Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults
Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015–2020); Swiss HBM4EU study (2020); DIET-HBM Icela...
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ftpubmed:oai:pubmedcentral.nih.gov:9612135 2023-05-15T16:51:02+02:00 Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults Buekers, Jurgen Remy, Sylvie Bessems, Jos Govarts, Eva Rambaud, Loïc Riou, Margaux Halldorsson, Thorhallur I Ólafsdóttir, Kristin Probst-Hensch, Nicole Ammann, Priska Weber, Till Kolossa-Gehring, Marike Esteban-López, Marta Castaño, Argelia Andersen, Helle Raun Schoeters, Greet 2022-09-21 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612135/ http://www.ncbi.nlm.nih.gov/pubmed/36287833 https://doi.org/10.3390/toxics10100552 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612135/ http://www.ncbi.nlm.nih.gov/pubmed/36287833 http://dx.doi.org/10.3390/toxics10100552 © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY Toxics Article Text 2022 ftpubmed https://doi.org/10.3390/toxics10100552 2022-10-30T01:31:29Z Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015–2020); Swiss HBM4EU study (2020); DIET-HBM Iceland (2019–2020); ESTEBAN France (2014–2016)) were included representing Northern and Western Europe. Overall, median values were below the reported quantification limits (LOQs) (0.05–0.1 µg/L). The 95th percentiles (P95) ranged between 0.24 and 0.37 µg/L urine for Gly and between 0.21 and 0.38 µg/L for AMPA. Lower values were observed in adults compared to children. Indications exist for autonomous sources of AMPA in the environment. As for children, reversed dosimetry calculations based on HBM data in adults did not lead to exceedances of the ADI (proposed acceptable daily intake of EFSA for Gly 0.1 mg/kg bw/day based on histopathological findings in the salivary gland of rats) indicating no human health risks in the studied populations at the moment. However, the controversy on carcinogenicity, potential endocrine effects and the absence of a group ADI for Gly and AMPA induce uncertainty to the risk assessment. Exposure determinant analysis showed few significant associations. More data on specific subgroups, such as those occupationally exposed or living close to agricultural fields or with certain consumption patterns (vegetarian, vegan, organic food, high cereal consumer), are needed to evaluate major exposure sources. Text Iceland PubMed Central (PMC) Toxics 10 10 552 |
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Article Buekers, Jurgen Remy, Sylvie Bessems, Jos Govarts, Eva Rambaud, Loïc Riou, Margaux Halldorsson, Thorhallur I Ólafsdóttir, Kristin Probst-Hensch, Nicole Ammann, Priska Weber, Till Kolossa-Gehring, Marike Esteban-López, Marta Castaño, Argelia Andersen, Helle Raun Schoeters, Greet Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults |
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description |
Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015–2020); Swiss HBM4EU study (2020); DIET-HBM Iceland (2019–2020); ESTEBAN France (2014–2016)) were included representing Northern and Western Europe. Overall, median values were below the reported quantification limits (LOQs) (0.05–0.1 µg/L). The 95th percentiles (P95) ranged between 0.24 and 0.37 µg/L urine for Gly and between 0.21 and 0.38 µg/L for AMPA. Lower values were observed in adults compared to children. Indications exist for autonomous sources of AMPA in the environment. As for children, reversed dosimetry calculations based on HBM data in adults did not lead to exceedances of the ADI (proposed acceptable daily intake of EFSA for Gly 0.1 mg/kg bw/day based on histopathological findings in the salivary gland of rats) indicating no human health risks in the studied populations at the moment. However, the controversy on carcinogenicity, potential endocrine effects and the absence of a group ADI for Gly and AMPA induce uncertainty to the risk assessment. Exposure determinant analysis showed few significant associations. More data on specific subgroups, such as those occupationally exposed or living close to agricultural fields or with certain consumption patterns (vegetarian, vegan, organic food, high cereal consumer), are needed to evaluate major exposure sources. |
format |
Text |
author |
Buekers, Jurgen Remy, Sylvie Bessems, Jos Govarts, Eva Rambaud, Loïc Riou, Margaux Halldorsson, Thorhallur I Ólafsdóttir, Kristin Probst-Hensch, Nicole Ammann, Priska Weber, Till Kolossa-Gehring, Marike Esteban-López, Marta Castaño, Argelia Andersen, Helle Raun Schoeters, Greet |
author_facet |
Buekers, Jurgen Remy, Sylvie Bessems, Jos Govarts, Eva Rambaud, Loïc Riou, Margaux Halldorsson, Thorhallur I Ólafsdóttir, Kristin Probst-Hensch, Nicole Ammann, Priska Weber, Till Kolossa-Gehring, Marike Esteban-López, Marta Castaño, Argelia Andersen, Helle Raun Schoeters, Greet |
author_sort |
Buekers, Jurgen |
title |
Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults |
title_short |
Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults |
title_full |
Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults |
title_fullStr |
Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults |
title_full_unstemmed |
Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults |
title_sort |
glyphosate and ampa in human urine of hbm4eu-aligned studies: part b adults |
publisher |
MDPI |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612135/ http://www.ncbi.nlm.nih.gov/pubmed/36287833 https://doi.org/10.3390/toxics10100552 |
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Iceland |
genre_facet |
Iceland |
op_source |
Toxics |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612135/ http://www.ncbi.nlm.nih.gov/pubmed/36287833 http://dx.doi.org/10.3390/toxics10100552 |
op_rights |
© 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/toxics10100552 |
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Toxics |
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10 |
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10 |
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552 |
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1766041141479735296 |