Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats
The laryngeal echolocation is regarded as one of the conspicuous traits that play major roles in flourishing bats. Whether the laryngeal echolocation in bats originated once, however, is still controversial. We here address this question by performing molecular convergence analyses between ancestral...
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ftpubmed:oai:pubmedcentral.nih.gov:8980745 2023-05-15T18:33:31+02:00 Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats Liu, Zhen Chen, Peng Xu, Dong-Ming Qi, Fei-Yan Guo, Yuan-Ting Liu, Qi Bai, Jing Zhou, Xin Shi, Peng 2022-03-18 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980745/ https://doi.org/10.1016/j.isci.2022.104114 en eng Elsevier http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980745/ http://dx.doi.org/10.1016/j.isci.2022.104114 © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). CC-BY-NC-ND iScience Article Text 2022 ftpubmed https://doi.org/10.1016/j.isci.2022.104114 2022-04-10T00:43:03Z The laryngeal echolocation is regarded as one of the conspicuous traits that play major roles in flourishing bats. Whether the laryngeal echolocation in bats originated once, however, is still controversial. We here address this question by performing molecular convergence analyses between ancestral branches of bats and toothed whales. Compared with controls, the molecular convergences were enriched in hearing-related genes for the last common ancestor of bats (LCAB) and extant echolocating bats, but not for the LCA of Old World fruit bats (LCAP). And the convergent hearing gene prestin of the LCAB and the extant echolocating bats functionally converged. More importantly, the high-frequency hearing of the LCAP-prestin knock-in mice decreased with lower cochlear outer hair cell function compared with the LCAB-prestin knock-in mice. Together, our findings provide multiple lines of evidence suggesting a single origin of laryngeal echolocation in the LCAB and the subsequent loss in the LCAP. Text toothed whales PubMed Central (PMC) iScience 25 4 104114 |
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Article Liu, Zhen Chen, Peng Xu, Dong-Ming Qi, Fei-Yan Guo, Yuan-Ting Liu, Qi Bai, Jing Zhou, Xin Shi, Peng Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats |
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The laryngeal echolocation is regarded as one of the conspicuous traits that play major roles in flourishing bats. Whether the laryngeal echolocation in bats originated once, however, is still controversial. We here address this question by performing molecular convergence analyses between ancestral branches of bats and toothed whales. Compared with controls, the molecular convergences were enriched in hearing-related genes for the last common ancestor of bats (LCAB) and extant echolocating bats, but not for the LCA of Old World fruit bats (LCAP). And the convergent hearing gene prestin of the LCAB and the extant echolocating bats functionally converged. More importantly, the high-frequency hearing of the LCAP-prestin knock-in mice decreased with lower cochlear outer hair cell function compared with the LCAB-prestin knock-in mice. Together, our findings provide multiple lines of evidence suggesting a single origin of laryngeal echolocation in the LCAB and the subsequent loss in the LCAP. |
format |
Text |
author |
Liu, Zhen Chen, Peng Xu, Dong-Ming Qi, Fei-Yan Guo, Yuan-Ting Liu, Qi Bai, Jing Zhou, Xin Shi, Peng |
author_facet |
Liu, Zhen Chen, Peng Xu, Dong-Ming Qi, Fei-Yan Guo, Yuan-Ting Liu, Qi Bai, Jing Zhou, Xin Shi, Peng |
author_sort |
Liu, Zhen |
title |
Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats |
title_short |
Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats |
title_full |
Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats |
title_fullStr |
Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats |
title_full_unstemmed |
Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats |
title_sort |
molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats |
publisher |
Elsevier |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980745/ https://doi.org/10.1016/j.isci.2022.104114 |
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toothed whales |
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toothed whales |
op_source |
iScience |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980745/ http://dx.doi.org/10.1016/j.isci.2022.104114 |
op_rights |
© 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.isci.2022.104114 |
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25 |
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104114 |
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