Marine mollusc extracts—Potential source of SARS‐CoV‐2 antivirals
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a novel human coronavirus and the causative agent of coronavirus disease 2019 (Covid‐19). There is an urgent need for effective antivirals to treat current Covid‐19 cases and protect those unable to be vaccinated against SARS‐CoV‐2. Mar...
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ftpubmed:oai:pubmedcentral.nih.gov:8646538 2023-05-15T15:58:36+02:00 Marine mollusc extracts—Potential source of SARS‐CoV‐2 antivirals Pedler, Rebecca L. Speck, Peter G. 2021-11-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646538/ http://www.ncbi.nlm.nih.gov/pubmed/34726308 https://doi.org/10.1002/rmv.2310 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646538/ http://www.ncbi.nlm.nih.gov/pubmed/34726308 http://dx.doi.org/10.1002/rmv.2310 © 2021 John Wiley & Sons Ltd. This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency. Rev Med Virol Review Text 2021 ftpubmed https://doi.org/10.1002/rmv.2310 2021-12-12T01:41:43Z Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a novel human coronavirus and the causative agent of coronavirus disease 2019 (Covid‐19). There is an urgent need for effective antivirals to treat current Covid‐19 cases and protect those unable to be vaccinated against SARS‐CoV‐2. Marine molluscs live in an environment containing high virus densities (>10(7) virus particles per ml), and there are an estimated 100,000 species in the phylum Mollusca, demonstrating the success of their innate immune system. Mollusc‐derived antivirals are yet to be used clinically despite the activity of many extracts, including against human viruses, being demonstrated in vitro. Hemolymph of the Pacific oyster (Crassostrea gigas) has in vitro antiviral activity against herpes simplex virus and human adenovirus, while antiviral action against SARS‐CoV‐2 has been proposed by in silico studies. Such evidence suggests that molluscs, and in particular C. gigas hemolymph, may represent a source of antivirals for human coronaviruses. Text Crassostrea gigas Pacific oyster PubMed Central (PMC) Pacific Reviews in Medical Virology |
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Review Pedler, Rebecca L. Speck, Peter G. Marine mollusc extracts—Potential source of SARS‐CoV‐2 antivirals |
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Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a novel human coronavirus and the causative agent of coronavirus disease 2019 (Covid‐19). There is an urgent need for effective antivirals to treat current Covid‐19 cases and protect those unable to be vaccinated against SARS‐CoV‐2. Marine molluscs live in an environment containing high virus densities (>10(7) virus particles per ml), and there are an estimated 100,000 species in the phylum Mollusca, demonstrating the success of their innate immune system. Mollusc‐derived antivirals are yet to be used clinically despite the activity of many extracts, including against human viruses, being demonstrated in vitro. Hemolymph of the Pacific oyster (Crassostrea gigas) has in vitro antiviral activity against herpes simplex virus and human adenovirus, while antiviral action against SARS‐CoV‐2 has been proposed by in silico studies. Such evidence suggests that molluscs, and in particular C. gigas hemolymph, may represent a source of antivirals for human coronaviruses. |
format |
Text |
author |
Pedler, Rebecca L. Speck, Peter G. |
author_facet |
Pedler, Rebecca L. Speck, Peter G. |
author_sort |
Pedler, Rebecca L. |
title |
Marine mollusc extracts—Potential source of SARS‐CoV‐2 antivirals |
title_short |
Marine mollusc extracts—Potential source of SARS‐CoV‐2 antivirals |
title_full |
Marine mollusc extracts—Potential source of SARS‐CoV‐2 antivirals |
title_fullStr |
Marine mollusc extracts—Potential source of SARS‐CoV‐2 antivirals |
title_full_unstemmed |
Marine mollusc extracts—Potential source of SARS‐CoV‐2 antivirals |
title_sort |
marine mollusc extracts—potential source of sars‐cov‐2 antivirals |
publisher |
John Wiley and Sons Inc. |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646538/ http://www.ncbi.nlm.nih.gov/pubmed/34726308 https://doi.org/10.1002/rmv.2310 |
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Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Rev Med Virol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646538/ http://www.ncbi.nlm.nih.gov/pubmed/34726308 http://dx.doi.org/10.1002/rmv.2310 |
op_rights |
© 2021 John Wiley & Sons Ltd. This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency. |
op_doi |
https://doi.org/10.1002/rmv.2310 |
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Reviews in Medical Virology |
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