Lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats
By generating raw genetic material and diverse biological functions, gene duplication represents a major evolutionary mechanism that is of fundamental importance in ecological adaptation. The lineage-specific duplication events of bitter taste receptor genes (Tas2rs) have been identified in a number...
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ftpubmed:oai:pubmedcentral.nih.gov:8381267 2023-05-15T13:33:11+02:00 Lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats Jiao, Hengwu Wang, Yi Zhang, Libiao Jiang, Peihua Zhao, Huabin 2018-11-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381267/ http://www.ncbi.nlm.nih.gov/pubmed/30230081 https://doi.org/10.1111/mec.14873 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381267/ http://www.ncbi.nlm.nih.gov/pubmed/30230081 http://dx.doi.org/10.1111/mec.14873 Mol Ecol Article Text 2018 ftpubmed https://doi.org/10.1111/mec.14873 2021-08-29T00:39:47Z By generating raw genetic material and diverse biological functions, gene duplication represents a major evolutionary mechanism that is of fundamental importance in ecological adaptation. The lineage-specific duplication events of bitter taste receptor genes (Tas2rs) have been identified in a number of vertebrates, but functional evolution of new Tas2r copies after duplication remains largely unknown. Here we present the largest data set of bat Tas2rs to date, identified from existing genome sequences of 15 bat species and newly sequenced from 17 bat species, and demonstrate lineage-specific duplications of Tas2r16, Tas2r18, and Tas2r41 that only occurred in Myotis bats. Myotis bats are highly speciose and represent the only mammalian genus that is naturally distributed on every continent except Antarctica. The occupation of such diverse habitats might have driven the Tas2r gene expansion. New copies of Tas2rs in Myotis bats have shown molecular adaptation and functional divergence. For example, three copies of Tas2r16 in Myotis davidii showed differential sensitivities to arbutin and salicin that may occur in their insect prey, as suggested by cell-based functional assays. We hypothesize that functional differences among Tas2r copies in Myotis bats would increase their survival rate through preventing the ingestion of an elevated number of bitter-tasting dietary toxins from their insect prey, which may have facilitated their adaptation to diverse habitats. Our study demonstrates functional changes of new Tas2r copies after lineage-specific duplications in Myotis bats and highlights the potential role of taste perception in exploiting new environments. Text Antarc* Antarctica PubMed Central (PMC) Molecular Ecology 27 22 4475 4488 |
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Article Jiao, Hengwu Wang, Yi Zhang, Libiao Jiang, Peihua Zhao, Huabin Lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats |
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Article |
description |
By generating raw genetic material and diverse biological functions, gene duplication represents a major evolutionary mechanism that is of fundamental importance in ecological adaptation. The lineage-specific duplication events of bitter taste receptor genes (Tas2rs) have been identified in a number of vertebrates, but functional evolution of new Tas2r copies after duplication remains largely unknown. Here we present the largest data set of bat Tas2rs to date, identified from existing genome sequences of 15 bat species and newly sequenced from 17 bat species, and demonstrate lineage-specific duplications of Tas2r16, Tas2r18, and Tas2r41 that only occurred in Myotis bats. Myotis bats are highly speciose and represent the only mammalian genus that is naturally distributed on every continent except Antarctica. The occupation of such diverse habitats might have driven the Tas2r gene expansion. New copies of Tas2rs in Myotis bats have shown molecular adaptation and functional divergence. For example, three copies of Tas2r16 in Myotis davidii showed differential sensitivities to arbutin and salicin that may occur in their insect prey, as suggested by cell-based functional assays. We hypothesize that functional differences among Tas2r copies in Myotis bats would increase their survival rate through preventing the ingestion of an elevated number of bitter-tasting dietary toxins from their insect prey, which may have facilitated their adaptation to diverse habitats. Our study demonstrates functional changes of new Tas2r copies after lineage-specific duplications in Myotis bats and highlights the potential role of taste perception in exploiting new environments. |
format |
Text |
author |
Jiao, Hengwu Wang, Yi Zhang, Libiao Jiang, Peihua Zhao, Huabin |
author_facet |
Jiao, Hengwu Wang, Yi Zhang, Libiao Jiang, Peihua Zhao, Huabin |
author_sort |
Jiao, Hengwu |
title |
Lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats |
title_short |
Lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats |
title_full |
Lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats |
title_fullStr |
Lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats |
title_full_unstemmed |
Lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats |
title_sort |
lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381267/ http://www.ncbi.nlm.nih.gov/pubmed/30230081 https://doi.org/10.1111/mec.14873 |
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Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Mol Ecol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381267/ http://www.ncbi.nlm.nih.gov/pubmed/30230081 http://dx.doi.org/10.1111/mec.14873 |
op_doi |
https://doi.org/10.1111/mec.14873 |
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Molecular Ecology |
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27 |
container_issue |
22 |
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4475 |
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4488 |
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1766039320598151168 |