Semi-quantitative Assessment of Alzheimer’s-like Pathology in Two Aged Polar Bears (Ursus maritimus)
Age-associated neurodegenerative changes, including amyloid β (Aβ) plaques, neurofibrillary tangles (NFTs), and amyloid angiopathy comparable to those seen in the brains of human patients with Alzheimer’s disease (AD), have been reported in the brains of aged bears. However, the significance of thes...
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2022
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413527/ http://www.ncbi.nlm.nih.gov/pubmed/35882509 https://doi.org/10.30802/AALAS-CM-22-000036 |
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ftpubmed:oai:pubmedcentral.nih.gov:9413527 2023-05-15T18:42:24+02:00 Semi-quantitative Assessment of Alzheimer’s-like Pathology in Two Aged Polar Bears (Ursus maritimus) Lucot, Katherine L Bukhari, Syed A Webber, Ebony D Bonham, T Adam Darian-Smith, Corinna Montine, Thomas J Green, Sherril L 2022-08 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413527/ http://www.ncbi.nlm.nih.gov/pubmed/35882509 https://doi.org/10.30802/AALAS-CM-22-000036 en eng American Association for Laboratory Animal Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413527/ http://www.ncbi.nlm.nih.gov/pubmed/35882509 http://dx.doi.org/10.30802/AALAS-CM-22-000036 © American Association for Laboratory Animal Science Comp Med Case Study Text 2022 ftpubmed https://doi.org/10.30802/AALAS-CM-22-000036 2023-02-05T01:43:10Z Age-associated neurodegenerative changes, including amyloid β (Aβ) plaques, neurofibrillary tangles (NFTs), and amyloid angiopathy comparable to those seen in the brains of human patients with Alzheimer’s disease (AD), have been reported in the brains of aged bears. However, the significance of these findings in bears is unclear due to the difficulty in assessing cognitive impairment and the lack of standardized approaches for the semiquantitative evaluation of Aβ plaques and NFTs. In this study, we evaluate the neuropathologic changes in archival brain tissue of 2 aged polar bears (Ursus maritimus, ages 28 and 37) using the National Institute of Aging-Alzheimer Association (NIA-AA) consensus guidelines for the neuropathologic assessment of Alzheimer’s Disease (AD). Both bears had an Aβ (A) score of 3 of 3, Braak stage (B score) of 2 of 3, and neuritic plaque (C) score of 3 of 3. These findings are consistent with the neurodegenerative changes observed in brains of patients with AD. The application of NIA-AA consensus guidelines, as applied to the neuropathologic assessment of the aged bears in this report, demonstrates the use of standardized semiquantitative assessment systems for comparative, translational studies of aging in a vulnerable wildlife species. Text Ursus maritimus PubMed Central (PMC) Comparative Medicine 72 4 267 272 |
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Case Study Lucot, Katherine L Bukhari, Syed A Webber, Ebony D Bonham, T Adam Darian-Smith, Corinna Montine, Thomas J Green, Sherril L Semi-quantitative Assessment of Alzheimer’s-like Pathology in Two Aged Polar Bears (Ursus maritimus) |
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Case Study |
description |
Age-associated neurodegenerative changes, including amyloid β (Aβ) plaques, neurofibrillary tangles (NFTs), and amyloid angiopathy comparable to those seen in the brains of human patients with Alzheimer’s disease (AD), have been reported in the brains of aged bears. However, the significance of these findings in bears is unclear due to the difficulty in assessing cognitive impairment and the lack of standardized approaches for the semiquantitative evaluation of Aβ plaques and NFTs. In this study, we evaluate the neuropathologic changes in archival brain tissue of 2 aged polar bears (Ursus maritimus, ages 28 and 37) using the National Institute of Aging-Alzheimer Association (NIA-AA) consensus guidelines for the neuropathologic assessment of Alzheimer’s Disease (AD). Both bears had an Aβ (A) score of 3 of 3, Braak stage (B score) of 2 of 3, and neuritic plaque (C) score of 3 of 3. These findings are consistent with the neurodegenerative changes observed in brains of patients with AD. The application of NIA-AA consensus guidelines, as applied to the neuropathologic assessment of the aged bears in this report, demonstrates the use of standardized semiquantitative assessment systems for comparative, translational studies of aging in a vulnerable wildlife species. |
format |
Text |
author |
Lucot, Katherine L Bukhari, Syed A Webber, Ebony D Bonham, T Adam Darian-Smith, Corinna Montine, Thomas J Green, Sherril L |
author_facet |
Lucot, Katherine L Bukhari, Syed A Webber, Ebony D Bonham, T Adam Darian-Smith, Corinna Montine, Thomas J Green, Sherril L |
author_sort |
Lucot, Katherine L |
title |
Semi-quantitative Assessment of Alzheimer’s-like Pathology in Two Aged Polar Bears (Ursus maritimus) |
title_short |
Semi-quantitative Assessment of Alzheimer’s-like Pathology in Two Aged Polar Bears (Ursus maritimus) |
title_full |
Semi-quantitative Assessment of Alzheimer’s-like Pathology in Two Aged Polar Bears (Ursus maritimus) |
title_fullStr |
Semi-quantitative Assessment of Alzheimer’s-like Pathology in Two Aged Polar Bears (Ursus maritimus) |
title_full_unstemmed |
Semi-quantitative Assessment of Alzheimer’s-like Pathology in Two Aged Polar Bears (Ursus maritimus) |
title_sort |
semi-quantitative assessment of alzheimer’s-like pathology in two aged polar bears (ursus maritimus) |
publisher |
American Association for Laboratory Animal Science |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413527/ http://www.ncbi.nlm.nih.gov/pubmed/35882509 https://doi.org/10.30802/AALAS-CM-22-000036 |
genre |
Ursus maritimus |
genre_facet |
Ursus maritimus |
op_source |
Comp Med |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413527/ http://www.ncbi.nlm.nih.gov/pubmed/35882509 http://dx.doi.org/10.30802/AALAS-CM-22-000036 |
op_rights |
© American Association for Laboratory Animal Science |
op_doi |
https://doi.org/10.30802/AALAS-CM-22-000036 |
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Comparative Medicine |
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72 |
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4 |
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267 |
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272 |
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