Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021

• Published in: JAMA
• Main Authors: Wulf Hanson, Sarah, Abbafati, Cristiana, Aerts, Joachim G., Al-Aly, Ziyad, Ashbaugh, Charlie, Ballouz, Tala, Blyuss, Oleg, Bobkova, Polina, Bonsel, Gouke, Borzakova, Svetlana, Buonsenso, Danilo, Butnaru, Denis, Carter, Austin, Chu, Helen, De Rose, Cristina, Diab, Mohamed Mustafa, Ekbom, Emil, El Tantawi, Maha, Fomin, Victor, Frithiof, Robert, Gamirova, Aysylu, Glybochko, Petr V., Haagsma, Juanita A., Haghjooy Javanmard, Shaghayegh, Hamilton, Erin B., Harris, Gabrielle, Heijenbrok-Kal, Majanka H., Helbok, Raimund, Hellemons, Merel E., Hillus, David, Huijts, Susanne M., Hultström, Michael, Jassat, Waasila, Kurth, Florian, Larsson, Ing-Marie, Lipcsey, Miklós, Liu, Chelsea, Loflin, Callan D., Malinovschi, Andrei, Mao, Wenhui, Mazankova, Lyudmila, McCulloch, Denise, Menges, Dominik, Mohammadifard, Noushin, Munblit, Daniel, Nekliudov, Nikita A., Ogbuoji, Osondu, Osmanov, Ismail M., Peñalvo, José L., Petersen, Maria Skaalum, Puhan, Milo A., Rahman, Mujibur, Rass, Verena, Reinig, Nickolas, Ribbers, Gerard M., Ricchiuto, Antonia, Rubertsson, Sten, Samitova, Elmira, Sarrafzadegan, Nizal, Shikhaleva, Anastasia, Simpson, Kyle E., Sinatti, Dario, Soriano, Joan B., Spiridonova, Ekaterina, Steinbeis, Fridolin, Svistunov, Andrey A., Valentini, Piero, van de Water, Brittney J., van den Berg-Emons, Rita, Wallin, Ewa, Witzenrath, Martin, Wu, Yifan, Xu, Hanzhang, Zoller, Thomas, Adolph, Christopher, Albright, James, Amlag, Joanne O., Aravkin, Aleksandr Y., Bang-Jensen, Bree L., Bisignano, Catherine, Castellano, Rachel, Castro, Emma, Chakrabarti, Suman, Collins, James K., Dai, Xiaochen, Daoud, Farah, Dapper, Carolyn, Deen, Amanda, Duncan, Bruce B., Erickson, Megan, Ewald, Samuel B., Ferrari, Alize J., Flaxman, Abraham D., Fullman, Nancy, Gamkrelidze, Amiran, Giles, John R., Guo, Gaorui, Hay, Simon I., He, Jiawei, Helak, Monika, Hulland, Erin N., Kereselidze, Maia, Krohn, Kris J., Lazzar-Atwood, Alice, Lindstrom, Akiaja, Lozano, Rafael, Malta, Deborah Carvalho, Månsson, Johan, Mantilla Herrera, Ana M., Mokdad, Ali H., Monasta, Lorenzo, Nomura, Shuhei, Pasovic, Maja, Pigott, David M., Reiner, Robert C., Reinke, Grace, Ribeiro, Antonio Luiz P., Santomauro, Damian Francesco, Sholokhov, Aleksei, Spurlock, Emma Elizabeth, Walcott, Rebecca, Walker, Ally, Wiysonge, Charles Shey, Zheng, Peng, Bettger, Janet Prvu, Murray, Christopher J. L., Vos, Theo
• Format: Text
• Language: English
• Published: American Medical Association 2022
• Subjects: Original Investigation; Faroe Islands
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552043/; http://www.ncbi.nlm.nih.gov/pubmed/36215063; https://doi.org/10.1001/jama.2022.18931

IMPORTANCE: Some individuals experience persistent symptoms after initial symptomatic SARS-CoV-2 infection (often referred to as Long COVID). OBJECTIVE: To estimate the proportion of males and females with COVID-19, younger or older than 20 years of age, who had Long COVID symptoms in 2020 and 2021 and their Long COVID symptom duration. DESIGN, SETTING, AND PARTICIPANTS: Bayesian meta-regression and pooling of 54 studies and 2 medical record databases with data for 1.2 million individuals (from 22 countries) who had symptomatic SARS-CoV-2 infection. Of the 54 studies, 44 were published and 10 were collaborating cohorts (conducted in Austria, the Faroe Islands, Germany, Iran, Italy, the Netherlands, Russia, Sweden, Switzerland, and the US). The participant data were derived from the 44 published studies (10 501 hospitalized individuals and 42 891 nonhospitalized individuals), the 10 collaborating cohort studies (10 526 and 1906), and the 2 US electronic medical record databases (250 928 and 846 046). Data collection spanned March 2020 to January 2022. EXPOSURES: Symptomatic SARS-CoV-2 infection. MAIN OUTCOMES AND MEASURES: Proportion of individuals with at least 1 of the 3 self-reported Long COVID symptom clusters (persistent fatigue with bodily pain or mood swings; cognitive problems; or ongoing respiratory problems) 3 months after SARS-CoV-2 infection in 2020 and 2021, estimated separately for hospitalized and nonhospitalized individuals aged 20 years or older by sex and for both sexes of nonhospitalized individuals younger than 20 years of age. RESULTS: A total of 1.2 million individuals who had symptomatic SARS-CoV-2 infection were included (mean age, 4-66 years; males, 26%-88%). In the modeled estimates, 6.2% (95% uncertainty interval [UI], 2.4%-13.3%) of individuals who had symptomatic SARS-CoV-2 infection experienced at least 1 of the 3 Long COVID symptom clusters in 2020 and 2021, including 3.2% (95% UI, 0.6%-10.0%) for persistent fatigue with bodily pain or mood swings, 3.7% (95% UI, 0.9%-9.6%) for ...