Short-term exposure to fine particulate matter and its constituents may affect renal function via oxidative stress: A longitudinal panel study
Exposure to fine particulate matter (PM(2.)(5)) has been reported to increase the risks of chronic kidney disease. However, limited research has assessed the effect of PM(2.5) and its constituents on renal function, and the underlying mechanism has not been well characterized. We aimed to evaluate t...
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ftpubmed:oai:pubmedcentral.nih.gov:8976286 2023-05-15T16:55:50+02:00 Short-term exposure to fine particulate matter and its constituents may affect renal function via oxidative stress: A longitudinal panel study Peng, Shouxin Lu, Tianjun Liu, Yisi Li, Zhaoyuan Liu, Feifei Sun, Jinhui Chen, Meijin Wang, Huaiji Xiang, Hao 2022-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976286/ http://www.ncbi.nlm.nih.gov/pubmed/35007609 https://doi.org/10.1016/j.chemosphere.2022.133570 en eng Elsevier Science Ltd http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976286/ http://www.ncbi.nlm.nih.gov/pubmed/35007609 http://dx.doi.org/10.1016/j.chemosphere.2022.133570 © 2022 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). CC-BY Chemosphere Article Text 2022 ftpubmed https://doi.org/10.1016/j.chemosphere.2022.133570 2022-05-08T00:39:07Z Exposure to fine particulate matter (PM(2.)(5)) has been reported to increase the risks of chronic kidney disease. However, limited research has assessed the effect of PM(2.5) and its constituents on renal function, and the underlying mechanism has not been well characterized. We aimed to evaluate the association of PM(2.5) and its constituents with kidney indicators and to explore the roles of systematic oxidative stress and inflammation in the association. We conducted a longitudinal panel study among 35 healthy adults before-, intra- and after-the 2019 Wuhan Military World Games. We repeatedly measured 6 renal function parameters and 5 circulating biomarkers of oxidative stress and inflammation at 6 rounds of follow-ups. We monitored hourly personal PM(2.5) concentrations with 3 consecutive days and measured 10 metals (metalloids) and 16 polycyclic aromatic hydrocarbons (PAHs) components. The linear mixed-effect models were applied to examine the association between PM(2.5) and renal function parameters, and the mediation analysis was performed to explore potential bio-pathways. PM(2.5) concentrations across Wuhan showed a slight decrease during the Military Games. We observed significant associations between elevated blood urea nitrogen (BUN) levels and PM(2.5) and its several metals and PAHs components. For an interquartile range (IQR) increase of PM(2.5), BUN increased 0.42 mmol/L (95% CI: 0.14 to 0.69). On average, an IQR higher of lead (Pb), cadmium (Cd), arsenic (As), selenium (Se), thallium (Tl) and Indeno (1,2,3-cd) pyrene (IPY) were associated with 0.90, 0.65, 0.29, 0.27, 0.26 and 0.90 mmol/L increment of BUN, respectively. Moreover, superoxide dismutase was positively associated with PM(2.5) and mediated 18.24% association. Our research indicated that exposure to PM(2.5) might affect renal function by activating oxidative stress pathways, in which the constituents of Pb, Cd, As, Se, Tl and IPY might contribute to the associations. Text IPY PubMed Central (PMC) Chemosphere 293 133570 |
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Article Peng, Shouxin Lu, Tianjun Liu, Yisi Li, Zhaoyuan Liu, Feifei Sun, Jinhui Chen, Meijin Wang, Huaiji Xiang, Hao Short-term exposure to fine particulate matter and its constituents may affect renal function via oxidative stress: A longitudinal panel study |
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Exposure to fine particulate matter (PM(2.)(5)) has been reported to increase the risks of chronic kidney disease. However, limited research has assessed the effect of PM(2.5) and its constituents on renal function, and the underlying mechanism has not been well characterized. We aimed to evaluate the association of PM(2.5) and its constituents with kidney indicators and to explore the roles of systematic oxidative stress and inflammation in the association. We conducted a longitudinal panel study among 35 healthy adults before-, intra- and after-the 2019 Wuhan Military World Games. We repeatedly measured 6 renal function parameters and 5 circulating biomarkers of oxidative stress and inflammation at 6 rounds of follow-ups. We monitored hourly personal PM(2.5) concentrations with 3 consecutive days and measured 10 metals (metalloids) and 16 polycyclic aromatic hydrocarbons (PAHs) components. The linear mixed-effect models were applied to examine the association between PM(2.5) and renal function parameters, and the mediation analysis was performed to explore potential bio-pathways. PM(2.5) concentrations across Wuhan showed a slight decrease during the Military Games. We observed significant associations between elevated blood urea nitrogen (BUN) levels and PM(2.5) and its several metals and PAHs components. For an interquartile range (IQR) increase of PM(2.5), BUN increased 0.42 mmol/L (95% CI: 0.14 to 0.69). On average, an IQR higher of lead (Pb), cadmium (Cd), arsenic (As), selenium (Se), thallium (Tl) and Indeno (1,2,3-cd) pyrene (IPY) were associated with 0.90, 0.65, 0.29, 0.27, 0.26 and 0.90 mmol/L increment of BUN, respectively. Moreover, superoxide dismutase was positively associated with PM(2.5) and mediated 18.24% association. Our research indicated that exposure to PM(2.5) might affect renal function by activating oxidative stress pathways, in which the constituents of Pb, Cd, As, Se, Tl and IPY might contribute to the associations. |
format |
Text |
author |
Peng, Shouxin Lu, Tianjun Liu, Yisi Li, Zhaoyuan Liu, Feifei Sun, Jinhui Chen, Meijin Wang, Huaiji Xiang, Hao |
author_facet |
Peng, Shouxin Lu, Tianjun Liu, Yisi Li, Zhaoyuan Liu, Feifei Sun, Jinhui Chen, Meijin Wang, Huaiji Xiang, Hao |
author_sort |
Peng, Shouxin |
title |
Short-term exposure to fine particulate matter and its constituents may affect renal function via oxidative stress: A longitudinal panel study |
title_short |
Short-term exposure to fine particulate matter and its constituents may affect renal function via oxidative stress: A longitudinal panel study |
title_full |
Short-term exposure to fine particulate matter and its constituents may affect renal function via oxidative stress: A longitudinal panel study |
title_fullStr |
Short-term exposure to fine particulate matter and its constituents may affect renal function via oxidative stress: A longitudinal panel study |
title_full_unstemmed |
Short-term exposure to fine particulate matter and its constituents may affect renal function via oxidative stress: A longitudinal panel study |
title_sort |
short-term exposure to fine particulate matter and its constituents may affect renal function via oxidative stress: a longitudinal panel study |
publisher |
Elsevier Science Ltd |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976286/ http://www.ncbi.nlm.nih.gov/pubmed/35007609 https://doi.org/10.1016/j.chemosphere.2022.133570 |
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IPY |
genre_facet |
IPY |
op_source |
Chemosphere |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976286/ http://www.ncbi.nlm.nih.gov/pubmed/35007609 http://dx.doi.org/10.1016/j.chemosphere.2022.133570 |
op_rights |
© 2022 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1016/j.chemosphere.2022.133570 |
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Chemosphere |
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293 |
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133570 |
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