Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway
BACKGROUND: Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-...
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BioMed Central
2022
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008943/ https://doi.org/10.1186/s12882-022-02738-2 |
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Research Cook, Sarah Solbu, Marit D. Eggen, Anne Elise Iakunchykova, Olena Averina, Maria Hopstock, Laila A. Kholmatova, Kamila Kudryavtsev, Alexander V. Leon, David A. Malyutina, Sofia Ryabikov, Andrew Williamson, Elizabeth Nitsch, Dorothea Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway |
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Research |
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BACKGROUND: Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-study differences in CKD. METHODS: We compared age- and sex-standardised prevalence of reduced eGFR (< 60 ml/min/1.73m(2) CKD-EPI creatinine equation), albuminuria and or a composite indicator of CKD (one measure of either reduced eGFR or albuminuria) between participants aged 40–69 in the population-based Know Your Heart (KYH) study, Russia (2015–2018 N = 4607) and the seventh Tromsø Study (Tromsø7), Norway (2015–2016 N = 17,646). We assessed the contribution of established CKD risk factors (low education, diabetes, hypertension, antihypertensive use, smoking, obesity) to between-study differences using logistic regression. RESULTS: Prevalence of reduced eGFR or albuminuria was 6.5% (95% Confidence Interval (CI) 5.4, 7.7) in KYH and 4.6% (95% CI 4.0, 5.2) in Tromsø7 standardised for sex and age. Odds of both clinical outcomes were higher in KYH than Tromsø7 (reduced eGFR OR 2.06 95% CI 1.67, 2.54; albuminuria OR 1.54 95% CI 1.16, 2.03) adjusted for sex and age. Risk factor adjustment explained the observed between-study difference in albuminuria (OR 0.92 95% CI 0.68, 1.25) but only partially reduced eGFR (OR 1.42 95% CI 1.11, 1.82). The strongest explanatory factors for the between-study difference was higher use of antihypertensives (Russian sample) for reduced eGFR and mean diastolic blood pressure for albuminuria. CONCLUSIONS: We found evidence of a higher burden of CKD within the sample from the population in Arkhangelsk and Novosibirsk compared to Tromsø, partly explained by between-study population differences in established risk factors. In particular hypertension defined by medication use was an important factor associated with the higher CKD prevalence in the Russian sample. SUPPLEMENTARY INFORMATION: The ... |
format |
Text |
author |
Cook, Sarah Solbu, Marit D. Eggen, Anne Elise Iakunchykova, Olena Averina, Maria Hopstock, Laila A. Kholmatova, Kamila Kudryavtsev, Alexander V. Leon, David A. Malyutina, Sofia Ryabikov, Andrew Williamson, Elizabeth Nitsch, Dorothea |
author_facet |
Cook, Sarah Solbu, Marit D. Eggen, Anne Elise Iakunchykova, Olena Averina, Maria Hopstock, Laila A. Kholmatova, Kamila Kudryavtsev, Alexander V. Leon, David A. Malyutina, Sofia Ryabikov, Andrew Williamson, Elizabeth Nitsch, Dorothea |
author_sort |
Cook, Sarah |
title |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway |
title_short |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway |
title_full |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway |
title_fullStr |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway |
title_full_unstemmed |
Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway |
title_sort |
comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in russia and norway |
publisher |
BioMed Central |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008943/ https://doi.org/10.1186/s12882-022-02738-2 |
geographic |
Norway Tromsø |
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Norway Tromsø |
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Arkhangelsk Tromsø |
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Arkhangelsk Tromsø |
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BMC Nephrol |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008943/ http://dx.doi.org/10.1186/s12882-022-02738-2 |
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© The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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https://doi.org/10.1186/s12882-022-02738-2 |
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BMC Nephrology |
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23 |
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1 |
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1766354602535419904 |
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ftpubmed:oai:pubmedcentral.nih.gov:9008943 2023-05-15T15:24:02+02:00 Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway Cook, Sarah Solbu, Marit D. Eggen, Anne Elise Iakunchykova, Olena Averina, Maria Hopstock, Laila A. Kholmatova, Kamila Kudryavtsev, Alexander V. Leon, David A. Malyutina, Sofia Ryabikov, Andrew Williamson, Elizabeth Nitsch, Dorothea 2022-04-14 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008943/ https://doi.org/10.1186/s12882-022-02738-2 en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008943/ http://dx.doi.org/10.1186/s12882-022-02738-2 © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. CC0 PDM CC-BY BMC Nephrol Research Text 2022 ftpubmed https://doi.org/10.1186/s12882-022-02738-2 2022-04-17T01:20:03Z BACKGROUND: Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-study differences in CKD. METHODS: We compared age- and sex-standardised prevalence of reduced eGFR (< 60 ml/min/1.73m(2) CKD-EPI creatinine equation), albuminuria and or a composite indicator of CKD (one measure of either reduced eGFR or albuminuria) between participants aged 40–69 in the population-based Know Your Heart (KYH) study, Russia (2015–2018 N = 4607) and the seventh Tromsø Study (Tromsø7), Norway (2015–2016 N = 17,646). We assessed the contribution of established CKD risk factors (low education, diabetes, hypertension, antihypertensive use, smoking, obesity) to between-study differences using logistic regression. RESULTS: Prevalence of reduced eGFR or albuminuria was 6.5% (95% Confidence Interval (CI) 5.4, 7.7) in KYH and 4.6% (95% CI 4.0, 5.2) in Tromsø7 standardised for sex and age. Odds of both clinical outcomes were higher in KYH than Tromsø7 (reduced eGFR OR 2.06 95% CI 1.67, 2.54; albuminuria OR 1.54 95% CI 1.16, 2.03) adjusted for sex and age. Risk factor adjustment explained the observed between-study difference in albuminuria (OR 0.92 95% CI 0.68, 1.25) but only partially reduced eGFR (OR 1.42 95% CI 1.11, 1.82). The strongest explanatory factors for the between-study difference was higher use of antihypertensives (Russian sample) for reduced eGFR and mean diastolic blood pressure for albuminuria. CONCLUSIONS: We found evidence of a higher burden of CKD within the sample from the population in Arkhangelsk and Novosibirsk compared to Tromsø, partly explained by between-study population differences in established risk factors. In particular hypertension defined by medication use was an important factor associated with the higher CKD prevalence in the Russian sample. SUPPLEMENTARY INFORMATION: The ... Text Arkhangelsk Tromsø PubMed Central (PMC) Norway Tromsø BMC Nephrology 23 1 |