Impact of a Prenatal Vitamin D Supplementation Program on Vitamin D Deficiency, Rickets and Early Childhood Caries in an Alaska Native Population
Background: Early childhood rickets increased in Alaska Native children after decreases in vitamin D-rich subsistence diet in childbearing-aged women. We evaluated the impact of routine prenatal vitamin D supplementation initiated in Alaska’s Yukon Kuskokwim Delta in Fall 2016. Methods: We queried e...
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ftpubmed:oai:pubmedcentral.nih.gov:9570803 2023-05-15T17:05:40+02:00 Impact of a Prenatal Vitamin D Supplementation Program on Vitamin D Deficiency, Rickets and Early Childhood Caries in an Alaska Native Population Singleton, Rosalyn J. Day, Gretchen M. Thomas, Timothy K. Klejka, Joseph A. Desnoyers, Christine A. McIntyre, Melanie N. P. Compton, David M. Thummel, Kenneth E. Schroth, Robert J. Ward, Leanne M. Lenaker, Dane C. Lescher, Rachel K. McLaughlin, Joseph B. 2022-09-22 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570803/ http://www.ncbi.nlm.nih.gov/pubmed/36235588 https://doi.org/10.3390/nu14193935 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570803/ http://www.ncbi.nlm.nih.gov/pubmed/36235588 http://dx.doi.org/10.3390/nu14193935 © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY Nutrients Article Text 2022 ftpubmed https://doi.org/10.3390/nu14193935 2022-10-23T00:49:25Z Background: Early childhood rickets increased in Alaska Native children after decreases in vitamin D-rich subsistence diet in childbearing-aged women. We evaluated the impact of routine prenatal vitamin D supplementation initiated in Alaska’s Yukon Kuskokwim Delta in Fall 2016. Methods: We queried electronic health records of prenatal women with 25(OH) vitamin D testing during the period 2015–2019. We evaluated 25(OH)D concentrations, vitamin D(3) supplement refills, and decayed, missing, and filled teeth (dmft) scores and rickets in offspring. Results: Mean 25(OH)D concentrations increased 36.5% from pre- to post-supplementation; the percentage with deficient 25(OH)D decreased by 66.4%. Women with ≥ 60 vitamin D(3) refill days had higher late pregnancy 25(OH)D concentrations than those with no refill days (p < 0.0001). Women with late pregnancy insufficient 25(OH)D concentrations had offspring with higher dmft scores than those with sufficient 25(OH)D (RR 1.3, p < 0.0001). Three children were diagnosed with nutritional rickets during the period 2001–2021, and none after 2017. Conclusions: These findings suggest that prenatal vitamin D supplementation can improve childhood outcomes in high-risk populations with high rates of rickets. Text Kuskokwim Alaska Yukon PubMed Central (PMC) Yukon Nutrients 14 19 3935 |
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Article Singleton, Rosalyn J. Day, Gretchen M. Thomas, Timothy K. Klejka, Joseph A. Desnoyers, Christine A. McIntyre, Melanie N. P. Compton, David M. Thummel, Kenneth E. Schroth, Robert J. Ward, Leanne M. Lenaker, Dane C. Lescher, Rachel K. McLaughlin, Joseph B. Impact of a Prenatal Vitamin D Supplementation Program on Vitamin D Deficiency, Rickets and Early Childhood Caries in an Alaska Native Population |
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description |
Background: Early childhood rickets increased in Alaska Native children after decreases in vitamin D-rich subsistence diet in childbearing-aged women. We evaluated the impact of routine prenatal vitamin D supplementation initiated in Alaska’s Yukon Kuskokwim Delta in Fall 2016. Methods: We queried electronic health records of prenatal women with 25(OH) vitamin D testing during the period 2015–2019. We evaluated 25(OH)D concentrations, vitamin D(3) supplement refills, and decayed, missing, and filled teeth (dmft) scores and rickets in offspring. Results: Mean 25(OH)D concentrations increased 36.5% from pre- to post-supplementation; the percentage with deficient 25(OH)D decreased by 66.4%. Women with ≥ 60 vitamin D(3) refill days had higher late pregnancy 25(OH)D concentrations than those with no refill days (p < 0.0001). Women with late pregnancy insufficient 25(OH)D concentrations had offspring with higher dmft scores than those with sufficient 25(OH)D (RR 1.3, p < 0.0001). Three children were diagnosed with nutritional rickets during the period 2001–2021, and none after 2017. Conclusions: These findings suggest that prenatal vitamin D supplementation can improve childhood outcomes in high-risk populations with high rates of rickets. |
format |
Text |
author |
Singleton, Rosalyn J. Day, Gretchen M. Thomas, Timothy K. Klejka, Joseph A. Desnoyers, Christine A. McIntyre, Melanie N. P. Compton, David M. Thummel, Kenneth E. Schroth, Robert J. Ward, Leanne M. Lenaker, Dane C. Lescher, Rachel K. McLaughlin, Joseph B. |
author_facet |
Singleton, Rosalyn J. Day, Gretchen M. Thomas, Timothy K. Klejka, Joseph A. Desnoyers, Christine A. McIntyre, Melanie N. P. Compton, David M. Thummel, Kenneth E. Schroth, Robert J. Ward, Leanne M. Lenaker, Dane C. Lescher, Rachel K. McLaughlin, Joseph B. |
author_sort |
Singleton, Rosalyn J. |
title |
Impact of a Prenatal Vitamin D Supplementation Program on Vitamin D Deficiency, Rickets and Early Childhood Caries in an Alaska Native Population |
title_short |
Impact of a Prenatal Vitamin D Supplementation Program on Vitamin D Deficiency, Rickets and Early Childhood Caries in an Alaska Native Population |
title_full |
Impact of a Prenatal Vitamin D Supplementation Program on Vitamin D Deficiency, Rickets and Early Childhood Caries in an Alaska Native Population |
title_fullStr |
Impact of a Prenatal Vitamin D Supplementation Program on Vitamin D Deficiency, Rickets and Early Childhood Caries in an Alaska Native Population |
title_full_unstemmed |
Impact of a Prenatal Vitamin D Supplementation Program on Vitamin D Deficiency, Rickets and Early Childhood Caries in an Alaska Native Population |
title_sort |
impact of a prenatal vitamin d supplementation program on vitamin d deficiency, rickets and early childhood caries in an alaska native population |
publisher |
MDPI |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570803/ http://www.ncbi.nlm.nih.gov/pubmed/36235588 https://doi.org/10.3390/nu14193935 |
geographic |
Yukon |
geographic_facet |
Yukon |
genre |
Kuskokwim Alaska Yukon |
genre_facet |
Kuskokwim Alaska Yukon |
op_source |
Nutrients |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570803/ http://www.ncbi.nlm.nih.gov/pubmed/36235588 http://dx.doi.org/10.3390/nu14193935 |
op_rights |
© 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/nu14193935 |
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Nutrients |
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14 |
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19 |
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3935 |
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1766060355692265472 |