The emergence of supergenes from inversions in Atlantic salmon
Supergenes link allelic combinations into non-recombining units known to play an essential role in maintaining adaptive genetic variation. However, because supergenes can be maintained over millions of years by balancing selection and typically exhibit strong recombination suppression, both the unde...
Published in: | Philosophical Transactions of the Royal Society B: Biological Sciences |
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189505/ http://www.ncbi.nlm.nih.gov/pubmed/35694753 https://doi.org/10.1098/rstb.2021.0195 |
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ftpubmed:oai:pubmedcentral.nih.gov:9189505 2023-08-27T04:08:30+02:00 The emergence of supergenes from inversions in Atlantic salmon Stenløkk, Kristina Saitou, Marie Rud-Johansen, Live Nome, Torfinn Moser, Michel Árnyasi, Mariann Kent, Matthew Barson, Nicola Jane Lien, Sigbjørn 2022-08-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189505/ http://www.ncbi.nlm.nih.gov/pubmed/35694753 https://doi.org/10.1098/rstb.2021.0195 en eng The Royal Society http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189505/ http://www.ncbi.nlm.nih.gov/pubmed/35694753 http://dx.doi.org/10.1098/rstb.2021.0195 © 2022 The Author(s) https://royalsociety.org/-/media/journals/author/Licence-to-Publish-20062019-final.pdfhttps://royalsociety.org/journals/ethics-policies/data-sharing-mining/Published by the Royal Society. All rights reserved. Philos Trans R Soc Lond B Biol Sci Articles Text 2022 ftpubmed https://doi.org/10.1098/rstb.2021.0195 2023-08-06T00:41:46Z Supergenes link allelic combinations into non-recombining units known to play an essential role in maintaining adaptive genetic variation. However, because supergenes can be maintained over millions of years by balancing selection and typically exhibit strong recombination suppression, both the underlying functional variants and how the supergenes are formed are largely unknown. Particularly, questions remain over the importance of inversion breakpoint sequences and whether supergenes capture pre-existing adaptive variation or accumulate this following recombination suppression. To investigate the process of supergene formation, we identified inversion polymorphisms in Atlantic salmon by assembling eleven genomes with nanopore long-read sequencing technology. A genome assembly from the sister species, brown trout, was used to determine the standard state of the inversions. We found evidence for adaptive variation through genotype–environment associations, but not for the accumulation of deleterious mutations. One young 3 Mb inversion segregating in North American populations has captured adaptive variation that is still segregating within the standard arrangement of the inversion, while some adaptive variation has accumulated after the inversion. This inversion and two others had breakpoints disrupting genes. Three multigene inversions with matched repeat structures at the breakpoints did not show any supergene signatures, suggesting that shared breakpoint repeats may obstruct supergene formation. This article is part of the theme issue ‘Genomic architecture of supergenes: causes and evolutionary consequences’. Text Atlantic salmon PubMed Central (PMC) Philosophical Transactions of the Royal Society B: Biological Sciences 377 1856 |
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Articles Stenløkk, Kristina Saitou, Marie Rud-Johansen, Live Nome, Torfinn Moser, Michel Árnyasi, Mariann Kent, Matthew Barson, Nicola Jane Lien, Sigbjørn The emergence of supergenes from inversions in Atlantic salmon |
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Articles |
description |
Supergenes link allelic combinations into non-recombining units known to play an essential role in maintaining adaptive genetic variation. However, because supergenes can be maintained over millions of years by balancing selection and typically exhibit strong recombination suppression, both the underlying functional variants and how the supergenes are formed are largely unknown. Particularly, questions remain over the importance of inversion breakpoint sequences and whether supergenes capture pre-existing adaptive variation or accumulate this following recombination suppression. To investigate the process of supergene formation, we identified inversion polymorphisms in Atlantic salmon by assembling eleven genomes with nanopore long-read sequencing technology. A genome assembly from the sister species, brown trout, was used to determine the standard state of the inversions. We found evidence for adaptive variation through genotype–environment associations, but not for the accumulation of deleterious mutations. One young 3 Mb inversion segregating in North American populations has captured adaptive variation that is still segregating within the standard arrangement of the inversion, while some adaptive variation has accumulated after the inversion. This inversion and two others had breakpoints disrupting genes. Three multigene inversions with matched repeat structures at the breakpoints did not show any supergene signatures, suggesting that shared breakpoint repeats may obstruct supergene formation. This article is part of the theme issue ‘Genomic architecture of supergenes: causes and evolutionary consequences’. |
format |
Text |
author |
Stenløkk, Kristina Saitou, Marie Rud-Johansen, Live Nome, Torfinn Moser, Michel Árnyasi, Mariann Kent, Matthew Barson, Nicola Jane Lien, Sigbjørn |
author_facet |
Stenløkk, Kristina Saitou, Marie Rud-Johansen, Live Nome, Torfinn Moser, Michel Árnyasi, Mariann Kent, Matthew Barson, Nicola Jane Lien, Sigbjørn |
author_sort |
Stenløkk, Kristina |
title |
The emergence of supergenes from inversions in Atlantic salmon |
title_short |
The emergence of supergenes from inversions in Atlantic salmon |
title_full |
The emergence of supergenes from inversions in Atlantic salmon |
title_fullStr |
The emergence of supergenes from inversions in Atlantic salmon |
title_full_unstemmed |
The emergence of supergenes from inversions in Atlantic salmon |
title_sort |
emergence of supergenes from inversions in atlantic salmon |
publisher |
The Royal Society |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189505/ http://www.ncbi.nlm.nih.gov/pubmed/35694753 https://doi.org/10.1098/rstb.2021.0195 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Philos Trans R Soc Lond B Biol Sci |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189505/ http://www.ncbi.nlm.nih.gov/pubmed/35694753 http://dx.doi.org/10.1098/rstb.2021.0195 |
op_rights |
© 2022 The Author(s) https://royalsociety.org/-/media/journals/author/Licence-to-Publish-20062019-final.pdfhttps://royalsociety.org/journals/ethics-policies/data-sharing-mining/Published by the Royal Society. All rights reserved. |
op_doi |
https://doi.org/10.1098/rstb.2021.0195 |
container_title |
Philosophical Transactions of the Royal Society B: Biological Sciences |
container_volume |
377 |
container_issue |
1856 |
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1775349312180453376 |