Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice
The intestinal flora is recognized as a significant contributor to the immune system. In this research, the protective effects of oyster peptides on immune regulation and intestinal microbiota were investigated in mice treated with cyclophosphamide. The results showed that oyster peptides restored t...
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ftpubmed:oai:pubmedcentral.nih.gov:8401037 2023-05-15T15:58:38+02:00 Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice Xiang, Xing-Wei Zheng, Hui-Zhen Wang, Rui Chen, Hui Xiao, Jin-Xing Zheng, Bin Liu, Shu-Lai Ding, Yu-Ting 2021-08-11 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401037/ http://www.ncbi.nlm.nih.gov/pubmed/34436295 https://doi.org/10.3390/md19080456 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401037/ http://www.ncbi.nlm.nih.gov/pubmed/34436295 http://dx.doi.org/10.3390/md19080456 © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY Mar Drugs Article Text 2021 ftpubmed https://doi.org/10.3390/md19080456 2021-09-05T00:59:35Z The intestinal flora is recognized as a significant contributor to the immune system. In this research, the protective effects of oyster peptides on immune regulation and intestinal microbiota were investigated in mice treated with cyclophosphamide. The results showed that oyster peptides restored the indexes of thymus, spleen and liver, stimulated cytokines secretion and promoted the relative mRNA levels of Th1/Th2 cytokines (IL-2, IFN-γ, IL-4 and IL-10). The mRNA levels of Occludin, Claudin-1, ZO-1, and Mucin-2 were up-regulated, and the NF-κB signaling pathway was also activated after oyster peptides administration. Furthermore, oyster peptides treatment reduced the proportion of Firmicutes/Bacteroidetes, increased the relative abundance of Alistipes, Lactobacillus, Rikenell and the content of short-chain fatty acids, and reversed the composition of intestinal microflora similar to that of normal mice. In conclusion, oyster peptides effectively ameliorated cyclophosphamide-induced intestinal damage and modified gut microbiota structure in mice, and might be utilized as a beneficial ingredient in functional foods for immune regulation. Text Crassostrea gigas PubMed Central (PMC) Marine Drugs 19 8 456 |
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Article Xiang, Xing-Wei Zheng, Hui-Zhen Wang, Rui Chen, Hui Xiao, Jin-Xing Zheng, Bin Liu, Shu-Lai Ding, Yu-Ting Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice |
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Article |
description |
The intestinal flora is recognized as a significant contributor to the immune system. In this research, the protective effects of oyster peptides on immune regulation and intestinal microbiota were investigated in mice treated with cyclophosphamide. The results showed that oyster peptides restored the indexes of thymus, spleen and liver, stimulated cytokines secretion and promoted the relative mRNA levels of Th1/Th2 cytokines (IL-2, IFN-γ, IL-4 and IL-10). The mRNA levels of Occludin, Claudin-1, ZO-1, and Mucin-2 were up-regulated, and the NF-κB signaling pathway was also activated after oyster peptides administration. Furthermore, oyster peptides treatment reduced the proportion of Firmicutes/Bacteroidetes, increased the relative abundance of Alistipes, Lactobacillus, Rikenell and the content of short-chain fatty acids, and reversed the composition of intestinal microflora similar to that of normal mice. In conclusion, oyster peptides effectively ameliorated cyclophosphamide-induced intestinal damage and modified gut microbiota structure in mice, and might be utilized as a beneficial ingredient in functional foods for immune regulation. |
format |
Text |
author |
Xiang, Xing-Wei Zheng, Hui-Zhen Wang, Rui Chen, Hui Xiao, Jin-Xing Zheng, Bin Liu, Shu-Lai Ding, Yu-Ting |
author_facet |
Xiang, Xing-Wei Zheng, Hui-Zhen Wang, Rui Chen, Hui Xiao, Jin-Xing Zheng, Bin Liu, Shu-Lai Ding, Yu-Ting |
author_sort |
Xiang, Xing-Wei |
title |
Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice |
title_short |
Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice |
title_full |
Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice |
title_fullStr |
Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice |
title_full_unstemmed |
Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice |
title_sort |
ameliorative effects of peptides derived from oyster (crassostrea gigas) on immunomodulatory function and gut microbiota structure in cyclophosphamide-treated mice |
publisher |
MDPI |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401037/ http://www.ncbi.nlm.nih.gov/pubmed/34436295 https://doi.org/10.3390/md19080456 |
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Crassostrea gigas |
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Crassostrea gigas |
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Mar Drugs |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401037/ http://www.ncbi.nlm.nih.gov/pubmed/34436295 http://dx.doi.org/10.3390/md19080456 |
op_rights |
© 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/md19080456 |
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Marine Drugs |
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