Salmon fish protein supplement increases serum vitamin B12 and selenium concentrations: secondary analysis of a randomised controlled trial
PURPOSE: The main aim of the present study was to examine the effect of a fish protein supplement made from by-products from production of Atlantic salmon, on blood concentration of micronutrients. METHODS: We conducted an 8-week double-blind parallel-group randomised controlled trial. In total, 88...
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2022
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ftpubmed:oai:pubmedcentral.nih.gov:9363293 2023-05-15T15:32:39+02:00 Salmon fish protein supplement increases serum vitamin B12 and selenium concentrations: secondary analysis of a randomised controlled trial Hustad, Kristin S. Ottestad, Inger Olsen, Thomas Sæther, Thomas Ulven, Stine M. Holven, Kirsten B. 2022-04-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363293/ http://www.ncbi.nlm.nih.gov/pubmed/35362766 https://doi.org/10.1007/s00394-022-02857-4 en eng Springer Berlin Heidelberg http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363293/ http://www.ncbi.nlm.nih.gov/pubmed/35362766 http://dx.doi.org/10.1007/s00394-022-02857-4 © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . CC-BY Eur J Nutr Original Contribution Text 2022 ftpubmed https://doi.org/10.1007/s00394-022-02857-4 2022-08-14T00:53:33Z PURPOSE: The main aim of the present study was to examine the effect of a fish protein supplement made from by-products from production of Atlantic salmon, on blood concentration of micronutrients. METHODS: We conducted an 8-week double-blind parallel-group randomised controlled trial. In total, 88 adults were randomised to a salmon fish protein supplement or placebo, and 74 participants were included in the analysis of vitamin D, omega-3, vitamin B12, selenium, folate, zinc, homocysteine and mercury. RESULTS: During the intervention period, geometric mean (GSD) of serum vitamin B12 concentrations increased from 304 (1.40) to 359 (1.42) pmol/L in the fish protein group (P vs. controls = 0.004) and mean (SD) serum selenium increased from 1.18 (0.22) to 1.30 (0.20) μmol/L (P vs. controls = 0.002). The prevalence of low vitamin B12 status (B12 < 148–221 > pmol/L) decreased from 15.4 to 2.6% in the fish protein group, while increasing from 5.9 to 17.6% in the placebo group (P = 0.045). There was no difference between the groups in serum levels of the other micronutrients measured. CONCLUSION: Including a salmon fish protein supplement in the daily diet for 8 weeks, increases serum vitamin B12 and selenium concentrations. From a sustainability perspective, by-products with high contents of micronutrients and low contents of contaminants, could be a valuable dietary supplement or food ingredient in populations with suboptimal intake. TRAIL REGISTRATION: The study was registered at ClinicalTrials.gov (ID: NCT03764423) on June 29th 2018. Text Atlantic salmon PubMed Central (PMC) European Journal of Nutrition 61 6 3085 3093 |
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Original Contribution Hustad, Kristin S. Ottestad, Inger Olsen, Thomas Sæther, Thomas Ulven, Stine M. Holven, Kirsten B. Salmon fish protein supplement increases serum vitamin B12 and selenium concentrations: secondary analysis of a randomised controlled trial |
topic_facet |
Original Contribution |
description |
PURPOSE: The main aim of the present study was to examine the effect of a fish protein supplement made from by-products from production of Atlantic salmon, on blood concentration of micronutrients. METHODS: We conducted an 8-week double-blind parallel-group randomised controlled trial. In total, 88 adults were randomised to a salmon fish protein supplement or placebo, and 74 participants were included in the analysis of vitamin D, omega-3, vitamin B12, selenium, folate, zinc, homocysteine and mercury. RESULTS: During the intervention period, geometric mean (GSD) of serum vitamin B12 concentrations increased from 304 (1.40) to 359 (1.42) pmol/L in the fish protein group (P vs. controls = 0.004) and mean (SD) serum selenium increased from 1.18 (0.22) to 1.30 (0.20) μmol/L (P vs. controls = 0.002). The prevalence of low vitamin B12 status (B12 < 148–221 > pmol/L) decreased from 15.4 to 2.6% in the fish protein group, while increasing from 5.9 to 17.6% in the placebo group (P = 0.045). There was no difference between the groups in serum levels of the other micronutrients measured. CONCLUSION: Including a salmon fish protein supplement in the daily diet for 8 weeks, increases serum vitamin B12 and selenium concentrations. From a sustainability perspective, by-products with high contents of micronutrients and low contents of contaminants, could be a valuable dietary supplement or food ingredient in populations with suboptimal intake. TRAIL REGISTRATION: The study was registered at ClinicalTrials.gov (ID: NCT03764423) on June 29th 2018. |
format |
Text |
author |
Hustad, Kristin S. Ottestad, Inger Olsen, Thomas Sæther, Thomas Ulven, Stine M. Holven, Kirsten B. |
author_facet |
Hustad, Kristin S. Ottestad, Inger Olsen, Thomas Sæther, Thomas Ulven, Stine M. Holven, Kirsten B. |
author_sort |
Hustad, Kristin S. |
title |
Salmon fish protein supplement increases serum vitamin B12 and selenium concentrations: secondary analysis of a randomised controlled trial |
title_short |
Salmon fish protein supplement increases serum vitamin B12 and selenium concentrations: secondary analysis of a randomised controlled trial |
title_full |
Salmon fish protein supplement increases serum vitamin B12 and selenium concentrations: secondary analysis of a randomised controlled trial |
title_fullStr |
Salmon fish protein supplement increases serum vitamin B12 and selenium concentrations: secondary analysis of a randomised controlled trial |
title_full_unstemmed |
Salmon fish protein supplement increases serum vitamin B12 and selenium concentrations: secondary analysis of a randomised controlled trial |
title_sort |
salmon fish protein supplement increases serum vitamin b12 and selenium concentrations: secondary analysis of a randomised controlled trial |
publisher |
Springer Berlin Heidelberg |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363293/ http://www.ncbi.nlm.nih.gov/pubmed/35362766 https://doi.org/10.1007/s00394-022-02857-4 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Eur J Nutr |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363293/ http://www.ncbi.nlm.nih.gov/pubmed/35362766 http://dx.doi.org/10.1007/s00394-022-02857-4 |
op_rights |
© The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s00394-022-02857-4 |
container_title |
European Journal of Nutrition |
container_volume |
61 |
container_issue |
6 |
container_start_page |
3085 |
op_container_end_page |
3093 |
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1766363139726639104 |