Identification and genome analysis of a novel picornavirus from captive belugas (Delphinapterus leucas) in China
The discovery of new viruses is important for predicting their potential threats to the health of humans and other animals. A novel picornavirus was identified from oral, throat, and anal swab samples collected from belugas (Delphinapterus leucas), from Dalian Sun Asia Tourism Holding Co., China, be...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549006/ http://www.ncbi.nlm.nih.gov/pubmed/34697355 https://doi.org/10.1038/s41598-021-00605-y |
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ftpubmed:oai:pubmedcentral.nih.gov:8549006 2023-05-15T15:41:59+02:00 Identification and genome analysis of a novel picornavirus from captive belugas (Delphinapterus leucas) in China Wang, Gaoyu Huang, Yi Zhang, Weijia Peng, Ruoyan Luo, Jun Liu, Sisi Bai, Shijie Hu, Xiaoyuan Wu, Zhiqiang Yang, Fan Shen, Shu Zhang, Yun Tang, Chuanning Cui, Xiuji Niu, Lina Lu, Gang Li, Songhai Deng, Fei Zhang, Peijun Du, Jiang Yin, Feifei 2021-10-25 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549006/ http://www.ncbi.nlm.nih.gov/pubmed/34697355 https://doi.org/10.1038/s41598-021-00605-y en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549006/ http://www.ncbi.nlm.nih.gov/pubmed/34697355 http://dx.doi.org/10.1038/s41598-021-00605-y © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . CC-BY Sci Rep Article Text 2021 ftpubmed https://doi.org/10.1038/s41598-021-00605-y 2021-10-31T01:02:08Z The discovery of new viruses is important for predicting their potential threats to the health of humans and other animals. A novel picornavirus was identified from oral, throat, and anal swab samples collected from belugas (Delphinapterus leucas), from Dalian Sun Asia Tourism Holding Co., China, between January and December 2018, using a metagenomics approach. The genome of this novel PicoV-HMU-1 strain was 8197 nucleotides (nt) in length, with a open reading frame (from 1091 to 8074 nt) that encoded a polyprotein precursor of 2328 amino acids. Moreover, the genomic length and GC content of PicoV-HMU-1 were within the ranges found in other picornaviruses, and the genome organization was also similar. Nevertheless, PicoV-HMU-1 had a lower amino acid identity and distinct host species compared with other members of the Picornaviridae family. Phylogenetic trees were constructed based on the P1 and 3D amino acid sequences of PicoV-HMU-1 along with representative members of the Picornaviridae family, which showed that PicoV-HMU-1 was related to unclassified bat picornaviruses groups. These findings suggest that the PicoV-HMU-1 strain represents a potentially novel genus of picornavirus. These data can enhance our understanding of the picornavirus genetic diversity and evolution. Text Beluga* Delphinapterus leucas PubMed Central (PMC) Scientific Reports 11 1 |
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Article Wang, Gaoyu Huang, Yi Zhang, Weijia Peng, Ruoyan Luo, Jun Liu, Sisi Bai, Shijie Hu, Xiaoyuan Wu, Zhiqiang Yang, Fan Shen, Shu Zhang, Yun Tang, Chuanning Cui, Xiuji Niu, Lina Lu, Gang Li, Songhai Deng, Fei Zhang, Peijun Du, Jiang Yin, Feifei Identification and genome analysis of a novel picornavirus from captive belugas (Delphinapterus leucas) in China |
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The discovery of new viruses is important for predicting their potential threats to the health of humans and other animals. A novel picornavirus was identified from oral, throat, and anal swab samples collected from belugas (Delphinapterus leucas), from Dalian Sun Asia Tourism Holding Co., China, between January and December 2018, using a metagenomics approach. The genome of this novel PicoV-HMU-1 strain was 8197 nucleotides (nt) in length, with a open reading frame (from 1091 to 8074 nt) that encoded a polyprotein precursor of 2328 amino acids. Moreover, the genomic length and GC content of PicoV-HMU-1 were within the ranges found in other picornaviruses, and the genome organization was also similar. Nevertheless, PicoV-HMU-1 had a lower amino acid identity and distinct host species compared with other members of the Picornaviridae family. Phylogenetic trees were constructed based on the P1 and 3D amino acid sequences of PicoV-HMU-1 along with representative members of the Picornaviridae family, which showed that PicoV-HMU-1 was related to unclassified bat picornaviruses groups. These findings suggest that the PicoV-HMU-1 strain represents a potentially novel genus of picornavirus. These data can enhance our understanding of the picornavirus genetic diversity and evolution. |
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Text |
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Wang, Gaoyu Huang, Yi Zhang, Weijia Peng, Ruoyan Luo, Jun Liu, Sisi Bai, Shijie Hu, Xiaoyuan Wu, Zhiqiang Yang, Fan Shen, Shu Zhang, Yun Tang, Chuanning Cui, Xiuji Niu, Lina Lu, Gang Li, Songhai Deng, Fei Zhang, Peijun Du, Jiang Yin, Feifei |
author_facet |
Wang, Gaoyu Huang, Yi Zhang, Weijia Peng, Ruoyan Luo, Jun Liu, Sisi Bai, Shijie Hu, Xiaoyuan Wu, Zhiqiang Yang, Fan Shen, Shu Zhang, Yun Tang, Chuanning Cui, Xiuji Niu, Lina Lu, Gang Li, Songhai Deng, Fei Zhang, Peijun Du, Jiang Yin, Feifei |
author_sort |
Wang, Gaoyu |
title |
Identification and genome analysis of a novel picornavirus from captive belugas (Delphinapterus leucas) in China |
title_short |
Identification and genome analysis of a novel picornavirus from captive belugas (Delphinapterus leucas) in China |
title_full |
Identification and genome analysis of a novel picornavirus from captive belugas (Delphinapterus leucas) in China |
title_fullStr |
Identification and genome analysis of a novel picornavirus from captive belugas (Delphinapterus leucas) in China |
title_full_unstemmed |
Identification and genome analysis of a novel picornavirus from captive belugas (Delphinapterus leucas) in China |
title_sort |
identification and genome analysis of a novel picornavirus from captive belugas (delphinapterus leucas) in china |
publisher |
Nature Publishing Group UK |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549006/ http://www.ncbi.nlm.nih.gov/pubmed/34697355 https://doi.org/10.1038/s41598-021-00605-y |
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Beluga* Delphinapterus leucas |
genre_facet |
Beluga* Delphinapterus leucas |
op_source |
Sci Rep |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549006/ http://www.ncbi.nlm.nih.gov/pubmed/34697355 http://dx.doi.org/10.1038/s41598-021-00605-y |
op_rights |
© The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
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CC-BY |
op_doi |
https://doi.org/10.1038/s41598-021-00605-y |
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