Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has an extremely broad host range that includes hippopotami, which are phylogenetically closely related to whales. The cellular ACE2 receptor is one of the key determinants of the host range. Here, we found that ACE2s from several marine m...
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ftpubmed:oai:pubmedcentral.nih.gov:9517163 2023-05-15T17:12:51+02:00 Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals Li, Shihua Yang, Ruirui Zhang, Di Han, Pu Xu, Zepeng Chen, Qian Zhao, Runchu Zhao, Xin Qu, Xiao Zheng, Anqi Wang, Liang Li, Linjie Hu, Yu Zhang, Rong Su, Chao Niu, Sheng Zhang, Yanfang Qi, Jianxun Liu, Kefang Wang, Qihui Gao, George F 2022-06-23 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517163/ https://doi.org/10.1093/nsr/nwac122 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517163/ http://dx.doi.org/10.1093/nsr/nwac122 © The Author(s) 2022. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Natl Sci Rev Research Article Text 2022 ftpubmed https://doi.org/10.1093/nsr/nwac122 2022-10-02T00:59:09Z Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has an extremely broad host range that includes hippopotami, which are phylogenetically closely related to whales. The cellular ACE2 receptor is one of the key determinants of the host range. Here, we found that ACE2s from several marine mammals and hippopotami could efficiently bind to the receptor-binding domain (RBD) of both SARS-CoV and SARS-CoV-2 and facilitate the transduction of SARS-CoV and SARS-CoV-2 pseudoviruses into ACE2-expressing cells. We further resolved the cryo-electron microscopy complex structures of the minke whale ACE2 and sea lion ACE2, respectively, bound to the RBDs, revealing that they have similar binding modes to human ACE2 when it comes to the SARS-CoV-2 RBD and SARS-CoV RBD. Our results indicate that marine mammals could potentially be new victims or virus carriers of SARS-CoV-2, which deserves further careful investigation and study. It will provide an early warning for the prospective monitoring of marine mammals. Text minke whale PubMed Central (PMC) National Science Review 9 9 |
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Research Article Li, Shihua Yang, Ruirui Zhang, Di Han, Pu Xu, Zepeng Chen, Qian Zhao, Runchu Zhao, Xin Qu, Xiao Zheng, Anqi Wang, Liang Li, Linjie Hu, Yu Zhang, Rong Su, Chao Niu, Sheng Zhang, Yanfang Qi, Jianxun Liu, Kefang Wang, Qihui Gao, George F Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals |
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Research Article |
description |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has an extremely broad host range that includes hippopotami, which are phylogenetically closely related to whales. The cellular ACE2 receptor is one of the key determinants of the host range. Here, we found that ACE2s from several marine mammals and hippopotami could efficiently bind to the receptor-binding domain (RBD) of both SARS-CoV and SARS-CoV-2 and facilitate the transduction of SARS-CoV and SARS-CoV-2 pseudoviruses into ACE2-expressing cells. We further resolved the cryo-electron microscopy complex structures of the minke whale ACE2 and sea lion ACE2, respectively, bound to the RBDs, revealing that they have similar binding modes to human ACE2 when it comes to the SARS-CoV-2 RBD and SARS-CoV RBD. Our results indicate that marine mammals could potentially be new victims or virus carriers of SARS-CoV-2, which deserves further careful investigation and study. It will provide an early warning for the prospective monitoring of marine mammals. |
format |
Text |
author |
Li, Shihua Yang, Ruirui Zhang, Di Han, Pu Xu, Zepeng Chen, Qian Zhao, Runchu Zhao, Xin Qu, Xiao Zheng, Anqi Wang, Liang Li, Linjie Hu, Yu Zhang, Rong Su, Chao Niu, Sheng Zhang, Yanfang Qi, Jianxun Liu, Kefang Wang, Qihui Gao, George F |
author_facet |
Li, Shihua Yang, Ruirui Zhang, Di Han, Pu Xu, Zepeng Chen, Qian Zhao, Runchu Zhao, Xin Qu, Xiao Zheng, Anqi Wang, Liang Li, Linjie Hu, Yu Zhang, Rong Su, Chao Niu, Sheng Zhang, Yanfang Qi, Jianxun Liu, Kefang Wang, Qihui Gao, George F |
author_sort |
Li, Shihua |
title |
Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals |
title_short |
Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals |
title_full |
Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals |
title_fullStr |
Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals |
title_full_unstemmed |
Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals |
title_sort |
cross-species recognition and molecular basis of sars-cov-2 and sars-cov binding to ace2s of marine animals |
publisher |
Oxford University Press |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517163/ https://doi.org/10.1093/nsr/nwac122 |
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minke whale |
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minke whale |
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Natl Sci Rev |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517163/ http://dx.doi.org/10.1093/nsr/nwac122 |
op_rights |
© The Author(s) 2022. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/nsr/nwac122 |
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National Science Review |
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9 |
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9 |
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1766069727410520064 |