Resveratrol Improves the Digestive Ability and the Intestinal Health of Siberian Sturgeon

• Published in: International Journal of Molecular Sciences
• Main Authors: Yang, Shiyong, Xu, Wenqiang, Feng, Langkun, Zhang, Chaoyang, Yan, Chaozhan, Zhang, Jiajin, Lai, Jiansheng, Yan, Taiming, He, Zhi, Du, Xiaogang, Du, Zongjun, Luo, Wei, Huang, Xiaoli, Wu, Jiayun, Li, Yunkun
• Format: Text
• Language: English
• Published: MDPI 2022
• Subjects: Article; Siberian sturgeon
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569792/; http://www.ncbi.nlm.nih.gov/pubmed/36233280; https://doi.org/10.3390/ijms231911977

The lack of detailed information on nutritional requirement results in limited feeding in Siberian sturgeon. In this study, resveratrol, a versatile natural extract, was supplemented in the daily diet, and the digestive ability and microbiome were evaluated in the duodena and valvular intestines of Siberian sturgeon. The results showed that resveratrol increased the activity of pepsin, α-amylase, and lipase, which was positively associated with an increase in the digestive ability, but it did not influence the final body weight. Resveratrol improved the digestive ability probably by distinctly enhancing intestinal villus height. Microbiome analysis revealed that resveratrol changed the abundance and composition of the microbial community in the intestine, principally in the duodenum. Random forests analysis found that resveratrol significantly downregulated the abundance of potential pathogens (Citrobacter freundii, Vibrio rumoiensis, and Brucella melitensis), suggesting that resveratrol may also improve intestinal health. In summary, our study revealed that resveratrol improved digestive ability and intestinal health, which can contribute to the development of functional feed in Siberian sturgeon.