An Efficient Synthesis of 3-Alkylpyridine Alkaloids Enables Their Biological Evaluation
3-Alkylpyridine alkaloids (3-APAs) isolated from the arctic sponge Haliclona viscosa are a promising group of bioactive marine alkaloids. However, due to limited bioavailability, investigations of their bioactivity have been hampered. Additionally, synthesis of a common intermediate requires the use...
Published in: | ChemMedChem |
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Main Authors: | , , |
Format: | Text |
Language: | English |
Published: |
2021
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Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895759/ http://www.ncbi.nlm.nih.gov/pubmed/33755337 https://doi.org/10.1002/cmdc.202100134 |
Summary: | 3-Alkylpyridine alkaloids (3-APAs) isolated from the arctic sponge Haliclona viscosa are a promising group of bioactive marine alkaloids. However, due to limited bioavailability, investigations of their bioactivity have been hampered. Additionally, synthesis of a common intermediate requires the use of protecting groups and harsh conditions. In this work, we developed a simple and concise two-step route to nine different natural and synthetic haliclocyclins. These compounds displayed modest antibiotic activity against several Gram-positive bacterial strains. |
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