Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating
[Image: see text] This work presents a novel route for creating metal-free antiviral coatings based on polymer brushes synthesized by surface-initiated photoinduced electron transfer-reversible addition–fragmentation chain transfer (SI-PET-RAFT) polymerization, applying eosin Y as a photocatalyst, w...
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ftpubmed:oai:pubmedcentral.nih.gov:9631418 2023-05-15T15:34:27+02:00 Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating Kuzmyn, Andriy R. Teunissen, Lucas W. Kroese, Michiel V. Kant, Jet Venema, Sandra Zuilhof, Han 2022-10-20 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631418/ https://doi.org/10.1021/acsomega.2c03214 en eng American Chemical Society http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631418/ http://dx.doi.org/10.1021/acsomega.2c03214 © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). CC-BY-NC-ND CC-BY-NC ACS Omega Text 2022 ftpubmed https://doi.org/10.1021/acsomega.2c03214 2022-11-06T02:14:50Z [Image: see text] This work presents a novel route for creating metal-free antiviral coatings based on polymer brushes synthesized by surface-initiated photoinduced electron transfer-reversible addition–fragmentation chain transfer (SI-PET-RAFT) polymerization, applying eosin Y as a photocatalyst, water as a solvent, and visible light as a driving force. The polymer brushes were synthesized using N-[3-(decyldimethyl)-aminopropyl] methacrylamide bromide and carboxybetaine methacrylamide monomers. The chemical composition, thickness, roughness, and wettability of the resulting polymer brush coatings were characterized by X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), water contact angle measurements, and ellipsometry. The antiviral properties of coatings were investigated by exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and avian influenza viruses, with further measurement of residual viable viral particles. The best performance was obtained with Cu surfaces, with a ca. 20-fold reduction of SARS-Cov-2 and a 50-fold reduction in avian influenza. On the polymer brush-modified surfaces, the number of viable virus particles decreased by about 5–6 times faster for avian flu and about 2–3 times faster for SARS-CoV-2, all compared to unmodified silicon surfaces. Interestingly, no significant differences were obtained between quaternary ammonium brushes and zwitterionic brushes. Text Avian flu PubMed Central (PMC) ACS Omega 7 43 38371 38379 |
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[Image: see text] This work presents a novel route for creating metal-free antiviral coatings based on polymer brushes synthesized by surface-initiated photoinduced electron transfer-reversible addition–fragmentation chain transfer (SI-PET-RAFT) polymerization, applying eosin Y as a photocatalyst, water as a solvent, and visible light as a driving force. The polymer brushes were synthesized using N-[3-(decyldimethyl)-aminopropyl] methacrylamide bromide and carboxybetaine methacrylamide monomers. The chemical composition, thickness, roughness, and wettability of the resulting polymer brush coatings were characterized by X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), water contact angle measurements, and ellipsometry. The antiviral properties of coatings were investigated by exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and avian influenza viruses, with further measurement of residual viable viral particles. The best performance was obtained with Cu surfaces, with a ca. 20-fold reduction of SARS-Cov-2 and a 50-fold reduction in avian influenza. On the polymer brush-modified surfaces, the number of viable virus particles decreased by about 5–6 times faster for avian flu and about 2–3 times faster for SARS-CoV-2, all compared to unmodified silicon surfaces. Interestingly, no significant differences were obtained between quaternary ammonium brushes and zwitterionic brushes. |
format |
Text |
author |
Kuzmyn, Andriy R. Teunissen, Lucas W. Kroese, Michiel V. Kant, Jet Venema, Sandra Zuilhof, Han |
spellingShingle |
Kuzmyn, Andriy R. Teunissen, Lucas W. Kroese, Michiel V. Kant, Jet Venema, Sandra Zuilhof, Han Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating |
author_facet |
Kuzmyn, Andriy R. Teunissen, Lucas W. Kroese, Michiel V. Kant, Jet Venema, Sandra Zuilhof, Han |
author_sort |
Kuzmyn, Andriy R. |
title |
Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating |
title_short |
Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating |
title_full |
Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating |
title_fullStr |
Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating |
title_full_unstemmed |
Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating |
title_sort |
antiviral polymer brushes by visible-light-induced, oxygen-tolerant covalent surface coating |
publisher |
American Chemical Society |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631418/ https://doi.org/10.1021/acsomega.2c03214 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_source |
ACS Omega |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631418/ http://dx.doi.org/10.1021/acsomega.2c03214 |
op_rights |
© 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
op_rightsnorm |
CC-BY-NC-ND CC-BY-NC |
op_doi |
https://doi.org/10.1021/acsomega.2c03214 |
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ACS Omega |
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7 |
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43 |
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38371 |
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38379 |
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1766364845775519744 |