Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries
SIMPLE SUMMARY: The treatment of osteosarcoma and Ewing sarcoma, the two major types of malignant bone tumors in children, has progressed considerably during the last decades, with more patients becoming long-term survivors. This improvement has resulted in an increasing number of patients with long...
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ftpubmed:oai:pubmedcentral.nih.gov:8467516 2023-05-15T16:52:33+02:00 Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries Pedersen, Camilla Rechnitzer, Catherine Andersen, Elisabeth Anne Wreford Kenborg, Line Norsker, Filippa Nyboe Bautz, Andrea Baad-Hansen, Thomas Tryggvadottir, Laufey Madanat-Harjuoja, Laura-Maria Holmqvist, Anna Sällfors Hjorth, Lars Hasle, Henrik Winther, Jeanette Falck 2021-09-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467516/ http://www.ncbi.nlm.nih.gov/pubmed/34572734 https://doi.org/10.3390/cancers13184505 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467516/ http://www.ncbi.nlm.nih.gov/pubmed/34572734 http://dx.doi.org/10.3390/cancers13184505 © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY Cancers (Basel) Article Text 2021 ftpubmed https://doi.org/10.3390/cancers13184505 2021-10-03T00:58:43Z SIMPLE SUMMARY: The treatment of osteosarcoma and Ewing sarcoma, the two major types of malignant bone tumors in children, has progressed considerably during the last decades, with more patients becoming long-term survivors. This improvement has resulted in an increasing number of patients with long-term adverse health consequences from the life-saving treatment. The aim of this study was to provide a detailed, comprehensive overview of somatic diseases that require hospitalization in long-term survivors of osteosarcoma and Ewing sarcoma. This study contributes new insights into the risk of somatic late effects in survivors of osteosarcoma and Ewing sarcoma which are urgently requested by pediatric oncologists, researchers, and by survivors and their families. The study provides an essential basis for the development of preventive intervention strategies and for optimal patient counseling and follow-up care, which all contribute to improving the health and quality of life in survivors. ABSTRACT: Survivors of malignant bone tumors in childhood are at risk of long-term adverse health effects. We comprehensively reviewed cases of somatic diseases that required a hospital contact in survivors of osteosarcoma and Ewing sarcoma. In a population-based cohort study, 620 five-year survivors of osteosarcoma (n = 440) or Ewing sarcoma (n = 180), diagnosed before the age of 20 years in Denmark, Finland, Iceland, and Sweden during 1943–2008, were followed in the national hospital registers. Overall rates of hospital contacts for any somatic disease and for 12 main diagnostic groups and 120 specific disease categories were compared with those in a matched comparison cohort (n = 3049) randomly selected from the national population registers. The rate of hospital contact for any somatic disease was 80% higher in survivors of malignant bone tumors than in comparisons and remained elevated up to 30 years after diagnosis. The rate of hospital contacts was higher after Ewing sarcoma (rate ratio (RR) 2.24; 95% confidence interval ... Text Iceland PubMed Central (PMC) Ewing ENVELOPE(-61.257,-61.257,-69.924,-69.924) Cancers 13 18 4505 |
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Article Pedersen, Camilla Rechnitzer, Catherine Andersen, Elisabeth Anne Wreford Kenborg, Line Norsker, Filippa Nyboe Bautz, Andrea Baad-Hansen, Thomas Tryggvadottir, Laufey Madanat-Harjuoja, Laura-Maria Holmqvist, Anna Sällfors Hjorth, Lars Hasle, Henrik Winther, Jeanette Falck Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries |
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description |
SIMPLE SUMMARY: The treatment of osteosarcoma and Ewing sarcoma, the two major types of malignant bone tumors in children, has progressed considerably during the last decades, with more patients becoming long-term survivors. This improvement has resulted in an increasing number of patients with long-term adverse health consequences from the life-saving treatment. The aim of this study was to provide a detailed, comprehensive overview of somatic diseases that require hospitalization in long-term survivors of osteosarcoma and Ewing sarcoma. This study contributes new insights into the risk of somatic late effects in survivors of osteosarcoma and Ewing sarcoma which are urgently requested by pediatric oncologists, researchers, and by survivors and their families. The study provides an essential basis for the development of preventive intervention strategies and for optimal patient counseling and follow-up care, which all contribute to improving the health and quality of life in survivors. ABSTRACT: Survivors of malignant bone tumors in childhood are at risk of long-term adverse health effects. We comprehensively reviewed cases of somatic diseases that required a hospital contact in survivors of osteosarcoma and Ewing sarcoma. In a population-based cohort study, 620 five-year survivors of osteosarcoma (n = 440) or Ewing sarcoma (n = 180), diagnosed before the age of 20 years in Denmark, Finland, Iceland, and Sweden during 1943–2008, were followed in the national hospital registers. Overall rates of hospital contacts for any somatic disease and for 12 main diagnostic groups and 120 specific disease categories were compared with those in a matched comparison cohort (n = 3049) randomly selected from the national population registers. The rate of hospital contact for any somatic disease was 80% higher in survivors of malignant bone tumors than in comparisons and remained elevated up to 30 years after diagnosis. The rate of hospital contacts was higher after Ewing sarcoma (rate ratio (RR) 2.24; 95% confidence interval ... |
format |
Text |
author |
Pedersen, Camilla Rechnitzer, Catherine Andersen, Elisabeth Anne Wreford Kenborg, Line Norsker, Filippa Nyboe Bautz, Andrea Baad-Hansen, Thomas Tryggvadottir, Laufey Madanat-Harjuoja, Laura-Maria Holmqvist, Anna Sällfors Hjorth, Lars Hasle, Henrik Winther, Jeanette Falck |
author_facet |
Pedersen, Camilla Rechnitzer, Catherine Andersen, Elisabeth Anne Wreford Kenborg, Line Norsker, Filippa Nyboe Bautz, Andrea Baad-Hansen, Thomas Tryggvadottir, Laufey Madanat-Harjuoja, Laura-Maria Holmqvist, Anna Sällfors Hjorth, Lars Hasle, Henrik Winther, Jeanette Falck |
author_sort |
Pedersen, Camilla |
title |
Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries |
title_short |
Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries |
title_full |
Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries |
title_fullStr |
Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries |
title_full_unstemmed |
Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries |
title_sort |
somatic disease in survivors of childhood malignant bone tumors in the nordic countries |
publisher |
MDPI |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467516/ http://www.ncbi.nlm.nih.gov/pubmed/34572734 https://doi.org/10.3390/cancers13184505 |
long_lat |
ENVELOPE(-61.257,-61.257,-69.924,-69.924) |
geographic |
Ewing |
geographic_facet |
Ewing |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Cancers (Basel) |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467516/ http://www.ncbi.nlm.nih.gov/pubmed/34572734 http://dx.doi.org/10.3390/cancers13184505 |
op_rights |
© 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/cancers13184505 |
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Cancers |
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13 |
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18 |
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4505 |
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1766042873098141696 |