Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort
PURPOSE: The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, particularly allergies and respiratory health, (2) identify susceptible time windows...
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ftpubmed:oai:pubmedcentral.nih.gov:9163543 2023-05-15T16:51:36+02:00 Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort Svanes, Cecilie Johannessen, Ane Bertelsen, Randi Jacobsen Dharmage, Shyamali Benediktsdottir, Bryndis Bråbäck, Lennart Gislason, Thorarinn Holm, Mathias Jõgi, Oskar Lodge, Caroline J Malinovschi, Andrei Martinez-Moratalla, Jesus Oudin, Anna Sánchez-Ramos, José Luis Timm, Signe Janson, Christer Real, Francisco Gomez Schlünssen, Vivi 2022-06-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163543/ http://www.ncbi.nlm.nih.gov/pubmed/35654464 https://doi.org/10.1136/bmjopen-2021-059434 en eng BMJ Publishing Group http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163543/ http://www.ncbi.nlm.nih.gov/pubmed/35654464 http://dx.doi.org/10.1136/bmjopen-2021-059434 © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. CC-BY BMJ Open Epidemiology Text 2022 ftpubmed https://doi.org/10.1136/bmjopen-2021-059434 2022-06-19T00:34:40Z PURPOSE: The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, particularly allergies and respiratory health, (2) identify susceptible time windows and (3) explore underlying mechanisms. The ultimate aim is to facilitate efficient intervention strategies targeting multiple generations. PARTICIPANTS: RHINESSA includes study participants of multiple generations from ten study centres in Norway (1), Denmark (1), Sweden (3), Iceland (1), Estonia (1), Spain (2) and Australia (1). The RHINESSA core cohort, adult offspring generation 3 (G3), was first investigated in 2014–17 in a questionnaire study (N=8818, age 18–53 years) and a clinical study (subsample, n=1405). Their G2 parents participated in the population-based cohorts, European Community Respiratory Heath Survey and Respiratory Health In Northern Europe, followed since the early 1990s when they were 20–44 years old, at 8–10 years intervals. Study protocols are harmonised across generations. FINDINGS TO DATE: Collected data include spirometry, skin prick tests, exhaled nitric oxide, anthropometrics, bioimpedance, blood pressure; questionnaire/interview data on respiratory/general/reproductive health, indoor/outdoor environment, smoking, occupation, general characteristics and lifestyle; biobanked blood, urine, gingival fluid, skin swabs; measured specific and total IgE, DNA methylation, sex hormones and oral microbiome. Research results suggest that parental environment years before conception, in particular, father’s exposures such as smoking and overweight, may be of key importance for asthma and lung function, and that there is an important susceptibility window in male prepuberty. Statistical analyses developed to approach causal inference suggest that these associations may be causal. DNA methylation studies suggest a mechanism for transfer of father’s exposures to offspring health and disease through ... Text Iceland PubMed Central (PMC) Norway BMJ Open 12 6 e059434 |
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Epidemiology |
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Epidemiology Svanes, Cecilie Johannessen, Ane Bertelsen, Randi Jacobsen Dharmage, Shyamali Benediktsdottir, Bryndis Bråbäck, Lennart Gislason, Thorarinn Holm, Mathias Jõgi, Oskar Lodge, Caroline J Malinovschi, Andrei Martinez-Moratalla, Jesus Oudin, Anna Sánchez-Ramos, José Luis Timm, Signe Janson, Christer Real, Francisco Gomez Schlünssen, Vivi Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
topic_facet |
Epidemiology |
description |
PURPOSE: The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, particularly allergies and respiratory health, (2) identify susceptible time windows and (3) explore underlying mechanisms. The ultimate aim is to facilitate efficient intervention strategies targeting multiple generations. PARTICIPANTS: RHINESSA includes study participants of multiple generations from ten study centres in Norway (1), Denmark (1), Sweden (3), Iceland (1), Estonia (1), Spain (2) and Australia (1). The RHINESSA core cohort, adult offspring generation 3 (G3), was first investigated in 2014–17 in a questionnaire study (N=8818, age 18–53 years) and a clinical study (subsample, n=1405). Their G2 parents participated in the population-based cohorts, European Community Respiratory Heath Survey and Respiratory Health In Northern Europe, followed since the early 1990s when they were 20–44 years old, at 8–10 years intervals. Study protocols are harmonised across generations. FINDINGS TO DATE: Collected data include spirometry, skin prick tests, exhaled nitric oxide, anthropometrics, bioimpedance, blood pressure; questionnaire/interview data on respiratory/general/reproductive health, indoor/outdoor environment, smoking, occupation, general characteristics and lifestyle; biobanked blood, urine, gingival fluid, skin swabs; measured specific and total IgE, DNA methylation, sex hormones and oral microbiome. Research results suggest that parental environment years before conception, in particular, father’s exposures such as smoking and overweight, may be of key importance for asthma and lung function, and that there is an important susceptibility window in male prepuberty. Statistical analyses developed to approach causal inference suggest that these associations may be causal. DNA methylation studies suggest a mechanism for transfer of father’s exposures to offspring health and disease through ... |
format |
Text |
author |
Svanes, Cecilie Johannessen, Ane Bertelsen, Randi Jacobsen Dharmage, Shyamali Benediktsdottir, Bryndis Bråbäck, Lennart Gislason, Thorarinn Holm, Mathias Jõgi, Oskar Lodge, Caroline J Malinovschi, Andrei Martinez-Moratalla, Jesus Oudin, Anna Sánchez-Ramos, José Luis Timm, Signe Janson, Christer Real, Francisco Gomez Schlünssen, Vivi |
author_facet |
Svanes, Cecilie Johannessen, Ane Bertelsen, Randi Jacobsen Dharmage, Shyamali Benediktsdottir, Bryndis Bråbäck, Lennart Gislason, Thorarinn Holm, Mathias Jõgi, Oskar Lodge, Caroline J Malinovschi, Andrei Martinez-Moratalla, Jesus Oudin, Anna Sánchez-Ramos, José Luis Timm, Signe Janson, Christer Real, Francisco Gomez Schlünssen, Vivi |
author_sort |
Svanes, Cecilie |
title |
Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
title_short |
Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
title_full |
Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
title_fullStr |
Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
title_full_unstemmed |
Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
title_sort |
cohort profile: the multigeneration respiratory health in northern europe, spain and australia (rhinessa) cohort |
publisher |
BMJ Publishing Group |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163543/ http://www.ncbi.nlm.nih.gov/pubmed/35654464 https://doi.org/10.1136/bmjopen-2021-059434 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
BMJ Open |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163543/ http://www.ncbi.nlm.nih.gov/pubmed/35654464 http://dx.doi.org/10.1136/bmjopen-2021-059434 |
op_rights |
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1136/bmjopen-2021-059434 |
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BMJ Open |
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12 |
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6 |
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e059434 |
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