A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis
In the present study, the modulation of the transcriptional immune response (microarray analysis) in the head kidney (HK) of the anadromous fish Atlantic salmon (Salmo salar) fed a diet supplemented with an olive fruit extract (AQUOLIVE(®)) was evaluated. At the end of the trial (133 days), in order...
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ftpubmed:oai:pubmedcentral.nih.gov:8633542 2023-05-15T15:30:51+02:00 A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis Salomón, Ricardo Furones, M. Dolors Reyes-López, Felipe E. Tort, Lluis Firmino, Joana P. Esteban, M. Angeles Espinosa Ruíz, Cristóbal Quintela, José C. Pinilla-Rosas, José M. Vallejos-Vidal, Eva Gisbert, Enric 2021-11-12 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633542/ https://doi.org/10.3389/fimmu.2021.737601 en eng Frontiers Media S.A. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633542/ http://dx.doi.org/10.3389/fimmu.2021.737601 Copyright © 2021 Salomón, Furones, Reyes-López, Tort, Firmino, Esteban, Espinosa Ruíz, Quintela, Pinilla-Rosas, Vallejos-Vidal and Gisbert https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. CC-BY Front Immunol Immunology Text 2021 ftpubmed https://doi.org/10.3389/fimmu.2021.737601 2021-12-05T02:02:51Z In the present study, the modulation of the transcriptional immune response (microarray analysis) in the head kidney (HK) of the anadromous fish Atlantic salmon (Salmo salar) fed a diet supplemented with an olive fruit extract (AQUOLIVE(®)) was evaluated. At the end of the trial (133 days), in order to investigate the immunomodulatory properties of the phytogenic tested against a bacterial infection, an in vivo challenge with Aeromonas salmonicida was performed. A total number of 1,027 differentially expressed genes (DEGs) (805 up- and 222 downregulated) were found when comparing the transcriptomic profiling of the HK from fish fed the control and AQUOLIVE(®) diets. The HK transcripteractome revealed an expression profile that mainly favored biological processes related to immunity. Particularly, the signaling of i-kappa B kinase/NF-kappa and the activation of leukocytes, such as granulocytes and neutrophils degranulation, were suggested to be the primary actors of the innate immune response promoted by the tested functional feed additive in the HK. Moreover, the bacterial challenge with A. salmonicida that lasted 12 days showed that the cumulative survival was higher in fish fed the AQUOLIVE(®) diet (96.9 ± 6.4%) than the control group (60.7 ± 13.5%). These results indicate that the dietary supplementation of AQUOLIVE(®) at the level of 0.15% enhanced the systemic immune response and reduced the A. salmonicida cumulative mortality in Atlantic salmon smolts. Text Atlantic salmon Salmo salar PubMed Central (PMC) Frontiers in Immunology 12 |
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English |
topic |
Immunology |
spellingShingle |
Immunology Salomón, Ricardo Furones, M. Dolors Reyes-López, Felipe E. Tort, Lluis Firmino, Joana P. Esteban, M. Angeles Espinosa Ruíz, Cristóbal Quintela, José C. Pinilla-Rosas, José M. Vallejos-Vidal, Eva Gisbert, Enric A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis |
topic_facet |
Immunology |
description |
In the present study, the modulation of the transcriptional immune response (microarray analysis) in the head kidney (HK) of the anadromous fish Atlantic salmon (Salmo salar) fed a diet supplemented with an olive fruit extract (AQUOLIVE(®)) was evaluated. At the end of the trial (133 days), in order to investigate the immunomodulatory properties of the phytogenic tested against a bacterial infection, an in vivo challenge with Aeromonas salmonicida was performed. A total number of 1,027 differentially expressed genes (DEGs) (805 up- and 222 downregulated) were found when comparing the transcriptomic profiling of the HK from fish fed the control and AQUOLIVE(®) diets. The HK transcripteractome revealed an expression profile that mainly favored biological processes related to immunity. Particularly, the signaling of i-kappa B kinase/NF-kappa and the activation of leukocytes, such as granulocytes and neutrophils degranulation, were suggested to be the primary actors of the innate immune response promoted by the tested functional feed additive in the HK. Moreover, the bacterial challenge with A. salmonicida that lasted 12 days showed that the cumulative survival was higher in fish fed the AQUOLIVE(®) diet (96.9 ± 6.4%) than the control group (60.7 ± 13.5%). These results indicate that the dietary supplementation of AQUOLIVE(®) at the level of 0.15% enhanced the systemic immune response and reduced the A. salmonicida cumulative mortality in Atlantic salmon smolts. |
format |
Text |
author |
Salomón, Ricardo Furones, M. Dolors Reyes-López, Felipe E. Tort, Lluis Firmino, Joana P. Esteban, M. Angeles Espinosa Ruíz, Cristóbal Quintela, José C. Pinilla-Rosas, José M. Vallejos-Vidal, Eva Gisbert, Enric |
author_facet |
Salomón, Ricardo Furones, M. Dolors Reyes-López, Felipe E. Tort, Lluis Firmino, Joana P. Esteban, M. Angeles Espinosa Ruíz, Cristóbal Quintela, José C. Pinilla-Rosas, José M. Vallejos-Vidal, Eva Gisbert, Enric |
author_sort |
Salomón, Ricardo |
title |
A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis |
title_short |
A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis |
title_full |
A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis |
title_fullStr |
A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis |
title_full_unstemmed |
A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis |
title_sort |
bioactive extract rich in triterpenic acid and polyphenols from olea europaea promotes systemic immunity and protects atlantic salmon smolts against furunculosis |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633542/ https://doi.org/10.3389/fimmu.2021.737601 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Front Immunol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633542/ http://dx.doi.org/10.3389/fimmu.2021.737601 |
op_rights |
Copyright © 2021 Salomón, Furones, Reyes-López, Tort, Firmino, Esteban, Espinosa Ruíz, Quintela, Pinilla-Rosas, Vallejos-Vidal and Gisbert https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fimmu.2021.737601 |
container_title |
Frontiers in Immunology |
container_volume |
12 |
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1766361324796772352 |