Microbiome “Inception”: an Intestinal Cestode Shapes a Hierarchy of Microbial Communities Nested within the Host
The concept of a holobiont, a host organism and its associated microbial communities, encapsulates the vital role the microbiome plays in the normal functioning of its host. Parasitic infections can disrupt this relationship, leading to dysbiosis. However, it is increasingly recognized that multicel...
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American Society for Microbiology
2022
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239044/ http://www.ncbi.nlm.nih.gov/pubmed/35502903 https://doi.org/10.1128/mbio.00679-22 |
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ftpubmed:oai:pubmedcentral.nih.gov:9239044 2023-05-15T15:32:25+02:00 Microbiome “Inception”: an Intestinal Cestode Shapes a Hierarchy of Microbial Communities Nested within the Host Brealey, Jaelle C. Lecaudey, Laurène A. Kodama, Miyako Rasmussen, Jacob A. Sveier, Harald Dheilly, Nolwenn M. Martin, Michael D. Limborg, Morten T. 2022-05-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239044/ http://www.ncbi.nlm.nih.gov/pubmed/35502903 https://doi.org/10.1128/mbio.00679-22 en eng American Society for Microbiology http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239044/ http://www.ncbi.nlm.nih.gov/pubmed/35502903 http://dx.doi.org/10.1128/mbio.00679-22 Copyright © 2022 Brealey et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . CC-BY mBio Research Article Text 2022 ftpubmed https://doi.org/10.1128/mbio.00679-22 2022-07-03T00:58:13Z The concept of a holobiont, a host organism and its associated microbial communities, encapsulates the vital role the microbiome plays in the normal functioning of its host. Parasitic infections can disrupt this relationship, leading to dysbiosis. However, it is increasingly recognized that multicellular parasites are themselves holobionts. Intestinal parasites share space with the host gut microbiome, creating a system of nested microbiomes within the primary host. However, how the parasite, as a holobiont, interacts with the host holobiont remains unclear, as do the consequences of these interactions for host health. Here, we used 16S amplicon and shotgun metagenomics sequencing to characterize the microbiome of the intestinal cestode Eubothrium and its effect on the gut microbiome of its primary host, Atlantic salmon. Our results indicate that cestode infection is associated with salmon gut dysbiosis by acting as a selective force benefiting putative pathogens and potentially introducing novel bacterial species to the host. Our results suggest that parasitic cestodes may themselves be holobionts nested within the microbial community of their holobiont host, emphasizing the importance of also considering microbes associated with parasites when studying intestinal parasitic infections. Text Atlantic salmon PubMed Central (PMC) mBio 13 3 |
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Research Article Brealey, Jaelle C. Lecaudey, Laurène A. Kodama, Miyako Rasmussen, Jacob A. Sveier, Harald Dheilly, Nolwenn M. Martin, Michael D. Limborg, Morten T. Microbiome “Inception”: an Intestinal Cestode Shapes a Hierarchy of Microbial Communities Nested within the Host |
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Research Article |
description |
The concept of a holobiont, a host organism and its associated microbial communities, encapsulates the vital role the microbiome plays in the normal functioning of its host. Parasitic infections can disrupt this relationship, leading to dysbiosis. However, it is increasingly recognized that multicellular parasites are themselves holobionts. Intestinal parasites share space with the host gut microbiome, creating a system of nested microbiomes within the primary host. However, how the parasite, as a holobiont, interacts with the host holobiont remains unclear, as do the consequences of these interactions for host health. Here, we used 16S amplicon and shotgun metagenomics sequencing to characterize the microbiome of the intestinal cestode Eubothrium and its effect on the gut microbiome of its primary host, Atlantic salmon. Our results indicate that cestode infection is associated with salmon gut dysbiosis by acting as a selective force benefiting putative pathogens and potentially introducing novel bacterial species to the host. Our results suggest that parasitic cestodes may themselves be holobionts nested within the microbial community of their holobiont host, emphasizing the importance of also considering microbes associated with parasites when studying intestinal parasitic infections. |
format |
Text |
author |
Brealey, Jaelle C. Lecaudey, Laurène A. Kodama, Miyako Rasmussen, Jacob A. Sveier, Harald Dheilly, Nolwenn M. Martin, Michael D. Limborg, Morten T. |
author_facet |
Brealey, Jaelle C. Lecaudey, Laurène A. Kodama, Miyako Rasmussen, Jacob A. Sveier, Harald Dheilly, Nolwenn M. Martin, Michael D. Limborg, Morten T. |
author_sort |
Brealey, Jaelle C. |
title |
Microbiome “Inception”: an Intestinal Cestode Shapes a Hierarchy of Microbial Communities Nested within the Host |
title_short |
Microbiome “Inception”: an Intestinal Cestode Shapes a Hierarchy of Microbial Communities Nested within the Host |
title_full |
Microbiome “Inception”: an Intestinal Cestode Shapes a Hierarchy of Microbial Communities Nested within the Host |
title_fullStr |
Microbiome “Inception”: an Intestinal Cestode Shapes a Hierarchy of Microbial Communities Nested within the Host |
title_full_unstemmed |
Microbiome “Inception”: an Intestinal Cestode Shapes a Hierarchy of Microbial Communities Nested within the Host |
title_sort |
microbiome “inception”: an intestinal cestode shapes a hierarchy of microbial communities nested within the host |
publisher |
American Society for Microbiology |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239044/ http://www.ncbi.nlm.nih.gov/pubmed/35502903 https://doi.org/10.1128/mbio.00679-22 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
mBio |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239044/ http://www.ncbi.nlm.nih.gov/pubmed/35502903 http://dx.doi.org/10.1128/mbio.00679-22 |
op_rights |
Copyright © 2022 Brealey et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
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CC-BY |
op_doi |
https://doi.org/10.1128/mbio.00679-22 |
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mBio |
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13 |
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3 |
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1766362921039822848 |