Late effects and survival of children with malignant solid tumours in northern Finland: a single-centre cohort study
The global survival rates for childhood cancers are high: approximately 80% of affected children will survive. Nevertheless, the burden of treatment for survivors is also high as three-quarters experience late effects of varying severity following cancer treatment. The aims of this study were to eva...
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ftpubmed:oai:pubmedcentral.nih.gov:9110514 2023-05-15T17:42:16+02:00 Late effects and survival of children with malignant solid tumours in northern Finland: a single-centre cohort study Kortelainen, Sanni Harju, Tekla Juntti, Hanna Pokka, Tytti Niinimäki, Riitta 2022-02-24 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110514/ http://www.ncbi.nlm.nih.gov/pubmed/35199241 https://doi.org/10.1007/s00431-022-04399-7 en eng Springer Berlin Heidelberg http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110514/ http://www.ncbi.nlm.nih.gov/pubmed/35199241 http://dx.doi.org/10.1007/s00431-022-04399-7 © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . CC-BY Eur J Pediatr Original Article Text 2022 ftpubmed https://doi.org/10.1007/s00431-022-04399-7 2022-05-22T00:43:05Z The global survival rates for childhood cancers are high: approximately 80% of affected children will survive. Nevertheless, the burden of treatment for survivors is also high as three-quarters experience late effects of varying severity following cancer treatment. The aims of this study were to evaluate the treatment-related late effects of patients with childhood solid tumour in northern Finland and to report their survival rates. Our study included 104 patients treated for malignant solid tumours, excluding central nervous system tumours and lymphomas, between 1990 and 2015. Information regarding the type of late effects as well as other clinical data were obtained from the patients’ medical records. Late effects were observed in 65 (63%) patients, and almost half (40%) of the patients displayed more than one late effect. The most common late effect was hearing loss (n = 20). The 5-year survival rate in our study was 75%. Conclusion: Our results highlight the importance of long-term follow-up for childhood cancer survivors. As survivors age and survival rates improve, late effects and their impact on patient health as well as the value of surveillance must be considered. Text Northern Finland PubMed Central (PMC) European Journal of Pediatrics 181 6 2263 2272 |
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Original Article Kortelainen, Sanni Harju, Tekla Juntti, Hanna Pokka, Tytti Niinimäki, Riitta Late effects and survival of children with malignant solid tumours in northern Finland: a single-centre cohort study |
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Original Article |
description |
The global survival rates for childhood cancers are high: approximately 80% of affected children will survive. Nevertheless, the burden of treatment for survivors is also high as three-quarters experience late effects of varying severity following cancer treatment. The aims of this study were to evaluate the treatment-related late effects of patients with childhood solid tumour in northern Finland and to report their survival rates. Our study included 104 patients treated for malignant solid tumours, excluding central nervous system tumours and lymphomas, between 1990 and 2015. Information regarding the type of late effects as well as other clinical data were obtained from the patients’ medical records. Late effects were observed in 65 (63%) patients, and almost half (40%) of the patients displayed more than one late effect. The most common late effect was hearing loss (n = 20). The 5-year survival rate in our study was 75%. Conclusion: Our results highlight the importance of long-term follow-up for childhood cancer survivors. As survivors age and survival rates improve, late effects and their impact on patient health as well as the value of surveillance must be considered. |
format |
Text |
author |
Kortelainen, Sanni Harju, Tekla Juntti, Hanna Pokka, Tytti Niinimäki, Riitta |
author_facet |
Kortelainen, Sanni Harju, Tekla Juntti, Hanna Pokka, Tytti Niinimäki, Riitta |
author_sort |
Kortelainen, Sanni |
title |
Late effects and survival of children with malignant solid tumours in northern Finland: a single-centre cohort study |
title_short |
Late effects and survival of children with malignant solid tumours in northern Finland: a single-centre cohort study |
title_full |
Late effects and survival of children with malignant solid tumours in northern Finland: a single-centre cohort study |
title_fullStr |
Late effects and survival of children with malignant solid tumours in northern Finland: a single-centre cohort study |
title_full_unstemmed |
Late effects and survival of children with malignant solid tumours in northern Finland: a single-centre cohort study |
title_sort |
late effects and survival of children with malignant solid tumours in northern finland: a single-centre cohort study |
publisher |
Springer Berlin Heidelberg |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110514/ http://www.ncbi.nlm.nih.gov/pubmed/35199241 https://doi.org/10.1007/s00431-022-04399-7 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Eur J Pediatr |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110514/ http://www.ncbi.nlm.nih.gov/pubmed/35199241 http://dx.doi.org/10.1007/s00431-022-04399-7 |
op_rights |
© The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s00431-022-04399-7 |
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European Journal of Pediatrics |
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181 |
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6 |
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2263 |
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2272 |
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1766144112606576640 |