Respiratory function and CT abnormalities among survivors of COVID-19 pneumonia: a nationwide follow-up study
INTRODUCTION: Considering the pulmonary burden caused by acute COVID-19, questions remain of respiratory consequences after recovery. The aim of the study was to describe respiratory function of COVID-19 pneumonia survivors at mid-term follow-up (median 68 days) and assess whether impairments were p...
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ftpubmed:oai:pubmedcentral.nih.gov:9556742 2023-05-15T16:51:46+02:00 Respiratory function and CT abnormalities among survivors of COVID-19 pneumonia: a nationwide follow-up study Axelsson, Gisli Thor Halldorsson, Arnljotur Bjorn Jonsson, Helgi Mar Eythorsson, Elias Sigurdardottir, Sigridur Erla Hardardottir, Hronn Gudmundsson, Gunnar Hansdottir, Sif 2022-10-10 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556742/ http://www.ncbi.nlm.nih.gov/pubmed/36216402 https://doi.org/10.1136/bmjresp-2022-001347 en eng BMJ Publishing Group http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556742/ http://www.ncbi.nlm.nih.gov/pubmed/36216402 http://dx.doi.org/10.1136/bmjresp-2022-001347 © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . CC-BY-NC BMJ Open Respir Res Respiratory Infection Text 2022 ftpubmed https://doi.org/10.1136/bmjresp-2022-001347 2022-10-16T01:00:06Z INTRODUCTION: Considering the pulmonary burden caused by acute COVID-19, questions remain of respiratory consequences after recovery. The aim of the study was to describe respiratory function of COVID-19 pneumonia survivors at mid-term follow-up (median 68 days) and assess whether impairments were predicted by acute illness severity or residual CT abnormalities. METHODS: Residents of Iceland that had COVID-19 and oxygen saturation ≤94% from 28 February 2020 to 30 April 2021 were offered a clinical follow-up visit with an interview, a 6 min walk test (6MWT), spirometry with gas exchange measurement and chest CT. The results of these examinations were described, grouped by the level of care during acute illness. The associations of disease severity and CT abnormalities at follow-up with subjective dyspnoea, 6MWT results and lung function test results were estimated with regression analyses. RESULTS: Of 190 eligible patients, 164 (86%) participated in the study. Of those, 32 had never been admitted to hospital, 103 were admitted to hospital without intensive care and 29 had required intensive care. At a follow-up, need for intensive care during acute illness was associated with shorter walking distance on 6MWT, lower oxygen saturation and lower DL(CO). Imaging abnormalities at follow-up were observed for most participants (74%) and the magnitude of these changes was associated with decrements in 6MWT distance, oxygen saturation, forced vital capacity and DL(CO). CONCLUSIONS: The findings show that impaired exercise capacity and lung physiology at follow-up were primarily observed for patients with COVID-19 pneumonia that required intensive care treatment and/or had persistent imaging abnormalities. Text Iceland PubMed Central (PMC) BMJ Open Respiratory Research 9 1 e001347 |
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Respiratory Infection |
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Respiratory Infection Axelsson, Gisli Thor Halldorsson, Arnljotur Bjorn Jonsson, Helgi Mar Eythorsson, Elias Sigurdardottir, Sigridur Erla Hardardottir, Hronn Gudmundsson, Gunnar Hansdottir, Sif Respiratory function and CT abnormalities among survivors of COVID-19 pneumonia: a nationwide follow-up study |
topic_facet |
Respiratory Infection |
description |
INTRODUCTION: Considering the pulmonary burden caused by acute COVID-19, questions remain of respiratory consequences after recovery. The aim of the study was to describe respiratory function of COVID-19 pneumonia survivors at mid-term follow-up (median 68 days) and assess whether impairments were predicted by acute illness severity or residual CT abnormalities. METHODS: Residents of Iceland that had COVID-19 and oxygen saturation ≤94% from 28 February 2020 to 30 April 2021 were offered a clinical follow-up visit with an interview, a 6 min walk test (6MWT), spirometry with gas exchange measurement and chest CT. The results of these examinations were described, grouped by the level of care during acute illness. The associations of disease severity and CT abnormalities at follow-up with subjective dyspnoea, 6MWT results and lung function test results were estimated with regression analyses. RESULTS: Of 190 eligible patients, 164 (86%) participated in the study. Of those, 32 had never been admitted to hospital, 103 were admitted to hospital without intensive care and 29 had required intensive care. At a follow-up, need for intensive care during acute illness was associated with shorter walking distance on 6MWT, lower oxygen saturation and lower DL(CO). Imaging abnormalities at follow-up were observed for most participants (74%) and the magnitude of these changes was associated with decrements in 6MWT distance, oxygen saturation, forced vital capacity and DL(CO). CONCLUSIONS: The findings show that impaired exercise capacity and lung physiology at follow-up were primarily observed for patients with COVID-19 pneumonia that required intensive care treatment and/or had persistent imaging abnormalities. |
format |
Text |
author |
Axelsson, Gisli Thor Halldorsson, Arnljotur Bjorn Jonsson, Helgi Mar Eythorsson, Elias Sigurdardottir, Sigridur Erla Hardardottir, Hronn Gudmundsson, Gunnar Hansdottir, Sif |
author_facet |
Axelsson, Gisli Thor Halldorsson, Arnljotur Bjorn Jonsson, Helgi Mar Eythorsson, Elias Sigurdardottir, Sigridur Erla Hardardottir, Hronn Gudmundsson, Gunnar Hansdottir, Sif |
author_sort |
Axelsson, Gisli Thor |
title |
Respiratory function and CT abnormalities among survivors of COVID-19 pneumonia: a nationwide follow-up study |
title_short |
Respiratory function and CT abnormalities among survivors of COVID-19 pneumonia: a nationwide follow-up study |
title_full |
Respiratory function and CT abnormalities among survivors of COVID-19 pneumonia: a nationwide follow-up study |
title_fullStr |
Respiratory function and CT abnormalities among survivors of COVID-19 pneumonia: a nationwide follow-up study |
title_full_unstemmed |
Respiratory function and CT abnormalities among survivors of COVID-19 pneumonia: a nationwide follow-up study |
title_sort |
respiratory function and ct abnormalities among survivors of covid-19 pneumonia: a nationwide follow-up study |
publisher |
BMJ Publishing Group |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556742/ http://www.ncbi.nlm.nih.gov/pubmed/36216402 https://doi.org/10.1136/bmjresp-2022-001347 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
BMJ Open Respir Res |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556742/ http://www.ncbi.nlm.nih.gov/pubmed/36216402 http://dx.doi.org/10.1136/bmjresp-2022-001347 |
op_rights |
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1136/bmjresp-2022-001347 |
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BMJ Open Respiratory Research |
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9 |
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1 |
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e001347 |
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1766041873123639296 |