Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity
The mitochondrial oxidative stress theory of aging suggests that the organelle’s decay contributes to the aging phenotype via exacerbated oxidative stress, loss of organ coordination and energetics, cellular integrity, and activity of the mitochondrial electron transfer system (ETS). Recent advances...
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ftpubmed:oai:pubmedcentral.nih.gov:8824617 2023-05-15T15:22:33+02:00 Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity Rodríguez, Enrique Radke, Amanda Hagen, Tory M Blier, Pierre U 2021-12-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824617/ http://www.ncbi.nlm.nih.gov/pubmed/34871395 https://doi.org/10.1093/gerona/glab363 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824617/ http://www.ncbi.nlm.nih.gov/pubmed/34871395 http://dx.doi.org/10.1093/gerona/glab363 © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) J Gerontol A Biol Sci Med Sci THE JOURNAL OF GERONTOLOGY: Biological Sciences Text 2021 ftpubmed https://doi.org/10.1093/gerona/glab363 2022-12-11T01:30:44Z The mitochondrial oxidative stress theory of aging suggests that the organelle’s decay contributes to the aging phenotype via exacerbated oxidative stress, loss of organ coordination and energetics, cellular integrity, and activity of the mitochondrial electron transfer system (ETS). Recent advances in understanding the structure of the ETS show that the enzymatic complexes responsible for oxidative phosphorylation are arranged in supramolecular structures called supercomplexes that lose organization during aging. Their exact role and universality among organisms are still under debate. Here, we take advantage of marine bivalves as an aging model to compare the structure of the ETS among species ranging from 28 to 507 years in maximal life span. Our results show that regardless of life span, the bivalve ETS is arrayed as a set of supercomplexes. However, bivalve species display varying degrees of ETS supramolecular organization with the highest supercomplex structures found in Arctica islandica, the longest-lived of the bivalve species under study. We discuss this comparative model in light of differences in the nature and stoichiometry of these complexes and highlight the potential link between the complexity of these superstructures and longer life spans. Text Arctica islandica PubMed Central (PMC) The Journals of Gerontology: Series A 77 2 283 290 |
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THE JOURNAL OF GERONTOLOGY: Biological Sciences |
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THE JOURNAL OF GERONTOLOGY: Biological Sciences Rodríguez, Enrique Radke, Amanda Hagen, Tory M Blier, Pierre U Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity |
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THE JOURNAL OF GERONTOLOGY: Biological Sciences |
description |
The mitochondrial oxidative stress theory of aging suggests that the organelle’s decay contributes to the aging phenotype via exacerbated oxidative stress, loss of organ coordination and energetics, cellular integrity, and activity of the mitochondrial electron transfer system (ETS). Recent advances in understanding the structure of the ETS show that the enzymatic complexes responsible for oxidative phosphorylation are arranged in supramolecular structures called supercomplexes that lose organization during aging. Their exact role and universality among organisms are still under debate. Here, we take advantage of marine bivalves as an aging model to compare the structure of the ETS among species ranging from 28 to 507 years in maximal life span. Our results show that regardless of life span, the bivalve ETS is arrayed as a set of supercomplexes. However, bivalve species display varying degrees of ETS supramolecular organization with the highest supercomplex structures found in Arctica islandica, the longest-lived of the bivalve species under study. We discuss this comparative model in light of differences in the nature and stoichiometry of these complexes and highlight the potential link between the complexity of these superstructures and longer life spans. |
format |
Text |
author |
Rodríguez, Enrique Radke, Amanda Hagen, Tory M Blier, Pierre U |
author_facet |
Rodríguez, Enrique Radke, Amanda Hagen, Tory M Blier, Pierre U |
author_sort |
Rodríguez, Enrique |
title |
Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity |
title_short |
Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity |
title_full |
Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity |
title_fullStr |
Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity |
title_full_unstemmed |
Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity |
title_sort |
supercomplex organization of the electron transfer system in marine bivalves, a model of extreme longevity |
publisher |
Oxford University Press |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824617/ http://www.ncbi.nlm.nih.gov/pubmed/34871395 https://doi.org/10.1093/gerona/glab363 |
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Arctica islandica |
genre_facet |
Arctica islandica |
op_source |
J Gerontol A Biol Sci Med Sci |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824617/ http://www.ncbi.nlm.nih.gov/pubmed/34871395 http://dx.doi.org/10.1093/gerona/glab363 |
op_rights |
© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) |
op_doi |
https://doi.org/10.1093/gerona/glab363 |
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The Journals of Gerontology: Series A |
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77 |
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2 |
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283 |
op_container_end_page |
290 |
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1766353202245009408 |