The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation
Shell color shows broad variation within mollusc species and despite information on the genetic pathways involved in shell construction and color has recently increased, more studies are needed to understand its genetic architecture. The common cockle (Cerastoderma edule) is a valuable species from...
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ftpubmed:oai:pubmedcentral.nih.gov:9551087 2023-05-15T17:41:27+02:00 The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation Hermida, Miguel Robledo, Diego Díaz, Seila Costas, Damián Bruzos, Alicia L. Blanco, Andrés Pardo, Belén G. Martínez, Paulino 2022-10-10 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551087/ http://www.ncbi.nlm.nih.gov/pubmed/36216849 https://doi.org/10.1038/s41598-022-21214-3 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551087/ http://www.ncbi.nlm.nih.gov/pubmed/36216849 http://dx.doi.org/10.1038/s41598-022-21214-3 © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . CC-BY Sci Rep Article Text 2022 ftpubmed https://doi.org/10.1038/s41598-022-21214-3 2022-10-16T00:48:38Z Shell color shows broad variation within mollusc species and despite information on the genetic pathways involved in shell construction and color has recently increased, more studies are needed to understand its genetic architecture. The common cockle (Cerastoderma edule) is a valuable species from ecological and commercial perspectives which shows important variation in shell color across Northeast Atlantic. In this study, we constructed a high-density genetic map, as a tool for screening common cockle genome, which was applied to ascertain the genetic basis of color variation in the species. The consensus genetic map comprised 19 linkage groups (LGs) in accordance with the cockle karyotype (2n = 38) and spanned 1073 cM, including 730 markers per LG and an inter-marker distance of 0.13 cM. Five full-sib families showing segregation for several color-associated traits were used for a genome-wide association study and a major QTL on chromosome 13 associated to different color-traits was detected. Mining on this genomic region revealed several candidate genes related to shell construction and color. A genomic region previously reported associated with divergent selection in cockle distribution overlapped with this QTL suggesting its putative role on adaptation. Text Northeast Atlantic PubMed Central (PMC) Scientific Reports 12 1 |
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Article Hermida, Miguel Robledo, Diego Díaz, Seila Costas, Damián Bruzos, Alicia L. Blanco, Andrés Pardo, Belén G. Martínez, Paulino The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation |
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Shell color shows broad variation within mollusc species and despite information on the genetic pathways involved in shell construction and color has recently increased, more studies are needed to understand its genetic architecture. The common cockle (Cerastoderma edule) is a valuable species from ecological and commercial perspectives which shows important variation in shell color across Northeast Atlantic. In this study, we constructed a high-density genetic map, as a tool for screening common cockle genome, which was applied to ascertain the genetic basis of color variation in the species. The consensus genetic map comprised 19 linkage groups (LGs) in accordance with the cockle karyotype (2n = 38) and spanned 1073 cM, including 730 markers per LG and an inter-marker distance of 0.13 cM. Five full-sib families showing segregation for several color-associated traits were used for a genome-wide association study and a major QTL on chromosome 13 associated to different color-traits was detected. Mining on this genomic region revealed several candidate genes related to shell construction and color. A genomic region previously reported associated with divergent selection in cockle distribution overlapped with this QTL suggesting its putative role on adaptation. |
format |
Text |
author |
Hermida, Miguel Robledo, Diego Díaz, Seila Costas, Damián Bruzos, Alicia L. Blanco, Andrés Pardo, Belén G. Martínez, Paulino |
author_facet |
Hermida, Miguel Robledo, Diego Díaz, Seila Costas, Damián Bruzos, Alicia L. Blanco, Andrés Pardo, Belén G. Martínez, Paulino |
author_sort |
Hermida, Miguel |
title |
The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation |
title_short |
The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation |
title_full |
The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation |
title_fullStr |
The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation |
title_full_unstemmed |
The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation |
title_sort |
first high-density genetic map of common cockle (cerastoderma edule) reveals a major qtl controlling shell color variation |
publisher |
Nature Publishing Group UK |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551087/ http://www.ncbi.nlm.nih.gov/pubmed/36216849 https://doi.org/10.1038/s41598-022-21214-3 |
genre |
Northeast Atlantic |
genre_facet |
Northeast Atlantic |
op_source |
Sci Rep |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551087/ http://www.ncbi.nlm.nih.gov/pubmed/36216849 http://dx.doi.org/10.1038/s41598-022-21214-3 |
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© The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
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CC-BY |
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https://doi.org/10.1038/s41598-022-21214-3 |
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