Hypericum Genus as a Natural Source for Biologically Active Compounds
Hypericum L. genus plants are distributed worldwide, with numerous species identified throughout all continents, except Antarctica. These plant species are currently used in various systems of traditional medicine to treat mild depression, wounds and burns, diarrhea, pain, fevers, and their secondar...
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ftpubmed:oai:pubmedcentral.nih.gov:9573133 2023-05-15T13:44:28+02:00 Hypericum Genus as a Natural Source for Biologically Active Compounds Caldeira, Gonçalo Infante Gouveia, Luís Pleno Serrano, Rita Silva, Olga Duarte 2022-09-26 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573133/ http://www.ncbi.nlm.nih.gov/pubmed/36235373 https://doi.org/10.3390/plants11192509 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573133/ http://www.ncbi.nlm.nih.gov/pubmed/36235373 http://dx.doi.org/10.3390/plants11192509 © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY Plants (Basel) Systematic Review Text 2022 ftpubmed https://doi.org/10.3390/plants11192509 2022-10-23T00:56:28Z Hypericum L. genus plants are distributed worldwide, with numerous species identified throughout all continents, except Antarctica. These plant species are currently used in various systems of traditional medicine to treat mild depression, wounds and burns, diarrhea, pain, fevers, and their secondary metabolites previously shown, and the in vitro and/or in vivo cytotoxic, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, and hepatoprotective activities, as well as the acetylcholinesterase and monoamine oxidase inhibitory activities. We conducted a systematic bibliographic search according to the Cochrane Collaboration guidelines to answer the question: “What is known about plants of Hypericum genus as a source of natural products with potential clinical biological activity?” We documented 414 different natural products with confirmed in vitro/in vivo biological activities, and 58 different Hypericum plant species as sources for these natural products. Phloroglucinols, acylphloroglucinols, xanthones, and benzophenones were the main chemical classes identified. The selective cytotoxicity against tumor cells, cell protection, anti-inflammatory, antimicrobial, antidepressant, anti-Alzheimer’s, and adipogenesis-inhibition biological activities are described. Acylphloroglucinols were the most frequent compounds with anticancer and cell-protection mechanisms. To date, no work has been published with a full descriptive list directly relating secondary metabolites to their species of origin, plant parts used, extraction methodologies, mechanisms of action, and biological activities. Text Antarc* Antarctica PubMed Central (PMC) Plants 11 19 2509 |
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Systematic Review |
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Systematic Review Caldeira, Gonçalo Infante Gouveia, Luís Pleno Serrano, Rita Silva, Olga Duarte Hypericum Genus as a Natural Source for Biologically Active Compounds |
topic_facet |
Systematic Review |
description |
Hypericum L. genus plants are distributed worldwide, with numerous species identified throughout all continents, except Antarctica. These plant species are currently used in various systems of traditional medicine to treat mild depression, wounds and burns, diarrhea, pain, fevers, and their secondary metabolites previously shown, and the in vitro and/or in vivo cytotoxic, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, and hepatoprotective activities, as well as the acetylcholinesterase and monoamine oxidase inhibitory activities. We conducted a systematic bibliographic search according to the Cochrane Collaboration guidelines to answer the question: “What is known about plants of Hypericum genus as a source of natural products with potential clinical biological activity?” We documented 414 different natural products with confirmed in vitro/in vivo biological activities, and 58 different Hypericum plant species as sources for these natural products. Phloroglucinols, acylphloroglucinols, xanthones, and benzophenones were the main chemical classes identified. The selective cytotoxicity against tumor cells, cell protection, anti-inflammatory, antimicrobial, antidepressant, anti-Alzheimer’s, and adipogenesis-inhibition biological activities are described. Acylphloroglucinols were the most frequent compounds with anticancer and cell-protection mechanisms. To date, no work has been published with a full descriptive list directly relating secondary metabolites to their species of origin, plant parts used, extraction methodologies, mechanisms of action, and biological activities. |
format |
Text |
author |
Caldeira, Gonçalo Infante Gouveia, Luís Pleno Serrano, Rita Silva, Olga Duarte |
author_facet |
Caldeira, Gonçalo Infante Gouveia, Luís Pleno Serrano, Rita Silva, Olga Duarte |
author_sort |
Caldeira, Gonçalo Infante |
title |
Hypericum Genus as a Natural Source for Biologically Active Compounds |
title_short |
Hypericum Genus as a Natural Source for Biologically Active Compounds |
title_full |
Hypericum Genus as a Natural Source for Biologically Active Compounds |
title_fullStr |
Hypericum Genus as a Natural Source for Biologically Active Compounds |
title_full_unstemmed |
Hypericum Genus as a Natural Source for Biologically Active Compounds |
title_sort |
hypericum genus as a natural source for biologically active compounds |
publisher |
MDPI |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573133/ http://www.ncbi.nlm.nih.gov/pubmed/36235373 https://doi.org/10.3390/plants11192509 |
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Antarc* Antarctica |
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Antarc* Antarctica |
op_source |
Plants (Basel) |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573133/ http://www.ncbi.nlm.nih.gov/pubmed/36235373 http://dx.doi.org/10.3390/plants11192509 |
op_rights |
© 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
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https://doi.org/10.3390/plants11192509 |
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Plants |
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11 |
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19 |
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2509 |
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1766202002047500288 |