Association Between Dietary Nitrite intake and Glioma Risk: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies
BACKGROUND: Nitrite and nitrate intake through food and water may be an important risk factor for many cancers, including glioma. However, the association of nitrite and nitrate with glioma is unclear. OBJECTIVE: This review aimed to quantitatively assess the effects of nitrite and nitrate on glioma...
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ftpubmed:oai:pubmedcentral.nih.gov:9304866 2023-05-15T16:29:57+02:00 Association Between Dietary Nitrite intake and Glioma Risk: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies Zhang, Weichunbai Jiang, Jing He, Yongqi Li, Xinyi Yin, Shuo Chen, Feng Li, Wenbin 2022-07-08 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304866/ http://www.ncbi.nlm.nih.gov/pubmed/35875114 https://doi.org/10.3389/fonc.2022.910476 en eng Frontiers Media S.A. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304866/ http://www.ncbi.nlm.nih.gov/pubmed/35875114 http://dx.doi.org/10.3389/fonc.2022.910476 Copyright © 2022 Zhang, Jiang, He, Li, Yin, Chen and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. CC-BY Front Oncol Oncology Text 2022 ftpubmed https://doi.org/10.3389/fonc.2022.910476 2022-07-31T02:33:37Z BACKGROUND: Nitrite and nitrate intake through food and water may be an important risk factor for many cancers, including glioma. However, the association of nitrite and nitrate with glioma is unclear. OBJECTIVE: This review aimed to quantitatively assess the effects of nitrite and nitrate on glioma by meta-analysis. METHODS: A literature search was conducted for available articles published in English using the databases of Embase, Web of Science, PubMed, Medline, and the Cochrane Library up to 24 March 2022. According to heterogeneity, the fixed-effects or random-effects model was selected to obtain the merger’s relative risk (RR). Based on the methods described by Greenland and Longnecker, we explored the dose-response relationship between nitrite/nitrate and the risk of glioma. Subgroup analysis, sensitivity analysis, and publication bias tests were also used. RESULTS: This study reviewed 17 articles, including 812,107 participants and 4,574 cases. For glioma in adults, compared with the lowest intakes, the highest intakes of nitrite significantly increased the risk of glioma (RR=1.26, 95% confidence interval (95%CI):1.09-1.47). For brain tumors in children, compared with the lowest intakes, the highest intakes of nitrate significantly increased the risk of brain tumors (RR=1.27, 95%CI:1.06-1.52). The results of subgroup and sensitivity analyses remained unchanged. In the dose-response relationship, per 1 mg/day increase in nitrite intake increased the risk of glioma by 14% (RR=1.14, 95%CI:1.01-1.27). CONCLUSIONS: Our analysis suggests that nitrite increases the risk of glioma in adults, while nitrate increases the risk of brain tumors in children. Therefore, the effects of nitrite and nitrate on glioma cannot be ignored. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/, identifier CRD42022320295. Text Greenland PubMed Central (PMC) Greenland Frontiers in Oncology 12 |
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Oncology |
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Oncology Zhang, Weichunbai Jiang, Jing He, Yongqi Li, Xinyi Yin, Shuo Chen, Feng Li, Wenbin Association Between Dietary Nitrite intake and Glioma Risk: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies |
topic_facet |
Oncology |
description |
BACKGROUND: Nitrite and nitrate intake through food and water may be an important risk factor for many cancers, including glioma. However, the association of nitrite and nitrate with glioma is unclear. OBJECTIVE: This review aimed to quantitatively assess the effects of nitrite and nitrate on glioma by meta-analysis. METHODS: A literature search was conducted for available articles published in English using the databases of Embase, Web of Science, PubMed, Medline, and the Cochrane Library up to 24 March 2022. According to heterogeneity, the fixed-effects or random-effects model was selected to obtain the merger’s relative risk (RR). Based on the methods described by Greenland and Longnecker, we explored the dose-response relationship between nitrite/nitrate and the risk of glioma. Subgroup analysis, sensitivity analysis, and publication bias tests were also used. RESULTS: This study reviewed 17 articles, including 812,107 participants and 4,574 cases. For glioma in adults, compared with the lowest intakes, the highest intakes of nitrite significantly increased the risk of glioma (RR=1.26, 95% confidence interval (95%CI):1.09-1.47). For brain tumors in children, compared with the lowest intakes, the highest intakes of nitrate significantly increased the risk of brain tumors (RR=1.27, 95%CI:1.06-1.52). The results of subgroup and sensitivity analyses remained unchanged. In the dose-response relationship, per 1 mg/day increase in nitrite intake increased the risk of glioma by 14% (RR=1.14, 95%CI:1.01-1.27). CONCLUSIONS: Our analysis suggests that nitrite increases the risk of glioma in adults, while nitrate increases the risk of brain tumors in children. Therefore, the effects of nitrite and nitrate on glioma cannot be ignored. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/, identifier CRD42022320295. |
format |
Text |
author |
Zhang, Weichunbai Jiang, Jing He, Yongqi Li, Xinyi Yin, Shuo Chen, Feng Li, Wenbin |
author_facet |
Zhang, Weichunbai Jiang, Jing He, Yongqi Li, Xinyi Yin, Shuo Chen, Feng Li, Wenbin |
author_sort |
Zhang, Weichunbai |
title |
Association Between Dietary Nitrite intake and Glioma Risk: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies |
title_short |
Association Between Dietary Nitrite intake and Glioma Risk: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies |
title_full |
Association Between Dietary Nitrite intake and Glioma Risk: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies |
title_fullStr |
Association Between Dietary Nitrite intake and Glioma Risk: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies |
title_full_unstemmed |
Association Between Dietary Nitrite intake and Glioma Risk: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies |
title_sort |
association between dietary nitrite intake and glioma risk: a systematic review and dose-response meta-analysis of observational studies |
publisher |
Frontiers Media S.A. |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304866/ http://www.ncbi.nlm.nih.gov/pubmed/35875114 https://doi.org/10.3389/fonc.2022.910476 |
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Greenland |
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Greenland |
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Greenland |
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Greenland |
op_source |
Front Oncol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304866/ http://www.ncbi.nlm.nih.gov/pubmed/35875114 http://dx.doi.org/10.3389/fonc.2022.910476 |
op_rights |
Copyright © 2022 Zhang, Jiang, He, Li, Yin, Chen and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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CC-BY |
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https://doi.org/10.3389/fonc.2022.910476 |
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Frontiers in Oncology |
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12 |
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