Biosynthetic potential of uncultured Antarctic soil bacteria revealed through long-read metagenomic sequencing

• Published in: The ISME Journal
• Main Authors: Waschulin, Valentin, Borsetto, Chiara, James, Robert, Newsham, Kevin K., Donadio, Stefano, Corre, Christophe, Wellington, Elizabeth
• Format: Text
• Language: English
• Published: Nature Publishing Group UK 2021
• Subjects: Article; Antarctic; Mars Oasis; Antarc*; Antarctica
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692599/; http://www.ncbi.nlm.nih.gov/pubmed/34253854; https://doi.org/10.1038/s41396-021-01052-3

The growing problem of antibiotic resistance has led to the exploration of uncultured bacteria as potential sources of new antimicrobials. PCR amplicon analyses and short-read sequencing studies of samples from different environments have reported evidence of high biosynthetic gene cluster (BGC) div...