Oyster broth concentrate and its major component taurine alleviate acute alcohol‐induced liver damage
Our previous study showed that oyster hydrolysate (OH) protected against the liver damage caused by a single instance of ethanol (EtOH) binge drinking. Oyster broth concentrate (OBC) was discovered in the process of searching for a different substance derived from oysters (Crassostrea gigas) with ec...
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ftpubmed:oai:pubmedcentral.nih.gov:9281932 2023-05-15T15:58:43+02:00 Oyster broth concentrate and its major component taurine alleviate acute alcohol‐induced liver damage Siregar, Adrian S. Nyiramana, Marie Merci Kim, Eun‐Jin Shin, Eui‐Jung Woo, Min Seok Kim, Jin‐Mok Park, Si‐Hyang Hahm, Jong Ryeal Choi, Yeung Joon Kang, Dawon 2022-03-29 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281932/ http://www.ncbi.nlm.nih.gov/pubmed/35844927 https://doi.org/10.1002/fsn3.2847 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281932/ http://www.ncbi.nlm.nih.gov/pubmed/35844927 http://dx.doi.org/10.1002/fsn3.2847 © 2022 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. CC-BY Food Sci Nutr Original Articles Text 2022 ftpubmed https://doi.org/10.1002/fsn3.2847 2022-07-31T01:32:14Z Our previous study showed that oyster hydrolysate (OH) protected against the liver damage caused by a single instance of ethanol (EtOH) binge drinking. Oyster broth concentrate (OBC) was discovered in the process of searching for a different substance derived from oysters (Crassostrea gigas) with economic value. OBC is a by‐product of boiling oysters at 95°C for 3 min. In this study, we investigated the effects of OBC and its major component taurine on blood and liver tissues obtained from a single‐EtOH‐binge‐drinking mouse model. The preadministration of OBC enhanced EtOH metabolism by increasing the activities of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and catalase. In addition, the preadministration of OBC reduced cytochrome P450 2E1 (CYP2E1) activity, reactive oxygen species (ROS) generation, Ca(2+) concentrations, apoptotic signals, and inflammatory mediators in liver tissues. The reduction of apoptotic and inflammatory signals by OBC resulted from the downregulation of endoplasmic reticulum (ER) stress molecules and NF‐κB activity. Taurine administration showed similar effects to OBC. These results show that OBC protected against acute EtOH‐induced liver damage through the action of taurine. Our findings suggest that OBC could be an economically valuable substance and a functional food with hepatoprotective effects. Text Crassostrea gigas PubMed Central (PMC) Food Science & Nutrition 10 7 2390 2399 |
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Original Articles |
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Original Articles Siregar, Adrian S. Nyiramana, Marie Merci Kim, Eun‐Jin Shin, Eui‐Jung Woo, Min Seok Kim, Jin‐Mok Park, Si‐Hyang Hahm, Jong Ryeal Choi, Yeung Joon Kang, Dawon Oyster broth concentrate and its major component taurine alleviate acute alcohol‐induced liver damage |
topic_facet |
Original Articles |
description |
Our previous study showed that oyster hydrolysate (OH) protected against the liver damage caused by a single instance of ethanol (EtOH) binge drinking. Oyster broth concentrate (OBC) was discovered in the process of searching for a different substance derived from oysters (Crassostrea gigas) with economic value. OBC is a by‐product of boiling oysters at 95°C for 3 min. In this study, we investigated the effects of OBC and its major component taurine on blood and liver tissues obtained from a single‐EtOH‐binge‐drinking mouse model. The preadministration of OBC enhanced EtOH metabolism by increasing the activities of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and catalase. In addition, the preadministration of OBC reduced cytochrome P450 2E1 (CYP2E1) activity, reactive oxygen species (ROS) generation, Ca(2+) concentrations, apoptotic signals, and inflammatory mediators in liver tissues. The reduction of apoptotic and inflammatory signals by OBC resulted from the downregulation of endoplasmic reticulum (ER) stress molecules and NF‐κB activity. Taurine administration showed similar effects to OBC. These results show that OBC protected against acute EtOH‐induced liver damage through the action of taurine. Our findings suggest that OBC could be an economically valuable substance and a functional food with hepatoprotective effects. |
format |
Text |
author |
Siregar, Adrian S. Nyiramana, Marie Merci Kim, Eun‐Jin Shin, Eui‐Jung Woo, Min Seok Kim, Jin‐Mok Park, Si‐Hyang Hahm, Jong Ryeal Choi, Yeung Joon Kang, Dawon |
author_facet |
Siregar, Adrian S. Nyiramana, Marie Merci Kim, Eun‐Jin Shin, Eui‐Jung Woo, Min Seok Kim, Jin‐Mok Park, Si‐Hyang Hahm, Jong Ryeal Choi, Yeung Joon Kang, Dawon |
author_sort |
Siregar, Adrian S. |
title |
Oyster broth concentrate and its major component taurine alleviate acute alcohol‐induced liver damage |
title_short |
Oyster broth concentrate and its major component taurine alleviate acute alcohol‐induced liver damage |
title_full |
Oyster broth concentrate and its major component taurine alleviate acute alcohol‐induced liver damage |
title_fullStr |
Oyster broth concentrate and its major component taurine alleviate acute alcohol‐induced liver damage |
title_full_unstemmed |
Oyster broth concentrate and its major component taurine alleviate acute alcohol‐induced liver damage |
title_sort |
oyster broth concentrate and its major component taurine alleviate acute alcohol‐induced liver damage |
publisher |
John Wiley and Sons Inc. |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281932/ http://www.ncbi.nlm.nih.gov/pubmed/35844927 https://doi.org/10.1002/fsn3.2847 |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Food Sci Nutr |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281932/ http://www.ncbi.nlm.nih.gov/pubmed/35844927 http://dx.doi.org/10.1002/fsn3.2847 |
op_rights |
© 2022 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1002/fsn3.2847 |
container_title |
Food Science & Nutrition |
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10 |
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7 |
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2390 |
op_container_end_page |
2399 |
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1766394487752359936 |