Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot
The efficacy of intraperitoneal injection of an oil-based bivalent autogenous vaccine and the commercial vaccine AlphaJect 3000 (Pharmaq AS) to prevent atypical furunculosis and vibriosis in turbot was analyzed. The effect of both vaccines on health parameters and survival of fish after challenge wi...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402583/ http://www.ncbi.nlm.nih.gov/pubmed/34452031 https://doi.org/10.3390/vaccines9080906 |
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ftpubmed:oai:pubmedcentral.nih.gov:8402583 2023-05-15T18:41:01+02:00 Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot Torres-Corral, Yolanda Girons, Albert González-Barreiro, Oscar Seoane, Rafael Riaza, Ana Santos, Ysabel 2021-08-14 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402583/ http://www.ncbi.nlm.nih.gov/pubmed/34452031 https://doi.org/10.3390/vaccines9080906 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402583/ http://www.ncbi.nlm.nih.gov/pubmed/34452031 http://dx.doi.org/10.3390/vaccines9080906 © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY Vaccines (Basel) Article Text 2021 ftpubmed https://doi.org/10.3390/vaccines9080906 2021-09-05T01:03:52Z The efficacy of intraperitoneal injection of an oil-based bivalent autogenous vaccine and the commercial vaccine AlphaJect 3000 (Pharmaq AS) to prevent atypical furunculosis and vibriosis in turbot was analyzed. The effect of both vaccines on health parameters and survival of fish after challenge with V. anguillarum and A. salmonicida subsp. achromogenes was tested. The autogenous vaccine conferred high levels of protection and long-lasting immunity against both pathogens with a single dose. However, severe side effects were observed in turbot injected with this autovaccine and minor negative effects with the AlphaJect 3000 vaccine and the adjuvant Montanide or Eolane. All vaccinated fish showed remarkable antibody agglutination titers, higher than those of control fish, which were maintained 160 d after vaccination. In conclusion, the autogenous bivalent vaccine induces long-lasting protection against atypical furunculosis and vibriosis in turbot, after administration of a single dose, at the cost of high side effects in fish. Therefore, the development of new vaccines should focus on autovaccines and the use of liquid paraffin adjuvants that increase protection with reduced or no side effects. Text Turbot PubMed Central (PMC) Vaccines 9 8 906 |
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Article Torres-Corral, Yolanda Girons, Albert González-Barreiro, Oscar Seoane, Rafael Riaza, Ana Santos, Ysabel Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot |
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description |
The efficacy of intraperitoneal injection of an oil-based bivalent autogenous vaccine and the commercial vaccine AlphaJect 3000 (Pharmaq AS) to prevent atypical furunculosis and vibriosis in turbot was analyzed. The effect of both vaccines on health parameters and survival of fish after challenge with V. anguillarum and A. salmonicida subsp. achromogenes was tested. The autogenous vaccine conferred high levels of protection and long-lasting immunity against both pathogens with a single dose. However, severe side effects were observed in turbot injected with this autovaccine and minor negative effects with the AlphaJect 3000 vaccine and the adjuvant Montanide or Eolane. All vaccinated fish showed remarkable antibody agglutination titers, higher than those of control fish, which were maintained 160 d after vaccination. In conclusion, the autogenous bivalent vaccine induces long-lasting protection against atypical furunculosis and vibriosis in turbot, after administration of a single dose, at the cost of high side effects in fish. Therefore, the development of new vaccines should focus on autovaccines and the use of liquid paraffin adjuvants that increase protection with reduced or no side effects. |
format |
Text |
author |
Torres-Corral, Yolanda Girons, Albert González-Barreiro, Oscar Seoane, Rafael Riaza, Ana Santos, Ysabel |
author_facet |
Torres-Corral, Yolanda Girons, Albert González-Barreiro, Oscar Seoane, Rafael Riaza, Ana Santos, Ysabel |
author_sort |
Torres-Corral, Yolanda |
title |
Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot |
title_short |
Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot |
title_full |
Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot |
title_fullStr |
Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot |
title_full_unstemmed |
Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot |
title_sort |
effect of bivalent vaccines against vibrio anguillarum and aeromonas salmonicida subspecie achromogenes on health and survival of turbot |
publisher |
MDPI |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402583/ http://www.ncbi.nlm.nih.gov/pubmed/34452031 https://doi.org/10.3390/vaccines9080906 |
genre |
Turbot |
genre_facet |
Turbot |
op_source |
Vaccines (Basel) |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402583/ http://www.ncbi.nlm.nih.gov/pubmed/34452031 http://dx.doi.org/10.3390/vaccines9080906 |
op_rights |
© 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/vaccines9080906 |
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Vaccines |
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906 |
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