Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements
Antibiotic resistance genes (ARGs) are undergoing a remarkably rapid geographic expansion in various ecosystems, including pristine environments such as Antarctica. The study of ARGs and environmental resistance genes (ERGs) mechanisms could provide a better understanding of their origin, evolution,...
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ftpubmed:oai:pubmedcentral.nih.gov:9320737 2023-05-15T13:30:32+02:00 Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements Santos, Andrés Burgos, Felipe Martinez-Urtaza, Jaime Barrientos, Leticia 2022-07-15 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320737/ http://www.ncbi.nlm.nih.gov/pubmed/35889151 https://doi.org/10.3390/microorganisms10071432 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320737/ http://www.ncbi.nlm.nih.gov/pubmed/35889151 http://dx.doi.org/10.3390/microorganisms10071432 © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY Microorganisms Brief Report Text 2022 ftpubmed https://doi.org/10.3390/microorganisms10071432 2022-07-31T03:11:21Z Antibiotic resistance genes (ARGs) are undergoing a remarkably rapid geographic expansion in various ecosystems, including pristine environments such as Antarctica. The study of ARGs and environmental resistance genes (ERGs) mechanisms could provide a better understanding of their origin, evolution, and dissemination in these pristine environments. Here, we describe the diversity of ARGs and ERGs and the importance of mobile genetic elements as a possible mechanism for the dissemination of resistance genes in Antarctica. We analyzed five soil metagenomes from Deception Island in Antarctica. Results showed that detected ARGs are associated with mechanisms such as antibiotic efflux, antibiotic inactivation, and target alteration. On the other hand, resistance to metals, surfactants, and aromatic hydrocarbons were the dominant ERGs. The taxonomy of ARGs showed that Pseudomonas, Psychrobacter, and Staphylococcus could be key taxa for studying antibiotic resistance and environmental resistance to stress in Deception Island. In addition, results showed that ARGs are mainly associated with phage-type mobile elements suggesting a potential role in their dissemination and prevalence. Finally, these results provide valuable information regarding the ARGs and ERGs in Deception Island including the potential contribution of mobile genetic elements to the spread of ARGs and ERGs in one of the least studied Antarctic ecosystems to date. Text Antarc* Antarctic Antarctica Deception Island PubMed Central (PMC) Antarctic Deception Island ENVELOPE(-60.633,-60.633,-62.950,-62.950) Microorganisms 10 7 1432 |
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Brief Report Santos, Andrés Burgos, Felipe Martinez-Urtaza, Jaime Barrientos, Leticia Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements |
topic_facet |
Brief Report |
description |
Antibiotic resistance genes (ARGs) are undergoing a remarkably rapid geographic expansion in various ecosystems, including pristine environments such as Antarctica. The study of ARGs and environmental resistance genes (ERGs) mechanisms could provide a better understanding of their origin, evolution, and dissemination in these pristine environments. Here, we describe the diversity of ARGs and ERGs and the importance of mobile genetic elements as a possible mechanism for the dissemination of resistance genes in Antarctica. We analyzed five soil metagenomes from Deception Island in Antarctica. Results showed that detected ARGs are associated with mechanisms such as antibiotic efflux, antibiotic inactivation, and target alteration. On the other hand, resistance to metals, surfactants, and aromatic hydrocarbons were the dominant ERGs. The taxonomy of ARGs showed that Pseudomonas, Psychrobacter, and Staphylococcus could be key taxa for studying antibiotic resistance and environmental resistance to stress in Deception Island. In addition, results showed that ARGs are mainly associated with phage-type mobile elements suggesting a potential role in their dissemination and prevalence. Finally, these results provide valuable information regarding the ARGs and ERGs in Deception Island including the potential contribution of mobile genetic elements to the spread of ARGs and ERGs in one of the least studied Antarctic ecosystems to date. |
format |
Text |
author |
Santos, Andrés Burgos, Felipe Martinez-Urtaza, Jaime Barrientos, Leticia |
author_facet |
Santos, Andrés Burgos, Felipe Martinez-Urtaza, Jaime Barrientos, Leticia |
author_sort |
Santos, Andrés |
title |
Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements |
title_short |
Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements |
title_full |
Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements |
title_fullStr |
Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements |
title_full_unstemmed |
Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements |
title_sort |
metagenomic characterization of resistance genes in deception island and their association with mobile genetic elements |
publisher |
MDPI |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320737/ http://www.ncbi.nlm.nih.gov/pubmed/35889151 https://doi.org/10.3390/microorganisms10071432 |
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ENVELOPE(-60.633,-60.633,-62.950,-62.950) |
geographic |
Antarctic Deception Island |
geographic_facet |
Antarctic Deception Island |
genre |
Antarc* Antarctic Antarctica Deception Island |
genre_facet |
Antarc* Antarctic Antarctica Deception Island |
op_source |
Microorganisms |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320737/ http://www.ncbi.nlm.nih.gov/pubmed/35889151 http://dx.doi.org/10.3390/microorganisms10071432 |
op_rights |
© 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
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https://doi.org/10.3390/microorganisms10071432 |
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Microorganisms |
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10 |
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7 |
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1432 |
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1766009698418425856 |