Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet
The impact of a gluten-free diet (GFD) on screen-detected celiac disease (CD) is currently ambiguous. We aimed to identify the population-based prevalence of undiagnosed adult CD and examine the impact of a GFD on screen-detected CD. In total, 12,981 adults participated in a population-based health...
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ftpubmed:oai:pubmedcentral.nih.gov:9314380 2023-05-15T18:34:41+02:00 Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet Kvamme, Jan-Magnus Sørbye, Sveinung Florholmen, Jon Halstensen, Trond S. 2022-07-25 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314380/ http://www.ncbi.nlm.nih.gov/pubmed/35879335 https://doi.org/10.1038/s41598-022-16705-2 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314380/ http://www.ncbi.nlm.nih.gov/pubmed/35879335 http://dx.doi.org/10.1038/s41598-022-16705-2 © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . CC-BY Sci Rep Article Text 2022 ftpubmed https://doi.org/10.1038/s41598-022-16705-2 2022-07-31T02:54:32Z The impact of a gluten-free diet (GFD) on screen-detected celiac disease (CD) is currently ambiguous. We aimed to identify the population-based prevalence of undiagnosed adult CD and examine the impact of a GFD on screen-detected CD. In total, 12,981 adults participated in a population-based health study in Tromsø, Norway. Participants with increased levels of anti-tissue transglutaminase-2 IgA or anti-deamidated gliadin peptide IgG were invited to undergo gastroduodenoscopy with both histological and immunohistochemical examination of small-bowel biopsies. The prevalence of previously diagnosed CD was 0.37%. Additionally, the prevalence of previously undiagnosed CD was 1.10%. Thus, 1.47% of the population had CD, of whom 75% were previously undiagnosed. A GFD resulted in significant improvements in overall gastrointestinal symptoms, diarrhea, and health-related quality of life, with reduced abdominal discomfort (76%) and improved levels of energy (58%). The large majority of patients with adult CD were undiagnosed and benefited from a GFD with reduced gastrointestinal symptoms and improved health-related quality of life. In clinical practice, there should be a low threshold for CD testing even in the absence of abdominal complaints because most adult patients appear to consider their symptoms a part of their normal state and therefore remain untested and undiagnosed. Trial registration: Clinical Trials. Gov Identifier: NCT01695681. Text Tromsø PubMed Central (PMC) Norway Tromsø Scientific Reports 12 1 |
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Article Kvamme, Jan-Magnus Sørbye, Sveinung Florholmen, Jon Halstensen, Trond S. Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet |
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description |
The impact of a gluten-free diet (GFD) on screen-detected celiac disease (CD) is currently ambiguous. We aimed to identify the population-based prevalence of undiagnosed adult CD and examine the impact of a GFD on screen-detected CD. In total, 12,981 adults participated in a population-based health study in Tromsø, Norway. Participants with increased levels of anti-tissue transglutaminase-2 IgA or anti-deamidated gliadin peptide IgG were invited to undergo gastroduodenoscopy with both histological and immunohistochemical examination of small-bowel biopsies. The prevalence of previously diagnosed CD was 0.37%. Additionally, the prevalence of previously undiagnosed CD was 1.10%. Thus, 1.47% of the population had CD, of whom 75% were previously undiagnosed. A GFD resulted in significant improvements in overall gastrointestinal symptoms, diarrhea, and health-related quality of life, with reduced abdominal discomfort (76%) and improved levels of energy (58%). The large majority of patients with adult CD were undiagnosed and benefited from a GFD with reduced gastrointestinal symptoms and improved health-related quality of life. In clinical practice, there should be a low threshold for CD testing even in the absence of abdominal complaints because most adult patients appear to consider their symptoms a part of their normal state and therefore remain untested and undiagnosed. Trial registration: Clinical Trials. Gov Identifier: NCT01695681. |
format |
Text |
author |
Kvamme, Jan-Magnus Sørbye, Sveinung Florholmen, Jon Halstensen, Trond S. |
author_facet |
Kvamme, Jan-Magnus Sørbye, Sveinung Florholmen, Jon Halstensen, Trond S. |
author_sort |
Kvamme, Jan-Magnus |
title |
Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet |
title_short |
Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet |
title_full |
Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet |
title_fullStr |
Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet |
title_full_unstemmed |
Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet |
title_sort |
population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet |
publisher |
Nature Publishing Group UK |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314380/ http://www.ncbi.nlm.nih.gov/pubmed/35879335 https://doi.org/10.1038/s41598-022-16705-2 |
geographic |
Norway Tromsø |
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Norway Tromsø |
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Tromsø |
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Tromsø |
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Sci Rep |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314380/ http://www.ncbi.nlm.nih.gov/pubmed/35879335 http://dx.doi.org/10.1038/s41598-022-16705-2 |
op_rights |
© The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
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CC-BY |
op_doi |
https://doi.org/10.1038/s41598-022-16705-2 |
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