Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results
BACKGROUND AND PURPOSE: Breast intra operative radiation therapy has been evaluated with different systems delivering 20–21 Gy with treatment times around 30 min. Papillon + (TM) Contact X-ray machine was designed to produce a 50 kVp beam with a high dose rate ≥ 15 Gy/minute. A pilot study with the...
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ftpubmed:oai:pubmedcentral.nih.gov:9638720 2023-05-15T18:22:49+02:00 Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results Chand-Fouché, Marie-Eve Colnard, Claudine Gal, Jocelyn Lam Cham Kee, Daniel Dejean, Catherine Gautier, Matthieu Feuillade, Julien Mana, Aurélia Fouché, Yves Delpech, Yann Dejode, Magali Gérard, Jean-Pierre Barranger, Emmanuel 2022-10-21 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638720/ http://www.ncbi.nlm.nih.gov/pubmed/36353651 https://doi.org/10.1016/j.ctro.2022.10.006 en eng Elsevier http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638720/ http://www.ncbi.nlm.nih.gov/pubmed/36353651 http://dx.doi.org/10.1016/j.ctro.2022.10.006 © 2022 Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). CC-BY-NC-ND Clin Transl Radiat Oncol Article Text 2022 ftpubmed https://doi.org/10.1016/j.ctro.2022.10.006 2022-11-13T01:38:58Z BACKGROUND AND PURPOSE: Breast intra operative radiation therapy has been evaluated with different systems delivering 20–21 Gy with treatment times around 30 min. Papillon + (TM) Contact X-ray machine was designed to produce a 50 kVp beam with a high dose rate ≥ 15 Gy/minute. A pilot study with the first prototype was conducted in Nice. MATERIALS AND METHODS: The inclusion criteria were age ≥ 60 years, unifocal ductal breast adenocarcinoma ≤ 2.5 cm, grade 1–2. Surgical local excision with sentinel node dissection was performed and the applicator was placed in the tumor bed after excision with a prescribed dose of 20 Gy. The main end point of the study was the doses measured with the Gafchromic films; two were located at the skin surface and two in the excision cavity. Secondary endpoints were early toxicity and relapse free survival. RESULTS: Between 10/2018 and 09/2019, 26 patients were included. Mean Gafchromic doses were 18.8 Gy ± 2 Gy at the south pole, 15.6 Gy ± 2.81 Gy at the equator and 2.5 Gy ± 1.67 Gy at the skin. With a median follow-up time of 12 months, no skin or subcutaneous toxicity > grade 2, no local relapse and no metastasis were observed. CONCLUSION: This is the first phase II study testing the Papillon + (tm) system for breast IORT with in vivo dosimetry measurements and reassuring clinical data. Text South pole PubMed Central (PMC) South Pole Clinical and Translational Radiation Oncology 38 47 52 |
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Article Chand-Fouché, Marie-Eve Colnard, Claudine Gal, Jocelyn Lam Cham Kee, Daniel Dejean, Catherine Gautier, Matthieu Feuillade, Julien Mana, Aurélia Fouché, Yves Delpech, Yann Dejode, Magali Gérard, Jean-Pierre Barranger, Emmanuel Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results |
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BACKGROUND AND PURPOSE: Breast intra operative radiation therapy has been evaluated with different systems delivering 20–21 Gy with treatment times around 30 min. Papillon + (TM) Contact X-ray machine was designed to produce a 50 kVp beam with a high dose rate ≥ 15 Gy/minute. A pilot study with the first prototype was conducted in Nice. MATERIALS AND METHODS: The inclusion criteria were age ≥ 60 years, unifocal ductal breast adenocarcinoma ≤ 2.5 cm, grade 1–2. Surgical local excision with sentinel node dissection was performed and the applicator was placed in the tumor bed after excision with a prescribed dose of 20 Gy. The main end point of the study was the doses measured with the Gafchromic films; two were located at the skin surface and two in the excision cavity. Secondary endpoints were early toxicity and relapse free survival. RESULTS: Between 10/2018 and 09/2019, 26 patients were included. Mean Gafchromic doses were 18.8 Gy ± 2 Gy at the south pole, 15.6 Gy ± 2.81 Gy at the equator and 2.5 Gy ± 1.67 Gy at the skin. With a median follow-up time of 12 months, no skin or subcutaneous toxicity > grade 2, no local relapse and no metastasis were observed. CONCLUSION: This is the first phase II study testing the Papillon + (tm) system for breast IORT with in vivo dosimetry measurements and reassuring clinical data. |
format |
Text |
author |
Chand-Fouché, Marie-Eve Colnard, Claudine Gal, Jocelyn Lam Cham Kee, Daniel Dejean, Catherine Gautier, Matthieu Feuillade, Julien Mana, Aurélia Fouché, Yves Delpech, Yann Dejode, Magali Gérard, Jean-Pierre Barranger, Emmanuel |
author_facet |
Chand-Fouché, Marie-Eve Colnard, Claudine Gal, Jocelyn Lam Cham Kee, Daniel Dejean, Catherine Gautier, Matthieu Feuillade, Julien Mana, Aurélia Fouché, Yves Delpech, Yann Dejode, Magali Gérard, Jean-Pierre Barranger, Emmanuel |
author_sort |
Chand-Fouché, Marie-Eve |
title |
Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results |
title_short |
Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results |
title_full |
Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results |
title_fullStr |
Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results |
title_full_unstemmed |
Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results |
title_sort |
feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: first results |
publisher |
Elsevier |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638720/ http://www.ncbi.nlm.nih.gov/pubmed/36353651 https://doi.org/10.1016/j.ctro.2022.10.006 |
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South Pole |
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South pole |
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South pole |
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Clin Transl Radiat Oncol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638720/ http://www.ncbi.nlm.nih.gov/pubmed/36353651 http://dx.doi.org/10.1016/j.ctro.2022.10.006 |
op_rights |
© 2022 Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.ctro.2022.10.006 |
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Clinical and Translational Radiation Oncology |
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38 |
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47 |
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52 |
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1766202227702104064 |