Hibernating brown bears are protected against atherogenic dyslipidemia
To investigate mechanisms by which hibernators avoid atherogenic hyperlipidemia during hibernation, we assessed lipoprotein and cholesterol metabolisms of free-ranging Scandinavian brown bears (Ursus arctos). In winter- and summer-captured bears, we measured lipoprotein sizes and sub-classes, trigly...
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ftpubmed:oai:pubmedcentral.nih.gov:8455566 2023-05-15T18:42:03+02:00 Hibernating brown bears are protected against atherogenic dyslipidemia Giroud, Sylvain Chery, Isabelle Arrivé, Mathilde Prost, Michel Zumsteg, Julie Heintz, Dimitri Evans, Alina L. Gauquelin-Koch, Guillemette Arnemo, Jon M. Swenson, Jon E. Lefai, Etienne Bertile, Fabrice Simon, Chantal Blanc, Stéphane 2021-09-21 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455566/ https://doi.org/10.1038/s41598-021-98085-7 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455566/ http://dx.doi.org/10.1038/s41598-021-98085-7 © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . CC-BY Sci Rep Article Text 2021 ftpubmed https://doi.org/10.1038/s41598-021-98085-7 2021-09-26T00:40:59Z To investigate mechanisms by which hibernators avoid atherogenic hyperlipidemia during hibernation, we assessed lipoprotein and cholesterol metabolisms of free-ranging Scandinavian brown bears (Ursus arctos). In winter- and summer-captured bears, we measured lipoprotein sizes and sub-classes, triglyceride-related plasma-enzyme activities, and muscle lipid composition along with plasma-levels of antioxidant capacities and inflammatory markers. Although hibernating bears increased nearly all lipid levels, a 36%-higher cholesteryl-ester transfer-protein activity allowed to stabilize lipid composition of high-density lipoproteins (HDL). Levels of inflammatory metabolites, i.e., 7-ketocholesterol and 11ß-prostaglandin F2α, declined in winter and correlated inversely with cardioprotective HDL2b-proportions and HDL-sizes that increased during hibernation. Lower muscle-cholesterol concentrations and lecithin-cholesterol acyltransferase activity in winter suggest that hibernating bears tightly controlled peripheral-cholesterol synthesis and/or release. Finally, greater plasma-antioxidant capacities prevented excessive lipid-specific oxidative damages in plasma and muscles of hibernating bears. Hence, the brown bear manages large lipid fluxes during hibernation, without developing adverse atherogenic effects that occur in humans and non-hibernators. Text Ursus arctos PubMed Central (PMC) Scientific Reports 11 1 |
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Article Giroud, Sylvain Chery, Isabelle Arrivé, Mathilde Prost, Michel Zumsteg, Julie Heintz, Dimitri Evans, Alina L. Gauquelin-Koch, Guillemette Arnemo, Jon M. Swenson, Jon E. Lefai, Etienne Bertile, Fabrice Simon, Chantal Blanc, Stéphane Hibernating brown bears are protected against atherogenic dyslipidemia |
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Article |
description |
To investigate mechanisms by which hibernators avoid atherogenic hyperlipidemia during hibernation, we assessed lipoprotein and cholesterol metabolisms of free-ranging Scandinavian brown bears (Ursus arctos). In winter- and summer-captured bears, we measured lipoprotein sizes and sub-classes, triglyceride-related plasma-enzyme activities, and muscle lipid composition along with plasma-levels of antioxidant capacities and inflammatory markers. Although hibernating bears increased nearly all lipid levels, a 36%-higher cholesteryl-ester transfer-protein activity allowed to stabilize lipid composition of high-density lipoproteins (HDL). Levels of inflammatory metabolites, i.e., 7-ketocholesterol and 11ß-prostaglandin F2α, declined in winter and correlated inversely with cardioprotective HDL2b-proportions and HDL-sizes that increased during hibernation. Lower muscle-cholesterol concentrations and lecithin-cholesterol acyltransferase activity in winter suggest that hibernating bears tightly controlled peripheral-cholesterol synthesis and/or release. Finally, greater plasma-antioxidant capacities prevented excessive lipid-specific oxidative damages in plasma and muscles of hibernating bears. Hence, the brown bear manages large lipid fluxes during hibernation, without developing adverse atherogenic effects that occur in humans and non-hibernators. |
format |
Text |
author |
Giroud, Sylvain Chery, Isabelle Arrivé, Mathilde Prost, Michel Zumsteg, Julie Heintz, Dimitri Evans, Alina L. Gauquelin-Koch, Guillemette Arnemo, Jon M. Swenson, Jon E. Lefai, Etienne Bertile, Fabrice Simon, Chantal Blanc, Stéphane |
author_facet |
Giroud, Sylvain Chery, Isabelle Arrivé, Mathilde Prost, Michel Zumsteg, Julie Heintz, Dimitri Evans, Alina L. Gauquelin-Koch, Guillemette Arnemo, Jon M. Swenson, Jon E. Lefai, Etienne Bertile, Fabrice Simon, Chantal Blanc, Stéphane |
author_sort |
Giroud, Sylvain |
title |
Hibernating brown bears are protected against atherogenic dyslipidemia |
title_short |
Hibernating brown bears are protected against atherogenic dyslipidemia |
title_full |
Hibernating brown bears are protected against atherogenic dyslipidemia |
title_fullStr |
Hibernating brown bears are protected against atherogenic dyslipidemia |
title_full_unstemmed |
Hibernating brown bears are protected against atherogenic dyslipidemia |
title_sort |
hibernating brown bears are protected against atherogenic dyslipidemia |
publisher |
Nature Publishing Group UK |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455566/ https://doi.org/10.1038/s41598-021-98085-7 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
Sci Rep |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455566/ http://dx.doi.org/10.1038/s41598-021-98085-7 |
op_rights |
© The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
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CC-BY |
op_doi |
https://doi.org/10.1038/s41598-021-98085-7 |
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Scientific Reports |
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11 |
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1 |
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