Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals
Reef-building corals play an important role in marine ecosystems. However, owing to climate change, ocean acidification, and predation by invasive crown-of-thorns starfish, these corals are declining. As marine animals comprise polyps, reproduction by asexual budding is pivotal in scleractinian cora...
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ftpubmed:oai:pubmedcentral.nih.gov:8764167 2023-05-15T17:51:19+02:00 Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals Guo, Zhuojun Liao, Xin Chen, J.-Y. He, Chunpeng Lu, Zuhong 2022-01-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764167/ https://doi.org/10.3389/fphys.2021.759370 en eng Frontiers Media S.A. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764167/ http://dx.doi.org/10.3389/fphys.2021.759370 Copyright © 2022 Guo, Liao, Chen, He and Lu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. CC-BY Front Physiol Physiology Text 2022 ftpubmed https://doi.org/10.3389/fphys.2021.759370 2022-01-23T01:46:53Z Reef-building corals play an important role in marine ecosystems. However, owing to climate change, ocean acidification, and predation by invasive crown-of-thorns starfish, these corals are declining. As marine animals comprise polyps, reproduction by asexual budding is pivotal in scleractinian coral growth. The fibroblast growth factor (FGF) signaling pathway is essential in coral budding morphogenesis. Here, we sequenced the full-length transcriptomes of four common and frequently dominant reef-building corals and screened out the budding-related FGF and FGFR genes. Thereafter, three-dimensional (3D) models of FGF and FGFR proteins as well as FGF-FGFR binding models were reconstructed. Based on our findings, the FGF8-FGFR3 binding models in Pocillopora damicornis, Montipora capricornis, and Acropora muricata are typical receptor tyrosine kinase-signaling pathways that are similar to the Kringelchen (FGFR) in hydra. However, in P. verrucosa, FGF8 is not the FGFR3 ligand, which is found in other hydrozoan animals, and its FGFR3 must be activated by other tyrosine kinase-type ligands. Overall, this study provides background on the potentially budding propagation signaling pathway activated by the applications of biological agents in reef-building coral culture that could aid in the future restoration of coral reefs. Text Ocean acidification PubMed Central (PMC) Frontiers in Physiology 12 |
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Physiology |
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Physiology Guo, Zhuojun Liao, Xin Chen, J.-Y. He, Chunpeng Lu, Zuhong Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
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Physiology |
description |
Reef-building corals play an important role in marine ecosystems. However, owing to climate change, ocean acidification, and predation by invasive crown-of-thorns starfish, these corals are declining. As marine animals comprise polyps, reproduction by asexual budding is pivotal in scleractinian coral growth. The fibroblast growth factor (FGF) signaling pathway is essential in coral budding morphogenesis. Here, we sequenced the full-length transcriptomes of four common and frequently dominant reef-building corals and screened out the budding-related FGF and FGFR genes. Thereafter, three-dimensional (3D) models of FGF and FGFR proteins as well as FGF-FGFR binding models were reconstructed. Based on our findings, the FGF8-FGFR3 binding models in Pocillopora damicornis, Montipora capricornis, and Acropora muricata are typical receptor tyrosine kinase-signaling pathways that are similar to the Kringelchen (FGFR) in hydra. However, in P. verrucosa, FGF8 is not the FGFR3 ligand, which is found in other hydrozoan animals, and its FGFR3 must be activated by other tyrosine kinase-type ligands. Overall, this study provides background on the potentially budding propagation signaling pathway activated by the applications of biological agents in reef-building coral culture that could aid in the future restoration of coral reefs. |
format |
Text |
author |
Guo, Zhuojun Liao, Xin Chen, J.-Y. He, Chunpeng Lu, Zuhong |
author_facet |
Guo, Zhuojun Liao, Xin Chen, J.-Y. He, Chunpeng Lu, Zuhong |
author_sort |
Guo, Zhuojun |
title |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_short |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_full |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_fullStr |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_full_unstemmed |
Binding Pattern Reconstructions of FGF-FGFR Budding-Inducing Signaling in Reef-Building Corals |
title_sort |
binding pattern reconstructions of fgf-fgfr budding-inducing signaling in reef-building corals |
publisher |
Frontiers Media S.A. |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764167/ https://doi.org/10.3389/fphys.2021.759370 |
genre |
Ocean acidification |
genre_facet |
Ocean acidification |
op_source |
Front Physiol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764167/ http://dx.doi.org/10.3389/fphys.2021.759370 |
op_rights |
Copyright © 2022 Guo, Liao, Chen, He and Lu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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CC-BY |
op_doi |
https://doi.org/10.3389/fphys.2021.759370 |
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Frontiers in Physiology |
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12 |
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1766158420037074944 |