Organization of the Sleep-Related Neural Systems in the Brain of the Harbour Porpoise (Phocoena phocoena)

The present study provides the first systematic immunohistochemical neuroanatomical investigation of the systems involved in the control and regulation of sleep in an odontocete cetacean, the harbor porpoise (Phocoena phocoena). The odontocete cetaceans show an unusual form of mammalian sleep, with...

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Published in:Journal of Comparative Neurology
Main Authors: Dell, Leigh-Anne, Patzke, Nina, Spocter, Muhammad A., Siegel, Jerome M., Manger, Paul R.
Format: Text
Language:English
Published: 2016
Subjects:
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722820/
http://www.ncbi.nlm.nih.gov/pubmed/26588354
https://doi.org/10.1002/cne.23929
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spelling ftpubmed:oai:pubmedcentral.nih.gov:8722820 2023-05-15T16:33:28+02:00 Organization of the Sleep-Related Neural Systems in the Brain of the Harbour Porpoise (Phocoena phocoena) Dell, Leigh-Anne Patzke, Nina Spocter, Muhammad A. Siegel, Jerome M. Manger, Paul R. 2016-02-18 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722820/ http://www.ncbi.nlm.nih.gov/pubmed/26588354 https://doi.org/10.1002/cne.23929 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722820/ http://www.ncbi.nlm.nih.gov/pubmed/26588354 http://dx.doi.org/10.1002/cne.23929 J Comp Neurol Article Text 2016 ftpubmed https://doi.org/10.1002/cne.23929 2022-01-09T01:48:16Z The present study provides the first systematic immunohistochemical neuroanatomical investigation of the systems involved in the control and regulation of sleep in an odontocete cetacean, the harbor porpoise (Phocoena phocoena). The odontocete cetaceans show an unusual form of mammalian sleep, with unihemispheric slow waves, suppressed REM sleep, and continuous bodily movement. All the neural elements involved in sleep regulation and control found in bihemispheric sleeping mammals were present in the harbor porpoise, with no specific nuclei being absent, and no novel nuclei being present. This qualitative similarity of nuclear organization relates to the cholinergic, noradrenergic, serotonergic, and orexinergic systems and is extended to the γ-aminobutyric acid (GABA)ergic elements involved with these nuclei. Quantitative analysis of the cholinergic and noradrenergic nuclei of the pontine region revealed that in comparison with other mammals, the numbers of pontine cholinergic (126,776) and noradrenergic (122,878) neurons are markedly higher than in other large-brained bihemispheric sleeping mammals. The diminutive telencephalic commissures (anterior commissure, corpus callosum, and hippocampal commissure) along with an enlarged posterior commissure and supernumerary pontine cholinergic and noradrenergic neurons indicate that the control of unihemispheric slow-wave sleep is likely to be a function of interpontine competition, facilitated through the posterior commissure, in response to unilateral telencephalic input related to the drive for sleep. In addition, an expanded peripheral division of the dorsal raphe nuclear complex appears likely to play a role in the suppression of REM sleep in odontocete cetaceans. Thus, the current study provides several clues to the understanding of the neural control of the unusual sleep phenomenology present in odontocete cetaceans. Text Harbour porpoise Phocoena phocoena PubMed Central (PMC) Journal of Comparative Neurology 524 10 1999 2017
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Article
spellingShingle Article
Dell, Leigh-Anne
Patzke, Nina
Spocter, Muhammad A.
Siegel, Jerome M.
Manger, Paul R.
Organization of the Sleep-Related Neural Systems in the Brain of the Harbour Porpoise (Phocoena phocoena)
topic_facet Article
description The present study provides the first systematic immunohistochemical neuroanatomical investigation of the systems involved in the control and regulation of sleep in an odontocete cetacean, the harbor porpoise (Phocoena phocoena). The odontocete cetaceans show an unusual form of mammalian sleep, with unihemispheric slow waves, suppressed REM sleep, and continuous bodily movement. All the neural elements involved in sleep regulation and control found in bihemispheric sleeping mammals were present in the harbor porpoise, with no specific nuclei being absent, and no novel nuclei being present. This qualitative similarity of nuclear organization relates to the cholinergic, noradrenergic, serotonergic, and orexinergic systems and is extended to the γ-aminobutyric acid (GABA)ergic elements involved with these nuclei. Quantitative analysis of the cholinergic and noradrenergic nuclei of the pontine region revealed that in comparison with other mammals, the numbers of pontine cholinergic (126,776) and noradrenergic (122,878) neurons are markedly higher than in other large-brained bihemispheric sleeping mammals. The diminutive telencephalic commissures (anterior commissure, corpus callosum, and hippocampal commissure) along with an enlarged posterior commissure and supernumerary pontine cholinergic and noradrenergic neurons indicate that the control of unihemispheric slow-wave sleep is likely to be a function of interpontine competition, facilitated through the posterior commissure, in response to unilateral telencephalic input related to the drive for sleep. In addition, an expanded peripheral division of the dorsal raphe nuclear complex appears likely to play a role in the suppression of REM sleep in odontocete cetaceans. Thus, the current study provides several clues to the understanding of the neural control of the unusual sleep phenomenology present in odontocete cetaceans.
format Text
author Dell, Leigh-Anne
Patzke, Nina
Spocter, Muhammad A.
Siegel, Jerome M.
Manger, Paul R.
author_facet Dell, Leigh-Anne
Patzke, Nina
Spocter, Muhammad A.
Siegel, Jerome M.
Manger, Paul R.
author_sort Dell, Leigh-Anne
title Organization of the Sleep-Related Neural Systems in the Brain of the Harbour Porpoise (Phocoena phocoena)
title_short Organization of the Sleep-Related Neural Systems in the Brain of the Harbour Porpoise (Phocoena phocoena)
title_full Organization of the Sleep-Related Neural Systems in the Brain of the Harbour Porpoise (Phocoena phocoena)
title_fullStr Organization of the Sleep-Related Neural Systems in the Brain of the Harbour Porpoise (Phocoena phocoena)
title_full_unstemmed Organization of the Sleep-Related Neural Systems in the Brain of the Harbour Porpoise (Phocoena phocoena)
title_sort organization of the sleep-related neural systems in the brain of the harbour porpoise (phocoena phocoena)
publishDate 2016
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722820/
http://www.ncbi.nlm.nih.gov/pubmed/26588354
https://doi.org/10.1002/cne.23929
genre Harbour porpoise
Phocoena phocoena
genre_facet Harbour porpoise
Phocoena phocoena
op_source J Comp Neurol
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722820/
http://www.ncbi.nlm.nih.gov/pubmed/26588354
http://dx.doi.org/10.1002/cne.23929
op_doi https://doi.org/10.1002/cne.23929
container_title Journal of Comparative Neurology
container_volume 524
container_issue 10
container_start_page 1999
op_container_end_page 2017
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