Host genetic factors associated with the range limit of a European hantavirus
The natural host ranges of many viruses are restricted to very specific taxa. Little is known about the molecular barriers between species that lead to the establishment of this restriction or generally prevent virus emergence in new hosts. Here, we identify genomic polymorphisms in a natural rodent...
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ftpubmed:oai:pubmedcentral.nih.gov:9298007 2023-05-15T15:56:37+02:00 Host genetic factors associated with the range limit of a European hantavirus Saxenhofer, Moritz Labutin, Anton White, Thomas A. Heckel, Gerald 2021-10-21 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298007/ http://www.ncbi.nlm.nih.gov/pubmed/34614264 https://doi.org/10.1111/mec.16211 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298007/ http://www.ncbi.nlm.nih.gov/pubmed/34614264 http://dx.doi.org/10.1111/mec.16211 © 2021 The Authors. Molecular Ecology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. CC-BY Mol Ecol ORIGINAL ARTICLES Text 2021 ftpubmed https://doi.org/10.1111/mec.16211 2022-07-31T02:15:00Z The natural host ranges of many viruses are restricted to very specific taxa. Little is known about the molecular barriers between species that lead to the establishment of this restriction or generally prevent virus emergence in new hosts. Here, we identify genomic polymorphisms in a natural rodent host associated with a strong genetic barrier to the transmission of European Tula orthohantavirus (TULV). We analysed the very abrupt spatial transition between two major phylogenetic clades in TULV across the comparatively much wider natural hybrid zone between evolutionary lineages of their reservoir host, the common vole (Microtus arvalis). Genomic scans of 79,225 single nucleotide polymorphisms (SNPs) in 323 TULV‐infected host individuals detected 30 SNPs that were consistently associated with the TULV clades CEN.S or EST.S in two replicate sampling transects. Focusing the analysis on 199 voles with evidence of genomic admixture at the individual level (0.1–0.9) supported statistical significance for all 30 loci. Host genomic variation at these SNPs explained up to 37.6% of clade‐specific TULV infections. Genes in the vicinity of associated SNPs include SAHH, ITCH and two members of the Syngr gene family, which are involved in functions related to immune response or membrane transport. This study demonstrates the relevance of natural hybrid zones as systems not only for studying processes of evolutionary divergence and speciation, but also for the detection of evolving genetic barriers for specialized parasites. Text Common vole Microtus arvalis PubMed Central (PMC) Tula ENVELOPE(-65.650,-65.650,-65.517,-65.517) Molecular Ecology 31 1 252 265 |
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ORIGINAL ARTICLES |
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ORIGINAL ARTICLES Saxenhofer, Moritz Labutin, Anton White, Thomas A. Heckel, Gerald Host genetic factors associated with the range limit of a European hantavirus |
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ORIGINAL ARTICLES |
description |
The natural host ranges of many viruses are restricted to very specific taxa. Little is known about the molecular barriers between species that lead to the establishment of this restriction or generally prevent virus emergence in new hosts. Here, we identify genomic polymorphisms in a natural rodent host associated with a strong genetic barrier to the transmission of European Tula orthohantavirus (TULV). We analysed the very abrupt spatial transition between two major phylogenetic clades in TULV across the comparatively much wider natural hybrid zone between evolutionary lineages of their reservoir host, the common vole (Microtus arvalis). Genomic scans of 79,225 single nucleotide polymorphisms (SNPs) in 323 TULV‐infected host individuals detected 30 SNPs that were consistently associated with the TULV clades CEN.S or EST.S in two replicate sampling transects. Focusing the analysis on 199 voles with evidence of genomic admixture at the individual level (0.1–0.9) supported statistical significance for all 30 loci. Host genomic variation at these SNPs explained up to 37.6% of clade‐specific TULV infections. Genes in the vicinity of associated SNPs include SAHH, ITCH and two members of the Syngr gene family, which are involved in functions related to immune response or membrane transport. This study demonstrates the relevance of natural hybrid zones as systems not only for studying processes of evolutionary divergence and speciation, but also for the detection of evolving genetic barriers for specialized parasites. |
format |
Text |
author |
Saxenhofer, Moritz Labutin, Anton White, Thomas A. Heckel, Gerald |
author_facet |
Saxenhofer, Moritz Labutin, Anton White, Thomas A. Heckel, Gerald |
author_sort |
Saxenhofer, Moritz |
title |
Host genetic factors associated with the range limit of a European hantavirus |
title_short |
Host genetic factors associated with the range limit of a European hantavirus |
title_full |
Host genetic factors associated with the range limit of a European hantavirus |
title_fullStr |
Host genetic factors associated with the range limit of a European hantavirus |
title_full_unstemmed |
Host genetic factors associated with the range limit of a European hantavirus |
title_sort |
host genetic factors associated with the range limit of a european hantavirus |
publisher |
John Wiley and Sons Inc. |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298007/ http://www.ncbi.nlm.nih.gov/pubmed/34614264 https://doi.org/10.1111/mec.16211 |
long_lat |
ENVELOPE(-65.650,-65.650,-65.517,-65.517) |
geographic |
Tula |
geographic_facet |
Tula |
genre |
Common vole Microtus arvalis |
genre_facet |
Common vole Microtus arvalis |
op_source |
Mol Ecol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298007/ http://www.ncbi.nlm.nih.gov/pubmed/34614264 http://dx.doi.org/10.1111/mec.16211 |
op_rights |
© 2021 The Authors. Molecular Ecology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1111/mec.16211 |
container_title |
Molecular Ecology |
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31 |
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1 |
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252 |
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265 |
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1766392000946372608 |