Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020
Lyssaviruses are the causative agents for rabies, a zoonotic and fatal disease. Bats are the ancestral reservoir host for lyssaviruses, and at least three different lyssaviruses have been found in bats from Germany. Across Europe, novel lyssaviruses were identified in bats recently and occasional sp...
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ftpubmed:oai:pubmedcentral.nih.gov:8402685 2023-05-15T17:13:46+02:00 Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020 Klein, Antonia Calvelage, Sten Schlottau, Kore Hoffmann, Bernd Eggerbauer, Elisa Müller, Thomas Freuling, Conrad M. 2021-08-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402685/ http://www.ncbi.nlm.nih.gov/pubmed/34452403 https://doi.org/10.3390/v13081538 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402685/ http://www.ncbi.nlm.nih.gov/pubmed/34452403 http://dx.doi.org/10.3390/v13081538 © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY Viruses Communication Text 2021 ftpubmed https://doi.org/10.3390/v13081538 2021-09-05T01:04:10Z Lyssaviruses are the causative agents for rabies, a zoonotic and fatal disease. Bats are the ancestral reservoir host for lyssaviruses, and at least three different lyssaviruses have been found in bats from Germany. Across Europe, novel lyssaviruses were identified in bats recently and occasional spillover infections in other mammals and human cases highlight their public health relevance. Here, we report the results from an enhanced passive bat rabies surveillance that encompasses samples without human contact that would not be tested under routine conditions. To this end, 1236 bat brain samples obtained between 2018 and 2020 were screened for lyssaviruses via several RT-qPCR assays. European bat lyssavirus type 1 (EBLV-1) was dominant, with 15 positives exclusively found in serotine bats (Eptesicus serotinus) from northern Germany. Additionally, when an archived set of bat samples that had tested negative for rabies by the FAT were screened in the process of assay validation, four samples tested EBLV-1 positive, including two detected in Pipistrellus pipistrellus. Subsequent phylogenetic analysis of 17 full genomes assigned all except one of these viruses to the A1 cluster of the EBLV-1a sub-lineage. Furthermore, we report here another Bokeloh bat lyssavirus (BBLV) infection in a Natterer’s bat (Myotis nattereri) found in Lower Saxony, the tenth reported case of this novel bat lyssavirus. Text Myotis nattereri Pipistrellus pipistrellus PubMed Central (PMC) Viruses 13 8 1538 |
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PubMed Central (PMC) |
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Communication |
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Communication Klein, Antonia Calvelage, Sten Schlottau, Kore Hoffmann, Bernd Eggerbauer, Elisa Müller, Thomas Freuling, Conrad M. Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020 |
topic_facet |
Communication |
description |
Lyssaviruses are the causative agents for rabies, a zoonotic and fatal disease. Bats are the ancestral reservoir host for lyssaviruses, and at least three different lyssaviruses have been found in bats from Germany. Across Europe, novel lyssaviruses were identified in bats recently and occasional spillover infections in other mammals and human cases highlight their public health relevance. Here, we report the results from an enhanced passive bat rabies surveillance that encompasses samples without human contact that would not be tested under routine conditions. To this end, 1236 bat brain samples obtained between 2018 and 2020 were screened for lyssaviruses via several RT-qPCR assays. European bat lyssavirus type 1 (EBLV-1) was dominant, with 15 positives exclusively found in serotine bats (Eptesicus serotinus) from northern Germany. Additionally, when an archived set of bat samples that had tested negative for rabies by the FAT were screened in the process of assay validation, four samples tested EBLV-1 positive, including two detected in Pipistrellus pipistrellus. Subsequent phylogenetic analysis of 17 full genomes assigned all except one of these viruses to the A1 cluster of the EBLV-1a sub-lineage. Furthermore, we report here another Bokeloh bat lyssavirus (BBLV) infection in a Natterer’s bat (Myotis nattereri) found in Lower Saxony, the tenth reported case of this novel bat lyssavirus. |
format |
Text |
author |
Klein, Antonia Calvelage, Sten Schlottau, Kore Hoffmann, Bernd Eggerbauer, Elisa Müller, Thomas Freuling, Conrad M. |
author_facet |
Klein, Antonia Calvelage, Sten Schlottau, Kore Hoffmann, Bernd Eggerbauer, Elisa Müller, Thomas Freuling, Conrad M. |
author_sort |
Klein, Antonia |
title |
Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020 |
title_short |
Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020 |
title_full |
Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020 |
title_fullStr |
Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020 |
title_full_unstemmed |
Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018–2020 |
title_sort |
retrospective enhanced bat lyssavirus surveillance in germany between 2018–2020 |
publisher |
MDPI |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402685/ http://www.ncbi.nlm.nih.gov/pubmed/34452403 https://doi.org/10.3390/v13081538 |
genre |
Myotis nattereri Pipistrellus pipistrellus |
genre_facet |
Myotis nattereri Pipistrellus pipistrellus |
op_source |
Viruses |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402685/ http://www.ncbi.nlm.nih.gov/pubmed/34452403 http://dx.doi.org/10.3390/v13081538 |
op_rights |
© 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/v13081538 |
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Viruses |
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13 |
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8 |
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1538 |
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1766070950513606656 |