Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants
Although previous studies have highlighted the association between physical activity and lower extremity function (LEF) in elderly individuals, the mechanisms underlying this relationship remain debated. Our recent work has recognized the utility of nonlinear trimodal regression analysis (NTRA) para...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505499/ http://www.ncbi.nlm.nih.gov/pubmed/34635746 https://doi.org/10.1038/s41598-021-99699-7 |
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ftpubmed:oai:pubmedcentral.nih.gov:8505499 2023-05-15T18:06:57+02:00 Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants Edmunds, Kyle J. Okonkwo, Ozioma C. Sigurdsson, Sigurdur Lose, Sarah R. Gudnason, Vilmundur Carraro, Ugo Gargiulo, Paolo 2021-10-11 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505499/ http://www.ncbi.nlm.nih.gov/pubmed/34635746 https://doi.org/10.1038/s41598-021-99699-7 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505499/ http://www.ncbi.nlm.nih.gov/pubmed/34635746 http://dx.doi.org/10.1038/s41598-021-99699-7 © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . CC-BY Sci Rep Article Text 2021 ftpubmed https://doi.org/10.1038/s41598-021-99699-7 2021-10-17T00:36:48Z Although previous studies have highlighted the association between physical activity and lower extremity function (LEF) in elderly individuals, the mechanisms underlying this relationship remain debated. Our recent work has recognized the utility of nonlinear trimodal regression analysis (NTRA) parameters in characterizing changes in soft tissue radiodensity as a quantitative construct for sarcopenia in the longitudinal, population-based cohort of the AGES-Reykjavík study. For the present work, we assembled a series of prospective multivariate regression models to interrogate whether NTRA parameters mediate the 5-year longitudinal relationship between physical activity and LEF in AGES-Reykjavík participants. Healthy elderly volunteers from the AGES-Reykjavík cohort underwent mid-thigh X-ray CT scans along with a four-part battery of LEF tasks: normal gait speed, fastest-comfortable gait speed, isometric leg strength, and timed up-and-go. These data were recorded at two study timepoints which were separated by approximately 5 years: AGES-I (n = 3157) and AGES-II (n = 3098). Participants in AGES-I were likewise administered a survey to approximate their weekly frequency of engaging in moderate-to-vigorous physical activity (PA(AGES-I)). Using a multivariate mediation analysis framework, linear regression models were assembled to test whether NTRA parameters mediated the longitudinal relationship between PA(AGES-I) and LEF(AGES-II); all models were covariate-adjusted for age, sex, BMI, and baseline LEF, and results were corrected for multiple statistical comparisons. Our first series of models confirmed that all four LEF tasks were significantly related to PA(AGES-I); next, modelling the relationship between PA(AGES-I) and NTRA(AGES-II) identified muscle amplitude (N(m)) and location (μ(m)) as potential mediators of LEF to test. Finally, adding these two parameters into our PA(AGES-I) → LEF(AGES-II) models attenuated the prior effect of PA(AGES-I); bootstrapping confirmed N(m) and μ(m) as significant partial ... Text Reykjavík Reykjavík PubMed Central (PMC) Reykjavík Izvestiya TINRO 200 2 486 495 |
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Article Edmunds, Kyle J. Okonkwo, Ozioma C. Sigurdsson, Sigurdur Lose, Sarah R. Gudnason, Vilmundur Carraro, Ugo Gargiulo, Paolo Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants |
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Article |
description |
Although previous studies have highlighted the association between physical activity and lower extremity function (LEF) in elderly individuals, the mechanisms underlying this relationship remain debated. Our recent work has recognized the utility of nonlinear trimodal regression analysis (NTRA) parameters in characterizing changes in soft tissue radiodensity as a quantitative construct for sarcopenia in the longitudinal, population-based cohort of the AGES-Reykjavík study. For the present work, we assembled a series of prospective multivariate regression models to interrogate whether NTRA parameters mediate the 5-year longitudinal relationship between physical activity and LEF in AGES-Reykjavík participants. Healthy elderly volunteers from the AGES-Reykjavík cohort underwent mid-thigh X-ray CT scans along with a four-part battery of LEF tasks: normal gait speed, fastest-comfortable gait speed, isometric leg strength, and timed up-and-go. These data were recorded at two study timepoints which were separated by approximately 5 years: AGES-I (n = 3157) and AGES-II (n = 3098). Participants in AGES-I were likewise administered a survey to approximate their weekly frequency of engaging in moderate-to-vigorous physical activity (PA(AGES-I)). Using a multivariate mediation analysis framework, linear regression models were assembled to test whether NTRA parameters mediated the longitudinal relationship between PA(AGES-I) and LEF(AGES-II); all models were covariate-adjusted for age, sex, BMI, and baseline LEF, and results were corrected for multiple statistical comparisons. Our first series of models confirmed that all four LEF tasks were significantly related to PA(AGES-I); next, modelling the relationship between PA(AGES-I) and NTRA(AGES-II) identified muscle amplitude (N(m)) and location (μ(m)) as potential mediators of LEF to test. Finally, adding these two parameters into our PA(AGES-I) → LEF(AGES-II) models attenuated the prior effect of PA(AGES-I); bootstrapping confirmed N(m) and μ(m) as significant partial ... |
format |
Text |
author |
Edmunds, Kyle J. Okonkwo, Ozioma C. Sigurdsson, Sigurdur Lose, Sarah R. Gudnason, Vilmundur Carraro, Ugo Gargiulo, Paolo |
author_facet |
Edmunds, Kyle J. Okonkwo, Ozioma C. Sigurdsson, Sigurdur Lose, Sarah R. Gudnason, Vilmundur Carraro, Ugo Gargiulo, Paolo |
author_sort |
Edmunds, Kyle J. |
title |
Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants |
title_short |
Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants |
title_full |
Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants |
title_fullStr |
Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants |
title_full_unstemmed |
Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants |
title_sort |
soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in ages-reykjavík participants |
publisher |
Nature Publishing Group UK |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505499/ http://www.ncbi.nlm.nih.gov/pubmed/34635746 https://doi.org/10.1038/s41598-021-99699-7 |
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Reykjavík Reykjavík |
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Reykjavík Reykjavík |
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Sci Rep |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505499/ http://www.ncbi.nlm.nih.gov/pubmed/34635746 http://dx.doi.org/10.1038/s41598-021-99699-7 |
op_rights |
© The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
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https://doi.org/10.1038/s41598-021-99699-7 |
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