Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study
OBJECTIVE: To investigate the relation between serum 25-hydroxyvitamin D (s-25(OH)D) and subjective sleep measures in an Arctic population (69°N). METHODS: Cross-sectional data was collected from 21,083 individuals (aged ≥40 years) participating in the population based Tromsø Study: Tromsø7 (2015–20...
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ftpubmed:oai:pubmedcentral.nih.gov:9579360 2023-05-15T14:56:35+02:00 Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study Larsen, A.U. Hopstock, L.A. Jorde, R. Grimnes, G. 2022-09-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579360/ https://doi.org/10.1016/j.sleepx.2022.100056 en eng Elsevier http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579360/ http://dx.doi.org/10.1016/j.sleepx.2022.100056 © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). CC-BY-NC-ND Sleep Med X Article Text 2022 ftpubmed https://doi.org/10.1016/j.sleepx.2022.100056 2022-10-23T01:11:29Z OBJECTIVE: To investigate the relation between serum 25-hydroxyvitamin D (s-25(OH)D) and subjective sleep measures in an Arctic population (69°N). METHODS: Cross-sectional data was collected from 21,083 individuals (aged ≥40 years) participating in the population based Tromsø Study: Tromsø7 (2015–2016). The present study included 20,438 participants, after having excluded respondents missing data on s-25(OH)D (n = 161) and/or subjective sleep measures (including sleep duration, insomnia, and daytime sleepiness)(n = 490). Based on s-25(OH)D (assessed using LC-MS/MS), participants were grouped as deficient (<30 nmol/L), insufficient (30–49.9 nmol/L), sufficient (50–75 nmol/L), or high (>75 nmol/L). Sleep duration was grouped as inadequate (ISD) if < 7 or ≥9 h. Linear and logistic regression were used to calculate unstandardized β-values and odds ratios [95% confidence intervals]. The analyses were adjusted for season, age, BMI, lifestyle factors and relevant comorbidities. RESULTS: In both men and women, s-25(OH)D was positively associated with sleep duration, and compared to the sufficient s-25(OH)D group, the insufficient s-25(OH)D group reported significantly shorter sleep duration in both sexes. There was an increased odds of ISD in both men and women but adjusted for confounding factors this was only significant in women (1.16 [1.03, 1.32], p = .017). In men, there were no significant associations between s-25(OH)D and the remaining sleep measures. Women in the high s-25(OH)D group had lower ESS-scores (−0.28 [-0.47, −0.08], p = .006), but higher odds of insomnia (1.16 [1.01, 1.33], p = .036) compared to women in the sufficient group. CONCLUSIONS: In this Arctic population, a tenuous association was found between s-25(OH)D and subjective sleep measures, predominantly in women. Text Arctic Arctic Population Tromsø PubMed Central (PMC) Arctic Tromsø Sleep Medicine: X 4 100056 |
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Article Larsen, A.U. Hopstock, L.A. Jorde, R. Grimnes, G. Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
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Article |
description |
OBJECTIVE: To investigate the relation between serum 25-hydroxyvitamin D (s-25(OH)D) and subjective sleep measures in an Arctic population (69°N). METHODS: Cross-sectional data was collected from 21,083 individuals (aged ≥40 years) participating in the population based Tromsø Study: Tromsø7 (2015–2016). The present study included 20,438 participants, after having excluded respondents missing data on s-25(OH)D (n = 161) and/or subjective sleep measures (including sleep duration, insomnia, and daytime sleepiness)(n = 490). Based on s-25(OH)D (assessed using LC-MS/MS), participants were grouped as deficient (<30 nmol/L), insufficient (30–49.9 nmol/L), sufficient (50–75 nmol/L), or high (>75 nmol/L). Sleep duration was grouped as inadequate (ISD) if < 7 or ≥9 h. Linear and logistic regression were used to calculate unstandardized β-values and odds ratios [95% confidence intervals]. The analyses were adjusted for season, age, BMI, lifestyle factors and relevant comorbidities. RESULTS: In both men and women, s-25(OH)D was positively associated with sleep duration, and compared to the sufficient s-25(OH)D group, the insufficient s-25(OH)D group reported significantly shorter sleep duration in both sexes. There was an increased odds of ISD in both men and women but adjusted for confounding factors this was only significant in women (1.16 [1.03, 1.32], p = .017). In men, there were no significant associations between s-25(OH)D and the remaining sleep measures. Women in the high s-25(OH)D group had lower ESS-scores (−0.28 [-0.47, −0.08], p = .006), but higher odds of insomnia (1.16 [1.01, 1.33], p = .036) compared to women in the sufficient group. CONCLUSIONS: In this Arctic population, a tenuous association was found between s-25(OH)D and subjective sleep measures, predominantly in women. |
format |
Text |
author |
Larsen, A.U. Hopstock, L.A. Jorde, R. Grimnes, G. |
author_facet |
Larsen, A.U. Hopstock, L.A. Jorde, R. Grimnes, G. |
author_sort |
Larsen, A.U. |
title |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_short |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_full |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_fullStr |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_full_unstemmed |
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study |
title_sort |
associations of serum 25-hydroxyvitamin d and subjective sleep measures in an arctic population: insights from the population-based tromsø study |
publisher |
Elsevier |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579360/ https://doi.org/10.1016/j.sleepx.2022.100056 |
geographic |
Arctic Tromsø |
geographic_facet |
Arctic Tromsø |
genre |
Arctic Arctic Population Tromsø |
genre_facet |
Arctic Arctic Population Tromsø |
op_source |
Sleep Med X |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579360/ http://dx.doi.org/10.1016/j.sleepx.2022.100056 |
op_rights |
© 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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CC-BY-NC-ND |
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https://doi.org/10.1016/j.sleepx.2022.100056 |
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Sleep Medicine: X |
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4 |
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100056 |
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