Multi-host dispersal of known and novel carnivore amdoparvoviruses
Amdoparvoviruses (family Parvoviridae) are ssDNA viruses that cause an immune complex-mediated wasting syndrome in carnivores. They are multi-host pathogens and cross-species infection is facilitated by the fact that viral entry is mediated by cellular Fc receptors recognizing antibody-coated viruse...
Published in: | Virus Evolution |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
Oxford University Press
2020
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492287/ https://doi.org/10.1093/ve/veaa072 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:9492287 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:9492287 2023-05-15T15:15:35+02:00 Multi-host dispersal of known and novel carnivore amdoparvoviruses Canuti, Marta McDonald, Emily Graham, Stephanie M Rodrigues, Bruce Bouchard, Émilie Neville, Richard Pitcher, Mac Whitney, Hugh G Marshall, H Dawn Lang, Andrew S 2020-12-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492287/ https://doi.org/10.1093/ve/veaa072 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492287/ http://dx.doi.org/10.1093/ve/veaa072 © The Author(s) 2020. Published by Oxford University Press. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com CC-BY-NC Virus Evol Research Article Text 2020 ftpubmed https://doi.org/10.1093/ve/veaa072 2022-09-25T01:06:16Z Amdoparvoviruses (family Parvoviridae) are ssDNA viruses that cause an immune complex-mediated wasting syndrome in carnivores. They are multi-host pathogens and cross-species infection is facilitated by the fact that viral entry is mediated by cellular Fc receptors recognizing antibody-coated viruses. We developed a pan-amdoparvovirus PCR and screened tissue samples from 666 wild carnivores (families Felidae, Canidae, and Mustelidae) from Newfoundland or Labrador (Canada) and molecularly characterized the identified strains. Fifty-four out of 666 (8.1%) animals were amdoparvovirus-positive. Infection rate was the highest in American mink (34/47, 72.3%), followed by foxes (Arctic and red foxes, 13/311, 4.2%), lynx (2/58, 3.5%), and American martens (5/156, 3.4%). No virus was detected in samples from 87 coyotes and 17 ermines. Viruses from Newfoundland were classified as Aleutian mink disease virus (AMDV). Mink harvested near AMDV-affected fur farms had higher prevalence (24/24, 100%) than other mink (10/23, 43.5%; P < 0.001) and their viruses were phylogenetically closely related to those from farms, while most viruses from other mink were in other clades. Strains from three foxes and two lynx were highly related to mink strains. This proves that farms disperse AMDV that subsequently spreads among wild mink (maintenance host) and transmits to other spillover carnivore hosts. In Labrador two novel viruses were identified, Labrador amdoparvovirus 1 (LaAV-1) found in foxes (9/261, 3.5%) and martens (5/156, 3.4%), and LaAV-2 found in one fox (0.4%). LaAV-1 fulfills all requirements to be classified as a novel species. LaAV-1 was most similar to viruses of mink and skunks (AMDV and skunk amdoparvovirus (SKAV)) while LaAV-2 was more closely related to other viruses infecting canids. LaAV-1 capsid proteins were almost indistinguishable from those of AMDV in some regions, suggesting that LaAV-1 could be a virus of mustelids that can infect foxes. While intensive farming practices provide occasions for inter-species ... Text Arctic Newfoundland Lynx PubMed Central (PMC) Arctic Canada Newfoundland Virus Evolution 6 2 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Research Article |
spellingShingle |
Research Article Canuti, Marta McDonald, Emily Graham, Stephanie M Rodrigues, Bruce Bouchard, Émilie Neville, Richard Pitcher, Mac Whitney, Hugh G Marshall, H Dawn Lang, Andrew S Multi-host dispersal of known and novel carnivore amdoparvoviruses |
topic_facet |
Research Article |
description |
Amdoparvoviruses (family Parvoviridae) are ssDNA viruses that cause an immune complex-mediated wasting syndrome in carnivores. They are multi-host pathogens and cross-species infection is facilitated by the fact that viral entry is mediated by cellular Fc receptors recognizing antibody-coated viruses. We developed a pan-amdoparvovirus PCR and screened tissue samples from 666 wild carnivores (families Felidae, Canidae, and Mustelidae) from Newfoundland or Labrador (Canada) and molecularly characterized the identified strains. Fifty-four out of 666 (8.1%) animals were amdoparvovirus-positive. Infection rate was the highest in American mink (34/47, 72.3%), followed by foxes (Arctic and red foxes, 13/311, 4.2%), lynx (2/58, 3.5%), and American martens (5/156, 3.4%). No virus was detected in samples from 87 coyotes and 17 ermines. Viruses from Newfoundland were classified as Aleutian mink disease virus (AMDV). Mink harvested near AMDV-affected fur farms had higher prevalence (24/24, 100%) than other mink (10/23, 43.5%; P < 0.001) and their viruses were phylogenetically closely related to those from farms, while most viruses from other mink were in other clades. Strains from three foxes and two lynx were highly related to mink strains. This proves that farms disperse AMDV that subsequently spreads among wild mink (maintenance host) and transmits to other spillover carnivore hosts. In Labrador two novel viruses were identified, Labrador amdoparvovirus 1 (LaAV-1) found in foxes (9/261, 3.5%) and martens (5/156, 3.4%), and LaAV-2 found in one fox (0.4%). LaAV-1 fulfills all requirements to be classified as a novel species. LaAV-1 was most similar to viruses of mink and skunks (AMDV and skunk amdoparvovirus (SKAV)) while LaAV-2 was more closely related to other viruses infecting canids. LaAV-1 capsid proteins were almost indistinguishable from those of AMDV in some regions, suggesting that LaAV-1 could be a virus of mustelids that can infect foxes. While intensive farming practices provide occasions for inter-species ... |
format |
Text |
author |
Canuti, Marta McDonald, Emily Graham, Stephanie M Rodrigues, Bruce Bouchard, Émilie Neville, Richard Pitcher, Mac Whitney, Hugh G Marshall, H Dawn Lang, Andrew S |
author_facet |
Canuti, Marta McDonald, Emily Graham, Stephanie M Rodrigues, Bruce Bouchard, Émilie Neville, Richard Pitcher, Mac Whitney, Hugh G Marshall, H Dawn Lang, Andrew S |
author_sort |
Canuti, Marta |
title |
Multi-host dispersal of known and novel carnivore amdoparvoviruses |
title_short |
Multi-host dispersal of known and novel carnivore amdoparvoviruses |
title_full |
Multi-host dispersal of known and novel carnivore amdoparvoviruses |
title_fullStr |
Multi-host dispersal of known and novel carnivore amdoparvoviruses |
title_full_unstemmed |
Multi-host dispersal of known and novel carnivore amdoparvoviruses |
title_sort |
multi-host dispersal of known and novel carnivore amdoparvoviruses |
publisher |
Oxford University Press |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492287/ https://doi.org/10.1093/ve/veaa072 |
geographic |
Arctic Canada Newfoundland |
geographic_facet |
Arctic Canada Newfoundland |
genre |
Arctic Newfoundland Lynx |
genre_facet |
Arctic Newfoundland Lynx |
op_source |
Virus Evol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492287/ http://dx.doi.org/10.1093/ve/veaa072 |
op_rights |
© The Author(s) 2020. Published by Oxford University Press. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1093/ve/veaa072 |
container_title |
Virus Evolution |
container_volume |
6 |
container_issue |
2 |
_version_ |
1766345949805805568 |