, Ryota Nishimoto, Ayano Nishiyama, Toshimasa Yoshida, Munehiro Fukunaga, Kenji 2022-11-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658838/ http://www.ncbi.nlm.nih.gov/pubmed/36364879 https://doi.org/10.3390/nu14214618 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658838/ http://www.ncbi.nlm.nih.gov/pubmed/36364879 http://dx.doi.org/10.3390/nu14214618 © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY Nutrients Article Text 2022 ftpubmed https://doi.org/10.3390/nu14214618 2022-11-20T02:42:05Z Dietary fish intake has proven to have health benefits in humans. n-3 polyunsaturated fatty acids (PUFAs) in fish oil (FO), especially, may provide protection against age-related cognitive disorders. Owing to the unique benefits of n-3 PUFAs, other nutrients, such as fish protein (FP), have not been well studied. To clarify the effects of FO and FP on brain function, we investigated whether FO or FP feeding can prevent age-related cognitive dysfunction in senescence-accelerated mouse-prone 10 (SAMP10) mice. The FP group maintained a better working memory compared to the control and FO groups in the Y-maze test, but not episodic memory in the novel object recognition test. To evaluate demyelination levels, we measured neurofilament H (NfH) and myelin basic protein (MBP) immunoreactivity in the hippocampus (Hipp). Axon morphology was maintained in the FP group, but not in the control and FO groups. Additionally, the percentage of positive area for double-staining with NfH/MPB was significantly higher in the Hipp of FP-fed mice than in the control (p < 0.05). These results suggest that FP intake prevents age-related cognitive dysfunction by maintaining axonal morphology in the Hipp of SAMP10 mice. Text alaska pollock Alaska PubMed Central (PMC) The ''Y'' ENVELOPE(-112.453,-112.453,57.591,57.591) Nutrients 14 21 4618 |
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Article Murakami, Yuki Hosomi, Ryota Nishimoto, Ayano Nishiyama, Toshimasa Yoshida, Munehiro Fukunaga, Kenji Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice |
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description |
Dietary fish intake has proven to have health benefits in humans. n-3 polyunsaturated fatty acids (PUFAs) in fish oil (FO), especially, may provide protection against age-related cognitive disorders. Owing to the unique benefits of n-3 PUFAs, other nutrients, such as fish protein (FP), have not been well studied. To clarify the effects of FO and FP on brain function, we investigated whether FO or FP feeding can prevent age-related cognitive dysfunction in senescence-accelerated mouse-prone 10 (SAMP10) mice. The FP group maintained a better working memory compared to the control and FO groups in the Y-maze test, but not episodic memory in the novel object recognition test. To evaluate demyelination levels, we measured neurofilament H (NfH) and myelin basic protein (MBP) immunoreactivity in the hippocampus (Hipp). Axon morphology was maintained in the FP group, but not in the control and FO groups. Additionally, the percentage of positive area for double-staining with NfH/MPB was significantly higher in the Hipp of FP-fed mice than in the control (p < 0.05). These results suggest that FP intake prevents age-related cognitive dysfunction by maintaining axonal morphology in the Hipp of SAMP10 mice. |
format |
Text |
author |
Murakami, Yuki Hosomi, Ryota Nishimoto, Ayano Nishiyama, Toshimasa Yoshida, Munehiro Fukunaga, Kenji |
author_facet |
Murakami, Yuki Hosomi, Ryota Nishimoto, Ayano Nishiyama, Toshimasa Yoshida, Munehiro Fukunaga, Kenji |
author_sort |
Murakami, Yuki |
title |
Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice |
title_short |
Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice |
title_full |
Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice |
title_fullStr |
Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice |
title_full_unstemmed |
Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice |
title_sort |
protective effects of fish (alaska pollock) protein intake against short-term memory decline in senescence-accelerated mice |
publisher |
MDPI |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658838/ http://www.ncbi.nlm.nih.gov/pubmed/36364879 https://doi.org/10.3390/nu14214618 |
long_lat |
ENVELOPE(-112.453,-112.453,57.591,57.591) |
geographic |
The ''Y'' |
geographic_facet |
The ''Y'' |
genre |
alaska pollock Alaska |
genre_facet |
alaska pollock Alaska |
op_source |
Nutrients |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658838/ http://www.ncbi.nlm.nih.gov/pubmed/36364879 http://dx.doi.org/10.3390/nu14214618 |
op_rights |
© 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/nu14214618 |
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Nutrients |
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14 |
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21 |
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