Differential DNA methylation in Black and White individuals with chronic low back pain enrich different genomic pathways

• Published in: Neurobiology of Pain
• Main Authors: Aroke, Edwin N., Jackson, Pamela, Meng, Lingsong, Huo, Zhiguang, Overstreet, Demario S., Penn, Terence M., Quinn, Tammie L., Cruz-Almeida, Yenisel, Goodin, Burel R.
• Format: Text
• Language: English
• Published: Elsevier 2022
• Subjects: Original Research Article; Browning; DML
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885563/; https://doi.org/10.1016/j.ynpai.2022.100086

Compared to Non-Hispanic Whites (NHWs), individuals who self-identify as Non-Hispanic Blacks (NHBs) in the United States experience more severe and disabling chronic low back pain (cLBP). We hypothesized that differences in DNA methylation (DNAm) play a role in racial disparities in cLBP. PURPOSE: T...