Hand grip strength and risk of incident venous thromboembolism: The Tromsø study
BACKGROUND: Hand grip strength (HGS), a common proxy of whole‐body muscular strength, is associated with a wide range of adverse health outcomes and mortality. However, there are limited data on the association between HGS and risk of venous thromboembolism (VTE). OBJECTIVES: We aimed to investigate...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634490/ http://www.ncbi.nlm.nih.gov/pubmed/36349264 https://doi.org/10.1002/rth2.12833 |
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ftpubmed:oai:pubmedcentral.nih.gov:9634490 2023-05-15T18:34:28+02:00 Hand grip strength and risk of incident venous thromboembolism: The Tromsø study Leknessund, Oda G. R. Morelli, Vania M. Strand, Bjørn Heine Hansen, John‐Bjarne Brækkan, Sigrid K. 2022-11-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634490/ http://www.ncbi.nlm.nih.gov/pubmed/36349264 https://doi.org/10.1002/rth2.12833 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634490/ http://www.ncbi.nlm.nih.gov/pubmed/36349264 http://dx.doi.org/10.1002/rth2.12833 © 2022 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis (ISTH). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. CC-BY-NC-ND Res Pract Thromb Haemost Original Articles Text 2022 ftpubmed https://doi.org/10.1002/rth2.12833 2022-11-13T01:31:24Z BACKGROUND: Hand grip strength (HGS), a common proxy of whole‐body muscular strength, is associated with a wide range of adverse health outcomes and mortality. However, there are limited data on the association between HGS and risk of venous thromboembolism (VTE). OBJECTIVES: We aimed to investigate the association between HGS and risk of incident VTE in a population‐based cohort. METHODS: Participants (n = 13,704) from the fourth to seventh surveys of the Tromsø study (Tromsø4–Tromsø7, enrollment: 1994–2016) were followed throughout 2020, and all incident VTEs were recorded. HGS of the nondominant hand was measured using a Martin Vigorimeter (Tromsø4–Tromsø6) and a Jamar Digital Dynamometer (Tromsø7). Hazard ratios (HRs) for VTE with 95% confidence intervals (CIs) according to weak HGS (less than 25th percentile) versus normal HGS (25th percentile or greater) were estimated using Cox regression models and adjusted for age, sex, body height, body mass index, physical activity, cardiovascular disease, and cancer. RESULTS: During a median of 6.5 years of follow‐up, 545 incident VTEs occurred. Participants with weak HGS had a 27% higher risk of VTE (HR, 1.27; 95% CI, 1.03–1.57) compared to those with normal HGS. Subgroup analyses revealed that the point estimates were higher for unprovoked VTE (HR, 1.35; 95% CI, 0.96–1.91) and deep vein thrombosis (DVT; HR, 1.52; 95% CI, 1.14–2.01). Similar results were found in analyses restricted to men, women, and elderly (aged greater than 75 years). CONCLUSION: A weak HGS was associated with increased risk of VTE, and particularly unprovoked VTE and isolated DVT. Our findings suggest that weak muscle strength may be a risk factor for VTE. Text Tromsø PubMed Central (PMC) Tromsø Research and Practice in Thrombosis and Haemostasis 6 7 e12833 |
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Original Articles Leknessund, Oda G. R. Morelli, Vania M. Strand, Bjørn Heine Hansen, John‐Bjarne Brækkan, Sigrid K. Hand grip strength and risk of incident venous thromboembolism: The Tromsø study |
topic_facet |
Original Articles |
description |
BACKGROUND: Hand grip strength (HGS), a common proxy of whole‐body muscular strength, is associated with a wide range of adverse health outcomes and mortality. However, there are limited data on the association between HGS and risk of venous thromboembolism (VTE). OBJECTIVES: We aimed to investigate the association between HGS and risk of incident VTE in a population‐based cohort. METHODS: Participants (n = 13,704) from the fourth to seventh surveys of the Tromsø study (Tromsø4–Tromsø7, enrollment: 1994–2016) were followed throughout 2020, and all incident VTEs were recorded. HGS of the nondominant hand was measured using a Martin Vigorimeter (Tromsø4–Tromsø6) and a Jamar Digital Dynamometer (Tromsø7). Hazard ratios (HRs) for VTE with 95% confidence intervals (CIs) according to weak HGS (less than 25th percentile) versus normal HGS (25th percentile or greater) were estimated using Cox regression models and adjusted for age, sex, body height, body mass index, physical activity, cardiovascular disease, and cancer. RESULTS: During a median of 6.5 years of follow‐up, 545 incident VTEs occurred. Participants with weak HGS had a 27% higher risk of VTE (HR, 1.27; 95% CI, 1.03–1.57) compared to those with normal HGS. Subgroup analyses revealed that the point estimates were higher for unprovoked VTE (HR, 1.35; 95% CI, 0.96–1.91) and deep vein thrombosis (DVT; HR, 1.52; 95% CI, 1.14–2.01). Similar results were found in analyses restricted to men, women, and elderly (aged greater than 75 years). CONCLUSION: A weak HGS was associated with increased risk of VTE, and particularly unprovoked VTE and isolated DVT. Our findings suggest that weak muscle strength may be a risk factor for VTE. |
format |
Text |
author |
Leknessund, Oda G. R. Morelli, Vania M. Strand, Bjørn Heine Hansen, John‐Bjarne Brækkan, Sigrid K. |
author_facet |
Leknessund, Oda G. R. Morelli, Vania M. Strand, Bjørn Heine Hansen, John‐Bjarne Brækkan, Sigrid K. |
author_sort |
Leknessund, Oda G. R. |
title |
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study |
title_short |
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study |
title_full |
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study |
title_fullStr |
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study |
title_full_unstemmed |
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study |
title_sort |
hand grip strength and risk of incident venous thromboembolism: the tromsø study |
publisher |
John Wiley and Sons Inc. |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634490/ http://www.ncbi.nlm.nih.gov/pubmed/36349264 https://doi.org/10.1002/rth2.12833 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Res Pract Thromb Haemost |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634490/ http://www.ncbi.nlm.nih.gov/pubmed/36349264 http://dx.doi.org/10.1002/rth2.12833 |
op_rights |
© 2022 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis (ISTH). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1002/rth2.12833 |
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Research and Practice in Thrombosis and Haemostasis |
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6 |
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7 |
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e12833 |
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