Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection
Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins suc...
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ftpubmed:oai:pubmedcentral.nih.gov:8698471 2023-05-15T18:07:47+02:00 Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection Aguilera-Correa, John Jairo Fernández-López, Sara Cuñas-Figueroa, Iskra Dennisse Pérez-Rial, Sandra Alakomi, Hanna-Leena Nohynek, Liisa Oksman-Caldentey, Kirsi-Marja Salminen, Juha-Pekka Esteban, Jaime Cuadros, Juan Puupponen-Pimiä, Riitta Perez-Tanoira, Ramon Kinnari, Teemu J. 2021-12-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698471/ https://doi.org/10.3390/antibiotics10121481 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698471/ http://dx.doi.org/10.3390/antibiotics10121481 © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY Antibiotics (Basel) Article Text 2021 ftpubmed https://doi.org/10.3390/antibiotics10121481 2021-12-26T01:50:21Z Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in Rubus seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity. Text Rubus chamaemorus PubMed Central (PMC) Antibiotics 10 12 1481 |
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Article Aguilera-Correa, John Jairo Fernández-López, Sara Cuñas-Figueroa, Iskra Dennisse Pérez-Rial, Sandra Alakomi, Hanna-Leena Nohynek, Liisa Oksman-Caldentey, Kirsi-Marja Salminen, Juha-Pekka Esteban, Jaime Cuadros, Juan Puupponen-Pimiä, Riitta Perez-Tanoira, Ramon Kinnari, Teemu J. Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
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Article |
description |
Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in Rubus seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity. |
format |
Text |
author |
Aguilera-Correa, John Jairo Fernández-López, Sara Cuñas-Figueroa, Iskra Dennisse Pérez-Rial, Sandra Alakomi, Hanna-Leena Nohynek, Liisa Oksman-Caldentey, Kirsi-Marja Salminen, Juha-Pekka Esteban, Jaime Cuadros, Juan Puupponen-Pimiä, Riitta Perez-Tanoira, Ramon Kinnari, Teemu J. |
author_facet |
Aguilera-Correa, John Jairo Fernández-López, Sara Cuñas-Figueroa, Iskra Dennisse Pérez-Rial, Sandra Alakomi, Hanna-Leena Nohynek, Liisa Oksman-Caldentey, Kirsi-Marja Salminen, Juha-Pekka Esteban, Jaime Cuadros, Juan Puupponen-Pimiä, Riitta Perez-Tanoira, Ramon Kinnari, Teemu J. |
author_sort |
Aguilera-Correa, John Jairo |
title |
Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_short |
Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_full |
Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_fullStr |
Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_full_unstemmed |
Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection |
title_sort |
sanguiin h-6 fractionated from cloudberry (rubus chamaemorus) seeds can prevent the methicillin-resistant staphylococcus aureus biofilm development during wound infection |
publisher |
MDPI |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698471/ https://doi.org/10.3390/antibiotics10121481 |
genre |
Rubus chamaemorus |
genre_facet |
Rubus chamaemorus |
op_source |
Antibiotics (Basel) |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698471/ http://dx.doi.org/10.3390/antibiotics10121481 |
op_rights |
© 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/antibiotics10121481 |
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Antibiotics |
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10 |
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12 |
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1481 |
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1766180011657658368 |