HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2
The aggressive infectious nature of SARS-CoV-2, its rapid spread, and the emergence of mutations necessitate investigation of factors contributing to differences in SARS-CoV-2 susceptibility and severity. The role of genetic variations in the human HLA continues to be studied in various populations...
Published in: | International Journal of Environmental Research and Public Health |
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657774/ http://www.ncbi.nlm.nih.gov/pubmed/36360904 https://doi.org/10.3390/ijerph192114024 |
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ftpubmed:oai:pubmedcentral.nih.gov:9657774 2023-05-15T17:46:04+02:00 HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2 Bubnova, Ludmila Pavlova, Irina Terentieva, Maria Glazanova, Tatiana Belyaeva, Elena Sidorkevich, Sergei Bashketova, Nataliya Chkhingeria, Irina Kozhemyakina, Mal’vina Azarov, Daniil Kuznetsova, Raisa Ramsay, Edward S. Gladkikh, Anna Sharova, Alena Dedkov, Vladimir Totolian, Areg 2022-10-28 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657774/ http://www.ncbi.nlm.nih.gov/pubmed/36360904 https://doi.org/10.3390/ijerph192114024 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657774/ http://www.ncbi.nlm.nih.gov/pubmed/36360904 http://dx.doi.org/10.3390/ijerph192114024 © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY Int J Environ Res Public Health Article Text 2022 ftpubmed https://doi.org/10.3390/ijerph192114024 2022-11-20T02:38:29Z The aggressive infectious nature of SARS-CoV-2, its rapid spread, and the emergence of mutations necessitate investigation of factors contributing to differences in SARS-CoV-2 susceptibility and severity. The role of genetic variations in the human HLA continues to be studied in various populations in terms of both its effect on morbidity and clinical manifestation of illness. The study included 484 COVID-19 convalescents (northwest Russia residents of St. Petersburg). Cases in which the responsible strain was determined were divided in two subgroups: group 1 (n = 231) had illness caused by genovariants unrelated to variant of concern (VOC) strains; and group 2 (n = 80) had illness caused by the delta (B.1.617.2) VOC; and a control group (n = 1456). DNA typing (HLA-A, B, DRB1) was performed at the basic resolution level. HLA-A*02 was associated with protection against infection caused by non-VOC SARS-CoV-2 genetic variants only but not against infection caused by delta strains. HLA-A*03 was associated with protection against infection caused by delta strains; and allele groups associated with infection by delta strains were HLA-A*30, B*49, and B*57. Thus, in northwest Russia, HLA-A*02 was associated with protection against infection caused by non-VOC SARS-CoV-2 genetic variants but not against delta viral strains. HLA-A*03 was associated with a reduced risk of infection by delta SARS-CoV-2 strains. HLA-A*30, HLA-B*49, and HLA-B*57 allele groups were predisposing factors for infection by delta (B.1.617.2) strains. Text Northwest Russia PubMed Central (PMC) International Journal of Environmental Research and Public Health 19 21 14024 |
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Article Bubnova, Ludmila Pavlova, Irina Terentieva, Maria Glazanova, Tatiana Belyaeva, Elena Sidorkevich, Sergei Bashketova, Nataliya Chkhingeria, Irina Kozhemyakina, Mal’vina Azarov, Daniil Kuznetsova, Raisa Ramsay, Edward S. Gladkikh, Anna Sharova, Alena Dedkov, Vladimir Totolian, Areg HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2 |
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description |
The aggressive infectious nature of SARS-CoV-2, its rapid spread, and the emergence of mutations necessitate investigation of factors contributing to differences in SARS-CoV-2 susceptibility and severity. The role of genetic variations in the human HLA continues to be studied in various populations in terms of both its effect on morbidity and clinical manifestation of illness. The study included 484 COVID-19 convalescents (northwest Russia residents of St. Petersburg). Cases in which the responsible strain was determined were divided in two subgroups: group 1 (n = 231) had illness caused by genovariants unrelated to variant of concern (VOC) strains; and group 2 (n = 80) had illness caused by the delta (B.1.617.2) VOC; and a control group (n = 1456). DNA typing (HLA-A, B, DRB1) was performed at the basic resolution level. HLA-A*02 was associated with protection against infection caused by non-VOC SARS-CoV-2 genetic variants only but not against infection caused by delta strains. HLA-A*03 was associated with protection against infection caused by delta strains; and allele groups associated with infection by delta strains were HLA-A*30, B*49, and B*57. Thus, in northwest Russia, HLA-A*02 was associated with protection against infection caused by non-VOC SARS-CoV-2 genetic variants but not against delta viral strains. HLA-A*03 was associated with a reduced risk of infection by delta SARS-CoV-2 strains. HLA-A*30, HLA-B*49, and HLA-B*57 allele groups were predisposing factors for infection by delta (B.1.617.2) strains. |
format |
Text |
author |
Bubnova, Ludmila Pavlova, Irina Terentieva, Maria Glazanova, Tatiana Belyaeva, Elena Sidorkevich, Sergei Bashketova, Nataliya Chkhingeria, Irina Kozhemyakina, Mal’vina Azarov, Daniil Kuznetsova, Raisa Ramsay, Edward S. Gladkikh, Anna Sharova, Alena Dedkov, Vladimir Totolian, Areg |
author_facet |
Bubnova, Ludmila Pavlova, Irina Terentieva, Maria Glazanova, Tatiana Belyaeva, Elena Sidorkevich, Sergei Bashketova, Nataliya Chkhingeria, Irina Kozhemyakina, Mal’vina Azarov, Daniil Kuznetsova, Raisa Ramsay, Edward S. Gladkikh, Anna Sharova, Alena Dedkov, Vladimir Totolian, Areg |
author_sort |
Bubnova, Ludmila |
title |
HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2 |
title_short |
HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2 |
title_full |
HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2 |
title_fullStr |
HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2 |
title_full_unstemmed |
HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2 |
title_sort |
hla genotypes in patients with infection caused by different strains of sars-cov-2 |
publisher |
MDPI |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657774/ http://www.ncbi.nlm.nih.gov/pubmed/36360904 https://doi.org/10.3390/ijerph192114024 |
genre |
Northwest Russia |
genre_facet |
Northwest Russia |
op_source |
Int J Environ Res Public Health |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657774/ http://www.ncbi.nlm.nih.gov/pubmed/36360904 http://dx.doi.org/10.3390/ijerph192114024 |
op_rights |
© 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/ijerph192114024 |
container_title |
International Journal of Environmental Research and Public Health |
container_volume |
19 |
container_issue |
21 |
container_start_page |
14024 |
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1766149409653915648 |