Altered plasma cytokines in dogs with atopic dermatitis
BACKGROUND: Canine (Canis lupus familiaris) atopic dermatitis (AD) shares similar clinical signs to human AD. The abnormal immune response of AD is orchestrated by T lymphocytes, and may include variable involvement of cytokines, regulatory T (Treg) cells, eosinophils, mast cells and other immune co...
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ftpubmed:oai:pubmedcentral.nih.gov:9299684 2023-05-15T15:50:49+02:00 Altered plasma cytokines in dogs with atopic dermatitis Mazrier, Hamutal Vogelnest, Linda J. Taylor, Rosanne M. Williamson, Peter 2021-11-24 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299684/ http://www.ncbi.nlm.nih.gov/pubmed/34817106 https://doi.org/10.1111/vde.13044 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299684/ http://www.ncbi.nlm.nih.gov/pubmed/34817106 http://dx.doi.org/10.1111/vde.13044 © 2021 The Authors. Veterinary Dermatology published by John Wiley & Sons Ltd on behalf of ESVD and ACVD https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. CC-BY-NC-ND Vet Dermatol Hypersensitivity Disorders Text 2021 ftpubmed https://doi.org/10.1111/vde.13044 2022-07-31T02:20:05Z BACKGROUND: Canine (Canis lupus familiaris) atopic dermatitis (AD) shares similar clinical signs to human AD. The abnormal immune response of AD is orchestrated by T lymphocytes, and may include variable involvement of cytokines, regulatory T (Treg) cells, eosinophils, mast cells and other immune components. Helper T (Th)2 cytokines often predominate initially, followed by Th1 cytokines in more chronic phases. HYPOTHESIS/OBJECTIVES: Pro‐inflammatory and Treg cytokines have been shown to play a role in human AD, yet their importance is not clear in canine AD. Hence, this study aimed to measure the concentrations of cytokines/chemokines not traditionally associated with Th1/Th2 response. ANIMALS: Canine AD patients (n = 27), compared to control dogs (n = 11). METHODS AND MATERIALS: A total of 19 plasma cytokines were assayed using canine specific multiplex immuno‐assays. RESULTS: The plasma concentrations of CXC Motif Chemokine Ligand 8 (CXCL8), interleukin (IL)‐7 and IL‐15 cytokines were elevated in canine AD patients, compared to control dogs. In addition, stem‐cell factor (SCF) concentrations were reduced in the plasma of canine AD patients compared to control dogs. Distinct cytokine profiles were found in dogs belonging to the Staffordshire breeds, a group with increased risk of AD. In particular, granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) had significantly elevated concentrations. CONCLUSIONS AND CLINICAL RELEVANCE: Some of the plasma cytokine alterations in canine AD described here, particularly of IL‐7, have not been reported previously. Monitoring these distinctive cytokine alterations could be useful for diagnosis and monitoring of canine AD in dogs. Text Canis lupus PubMed Central (PMC) Veterinary Dermatology 33 2 131 |
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Hypersensitivity Disorders |
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Hypersensitivity Disorders Mazrier, Hamutal Vogelnest, Linda J. Taylor, Rosanne M. Williamson, Peter Altered plasma cytokines in dogs with atopic dermatitis |
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Hypersensitivity Disorders |
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BACKGROUND: Canine (Canis lupus familiaris) atopic dermatitis (AD) shares similar clinical signs to human AD. The abnormal immune response of AD is orchestrated by T lymphocytes, and may include variable involvement of cytokines, regulatory T (Treg) cells, eosinophils, mast cells and other immune components. Helper T (Th)2 cytokines often predominate initially, followed by Th1 cytokines in more chronic phases. HYPOTHESIS/OBJECTIVES: Pro‐inflammatory and Treg cytokines have been shown to play a role in human AD, yet their importance is not clear in canine AD. Hence, this study aimed to measure the concentrations of cytokines/chemokines not traditionally associated with Th1/Th2 response. ANIMALS: Canine AD patients (n = 27), compared to control dogs (n = 11). METHODS AND MATERIALS: A total of 19 plasma cytokines were assayed using canine specific multiplex immuno‐assays. RESULTS: The plasma concentrations of CXC Motif Chemokine Ligand 8 (CXCL8), interleukin (IL)‐7 and IL‐15 cytokines were elevated in canine AD patients, compared to control dogs. In addition, stem‐cell factor (SCF) concentrations were reduced in the plasma of canine AD patients compared to control dogs. Distinct cytokine profiles were found in dogs belonging to the Staffordshire breeds, a group with increased risk of AD. In particular, granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) had significantly elevated concentrations. CONCLUSIONS AND CLINICAL RELEVANCE: Some of the plasma cytokine alterations in canine AD described here, particularly of IL‐7, have not been reported previously. Monitoring these distinctive cytokine alterations could be useful for diagnosis and monitoring of canine AD in dogs. |
format |
Text |
author |
Mazrier, Hamutal Vogelnest, Linda J. Taylor, Rosanne M. Williamson, Peter |
author_facet |
Mazrier, Hamutal Vogelnest, Linda J. Taylor, Rosanne M. Williamson, Peter |
author_sort |
Mazrier, Hamutal |
title |
Altered plasma cytokines in dogs with atopic dermatitis |
title_short |
Altered plasma cytokines in dogs with atopic dermatitis |
title_full |
Altered plasma cytokines in dogs with atopic dermatitis |
title_fullStr |
Altered plasma cytokines in dogs with atopic dermatitis |
title_full_unstemmed |
Altered plasma cytokines in dogs with atopic dermatitis |
title_sort |
altered plasma cytokines in dogs with atopic dermatitis |
publisher |
John Wiley and Sons Inc. |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299684/ http://www.ncbi.nlm.nih.gov/pubmed/34817106 https://doi.org/10.1111/vde.13044 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Vet Dermatol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299684/ http://www.ncbi.nlm.nih.gov/pubmed/34817106 http://dx.doi.org/10.1111/vde.13044 |
op_rights |
© 2021 The Authors. Veterinary Dermatology published by John Wiley & Sons Ltd on behalf of ESVD and ACVD https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1111/vde.13044 |
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Veterinary Dermatology |
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33 |
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2 |
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131 |
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