Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland
By the end of July 2021, the majority of the Icelandic population had received vaccination against COVID-19. In mid-July a wave of SARS-CoV-2 infections, dominated by the Delta variant, spread through the population, followed by an Omicron wave in December. A booster vaccination campaign was initiat...
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ftpubmed:oai:pubmedcentral.nih.gov:9517986 2023-05-15T16:49:57+02:00 Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland Norddahl, Gudmundur L. Melsted, Pall Gunnarsdottir, Kristbjorg Halldorsson, Gisli H. Olafsdottir, Thorunn A. Gylfason, Arnaldur Kristjansson, Mar Magnusson, Olafur T. Sulem, Patrick Gudbjartsson, Daniel F. Thorsteinsdottir, Unnur Jonsdottir, Ingileif Stefansson, Kari 2022-09-28 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517986/ https://doi.org/10.1038/s41467-022-33076-4 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517986/ http://dx.doi.org/10.1038/s41467-022-33076-4 © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . CC-BY Nat Commun Article Text 2022 ftpubmed https://doi.org/10.1038/s41467-022-33076-4 2022-10-02T01:01:20Z By the end of July 2021, the majority of the Icelandic population had received vaccination against COVID-19. In mid-July a wave of SARS-CoV-2 infections, dominated by the Delta variant, spread through the population, followed by an Omicron wave in December. A booster vaccination campaign was initiated to curb the spread of the virus. We estimate the risk of infection for different vaccine combinations using vaccination data from 276,028 persons and 963,557 qPCR tests for 277,687 persons. We measure anti-Spike-RBD antibody levels and ACE2-Spike binding inhibitory activity in 371 persons who received one of four recommended vaccination schedules with or without an mRNA vaccine booster. Overall, we find different antibody levels and inhibitory activity in recommended vaccination schedules, reflected in the observed risk of SARS-CoV-2 infections. We observe an increased protection following mRNA boosters, against both Omicron and Delta variant infections, although BNT162b2 boosters provide greater protection against Omicron than mRNA-1273 boosters. Text Iceland PubMed Central (PMC) Nature Communications 13 1 |
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Article Norddahl, Gudmundur L. Melsted, Pall Gunnarsdottir, Kristbjorg Halldorsson, Gisli H. Olafsdottir, Thorunn A. Gylfason, Arnaldur Kristjansson, Mar Magnusson, Olafur T. Sulem, Patrick Gudbjartsson, Daniel F. Thorsteinsdottir, Unnur Jonsdottir, Ingileif Stefansson, Kari Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland |
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By the end of July 2021, the majority of the Icelandic population had received vaccination against COVID-19. In mid-July a wave of SARS-CoV-2 infections, dominated by the Delta variant, spread through the population, followed by an Omicron wave in December. A booster vaccination campaign was initiated to curb the spread of the virus. We estimate the risk of infection for different vaccine combinations using vaccination data from 276,028 persons and 963,557 qPCR tests for 277,687 persons. We measure anti-Spike-RBD antibody levels and ACE2-Spike binding inhibitory activity in 371 persons who received one of four recommended vaccination schedules with or without an mRNA vaccine booster. Overall, we find different antibody levels and inhibitory activity in recommended vaccination schedules, reflected in the observed risk of SARS-CoV-2 infections. We observe an increased protection following mRNA boosters, against both Omicron and Delta variant infections, although BNT162b2 boosters provide greater protection against Omicron than mRNA-1273 boosters. |
format |
Text |
author |
Norddahl, Gudmundur L. Melsted, Pall Gunnarsdottir, Kristbjorg Halldorsson, Gisli H. Olafsdottir, Thorunn A. Gylfason, Arnaldur Kristjansson, Mar Magnusson, Olafur T. Sulem, Patrick Gudbjartsson, Daniel F. Thorsteinsdottir, Unnur Jonsdottir, Ingileif Stefansson, Kari |
author_facet |
Norddahl, Gudmundur L. Melsted, Pall Gunnarsdottir, Kristbjorg Halldorsson, Gisli H. Olafsdottir, Thorunn A. Gylfason, Arnaldur Kristjansson, Mar Magnusson, Olafur T. Sulem, Patrick Gudbjartsson, Daniel F. Thorsteinsdottir, Unnur Jonsdottir, Ingileif Stefansson, Kari |
author_sort |
Norddahl, Gudmundur L. |
title |
Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland |
title_short |
Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland |
title_full |
Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland |
title_fullStr |
Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland |
title_full_unstemmed |
Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland |
title_sort |
effect of booster vaccination against delta and omicron sars-cov-2 variants in iceland |
publisher |
Nature Publishing Group UK |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517986/ https://doi.org/10.1038/s41467-022-33076-4 |
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Iceland |
genre_facet |
Iceland |
op_source |
Nat Commun |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517986/ http://dx.doi.org/10.1038/s41467-022-33076-4 |
op_rights |
© The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
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CC-BY |
op_doi |
https://doi.org/10.1038/s41467-022-33076-4 |
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Nature Communications |
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13 |
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1 |
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1766040120827314176 |