Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia
Currently, it is known that irisin can participate in the processes of thermoregulation and browning of adipose tissue, and, therefore, it is possible that it is involved in the microevolutionary mechanisms of adaptation to a cold. The aim of this study is to investigate the relationship between the...
Published in: | Genes |
---|---|
Main Authors: | , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
MDPI
2022
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498418/ https://doi.org/10.3390/genes13091612 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:9498418 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:9498418 2023-05-15T18:44:33+02:00 Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia Nikanorova, Alena A. Barashkov, Nikolay A. Pshennikova, Vera G. Gotovtsev, Nyurgun N. Romanov, Georgii P. Solovyev, Aisen V. Kuzmina, Sargylana S. Sazonov, Nikolay N. Fedorova, Sardana A. 2022-09-08 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498418/ https://doi.org/10.3390/genes13091612 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498418/ http://dx.doi.org/10.3390/genes13091612 © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY Genes (Basel) Article Text 2022 ftpubmed https://doi.org/10.3390/genes13091612 2022-09-25T01:19:37Z Currently, it is known that irisin can participate in the processes of thermoregulation and browning of adipose tissue, and, therefore, it is possible that it is involved in the microevolutionary mechanisms of adaptation to a cold. The aim of this study is to investigate the relationship between the uncoupling protein genes (UCP1, UCP2, UCP3) and the irisin levels in the residents of the coldest region of Siberia. The sample consisted of 279 Yakut people (185 females, 94 males, average age 19.8 ± 2.03 years). The females plasma irisin concentration was 8.33 ± 2.74 mcg/mL and the males was 7.76 ± 1.86 mcg/mL. Comparative analysis of irisin levels with the genotypes of six studied SNP-markers in females revealed a significant association of irisin with rs1800849-UCP3. The TT genotype of rs1800849 was associated with elevated levels of irisin (p = 0.01). It was also found that this TT genotype in females was associated with reduced weight and height (p = 0.03). We searched for natural selection signals for the T-allele rs1800849-UCP3; as a result of which, it was found that this allele has a significantly high frequency of distribution in northern (45%, CI: 0.42–0.484) compared with southern Asian populations (28%, CI: 0.244–0.316) (p = 0.01). The results obtained indicate the probable involvement of irisin and the UCP3 gene in thermoregulation, and the spread of its allelic variants is probably related to adaptation to a cold climate. Text Yakut Siberia PubMed Central (PMC) Browning ENVELOPE(164.050,164.050,-74.617,-74.617) Genes 13 9 1612 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Article |
spellingShingle |
Article Nikanorova, Alena A. Barashkov, Nikolay A. Pshennikova, Vera G. Gotovtsev, Nyurgun N. Romanov, Georgii P. Solovyev, Aisen V. Kuzmina, Sargylana S. Sazonov, Nikolay N. Fedorova, Sardana A. Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia |
topic_facet |
Article |
description |
Currently, it is known that irisin can participate in the processes of thermoregulation and browning of adipose tissue, and, therefore, it is possible that it is involved in the microevolutionary mechanisms of adaptation to a cold. The aim of this study is to investigate the relationship between the uncoupling protein genes (UCP1, UCP2, UCP3) and the irisin levels in the residents of the coldest region of Siberia. The sample consisted of 279 Yakut people (185 females, 94 males, average age 19.8 ± 2.03 years). The females plasma irisin concentration was 8.33 ± 2.74 mcg/mL and the males was 7.76 ± 1.86 mcg/mL. Comparative analysis of irisin levels with the genotypes of six studied SNP-markers in females revealed a significant association of irisin with rs1800849-UCP3. The TT genotype of rs1800849 was associated with elevated levels of irisin (p = 0.01). It was also found that this TT genotype in females was associated with reduced weight and height (p = 0.03). We searched for natural selection signals for the T-allele rs1800849-UCP3; as a result of which, it was found that this allele has a significantly high frequency of distribution in northern (45%, CI: 0.42–0.484) compared with southern Asian populations (28%, CI: 0.244–0.316) (p = 0.01). The results obtained indicate the probable involvement of irisin and the UCP3 gene in thermoregulation, and the spread of its allelic variants is probably related to adaptation to a cold climate. |
format |
Text |
author |
Nikanorova, Alena A. Barashkov, Nikolay A. Pshennikova, Vera G. Gotovtsev, Nyurgun N. Romanov, Georgii P. Solovyev, Aisen V. Kuzmina, Sargylana S. Sazonov, Nikolay N. Fedorova, Sardana A. |
author_facet |
Nikanorova, Alena A. Barashkov, Nikolay A. Pshennikova, Vera G. Gotovtsev, Nyurgun N. Romanov, Georgii P. Solovyev, Aisen V. Kuzmina, Sargylana S. Sazonov, Nikolay N. Fedorova, Sardana A. |
author_sort |
Nikanorova, Alena A. |
title |
Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia |
title_short |
Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia |
title_full |
Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia |
title_fullStr |
Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia |
title_full_unstemmed |
Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia |
title_sort |
relationships between uncoupling protein genes ucp1, ucp2 and ucp3 and irisin levels in residents of the coldest region of siberia |
publisher |
MDPI |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498418/ https://doi.org/10.3390/genes13091612 |
long_lat |
ENVELOPE(164.050,164.050,-74.617,-74.617) |
geographic |
Browning |
geographic_facet |
Browning |
genre |
Yakut Siberia |
genre_facet |
Yakut Siberia |
op_source |
Genes (Basel) |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498418/ http://dx.doi.org/10.3390/genes13091612 |
op_rights |
© 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/genes13091612 |
container_title |
Genes |
container_volume |
13 |
container_issue |
9 |
container_start_page |
1612 |
_version_ |
1766235239090225152 |