Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study
INTRODUCTION: This population‐based follow‐up study investigated the comorbidities, medication use, and healthcare services among women with polycystic ovary syndrome (PCOS) at age 46 years. MATERIAL AND METHODS: The study population derived from the Northern Finland Birth Cohort 1966 and consisted...
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ftpubmed:oai:pubmedcentral.nih.gov:9564432 2023-05-15T17:42:37+02:00 Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study Kujanpää, Linda Arffman, Riikka K. Pesonen, Paula Korhonen, Elisa Karjula, Salla Järvelin, Marjo‐Riitta Franks, Stephen Tapanainen, Juha S. Morin‐Papunen, Laure Piltonen, Terhi T. 2022-06-08 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564432/ http://www.ncbi.nlm.nih.gov/pubmed/35673942 https://doi.org/10.1111/aogs.14382 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564432/ http://www.ncbi.nlm.nih.gov/pubmed/35673942 http://dx.doi.org/10.1111/aogs.14382 © 2022 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. CC-BY Acta Obstet Gynecol Scand Epidemiology Text 2022 ftpubmed https://doi.org/10.1111/aogs.14382 2022-12-11T01:48:19Z INTRODUCTION: This population‐based follow‐up study investigated the comorbidities, medication use, and healthcare services among women with polycystic ovary syndrome (PCOS) at age 46 years. MATERIAL AND METHODS: The study population derived from the Northern Finland Birth Cohort 1966 and consisted of women reporting oligo/amenorrhea and hirsutism at age 31 years and/or a PCOS diagnosis by age 46 years (n = 246) and controls without PCOS symptoms or diagnosis (n = 1573), referred to as non‐PCOS women. The main outcome measures were self‐reported data on symptoms, diagnosed diseases, and medication and healthcare service use at the age of 46 years. RESULTS: Overall morbidity risk was increased by 35% (risk ratio [RR] 1.35, 95% confidence interval [CI] 1.16–1.57) and medication use by 27% [RR 1.27, 95% CI 1.08–1.50) compared with non‐PCOS women, and the risk remained after adjusting for body mass index. Diagnoses with increased prevalence in women with PCOS were migraine, hypertension, tendinitis, osteoarthritis, fractures, and endometriosis. PCOS was also associated with autoimmune diseases and recurrent upper respiratory tract infections and symptoms. Interestingly, healthcare service use did not differ between the study groups after adjusting for body mass index. CONCLUSIONS: Women with PCOS are burdened with multimorbidity and higher medication use, independent of body mass index. Text Northern Finland PubMed Central (PMC) Acta Obstetricia et Gynecologica Scandinavica 101 7 728 736 |
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Epidemiology |
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Epidemiology Kujanpää, Linda Arffman, Riikka K. Pesonen, Paula Korhonen, Elisa Karjula, Salla Järvelin, Marjo‐Riitta Franks, Stephen Tapanainen, Juha S. Morin‐Papunen, Laure Piltonen, Terhi T. Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study |
topic_facet |
Epidemiology |
description |
INTRODUCTION: This population‐based follow‐up study investigated the comorbidities, medication use, and healthcare services among women with polycystic ovary syndrome (PCOS) at age 46 years. MATERIAL AND METHODS: The study population derived from the Northern Finland Birth Cohort 1966 and consisted of women reporting oligo/amenorrhea and hirsutism at age 31 years and/or a PCOS diagnosis by age 46 years (n = 246) and controls without PCOS symptoms or diagnosis (n = 1573), referred to as non‐PCOS women. The main outcome measures were self‐reported data on symptoms, diagnosed diseases, and medication and healthcare service use at the age of 46 years. RESULTS: Overall morbidity risk was increased by 35% (risk ratio [RR] 1.35, 95% confidence interval [CI] 1.16–1.57) and medication use by 27% [RR 1.27, 95% CI 1.08–1.50) compared with non‐PCOS women, and the risk remained after adjusting for body mass index. Diagnoses with increased prevalence in women with PCOS were migraine, hypertension, tendinitis, osteoarthritis, fractures, and endometriosis. PCOS was also associated with autoimmune diseases and recurrent upper respiratory tract infections and symptoms. Interestingly, healthcare service use did not differ between the study groups after adjusting for body mass index. CONCLUSIONS: Women with PCOS are burdened with multimorbidity and higher medication use, independent of body mass index. |
format |
Text |
author |
Kujanpää, Linda Arffman, Riikka K. Pesonen, Paula Korhonen, Elisa Karjula, Salla Järvelin, Marjo‐Riitta Franks, Stephen Tapanainen, Juha S. Morin‐Papunen, Laure Piltonen, Terhi T. |
author_facet |
Kujanpää, Linda Arffman, Riikka K. Pesonen, Paula Korhonen, Elisa Karjula, Salla Järvelin, Marjo‐Riitta Franks, Stephen Tapanainen, Juha S. Morin‐Papunen, Laure Piltonen, Terhi T. |
author_sort |
Kujanpää, Linda |
title |
Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study |
title_short |
Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study |
title_full |
Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study |
title_fullStr |
Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study |
title_full_unstemmed |
Women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: A population‐based cohort study |
title_sort |
women with polycystic ovary syndrome are burdened with multimorbidity and medication use independent of body mass index at late fertile age: a population‐based cohort study |
publisher |
John Wiley and Sons Inc. |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564432/ http://www.ncbi.nlm.nih.gov/pubmed/35673942 https://doi.org/10.1111/aogs.14382 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Acta Obstet Gynecol Scand |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564432/ http://www.ncbi.nlm.nih.gov/pubmed/35673942 http://dx.doi.org/10.1111/aogs.14382 |
op_rights |
© 2022 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1111/aogs.14382 |
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Acta Obstetricia et Gynecologica Scandinavica |
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101 |
container_issue |
7 |
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728 |
op_container_end_page |
736 |
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1766144503769464832 |